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I am wondering if these GLP-1 drugs will lose the appetite suppression effect after an extended period of time

The clinical data suggest otherwise. For most people, there is a dose dependent body weight homeostasis. At this point we have a few years of data for semaglutide and maybe a couple for tirzepatide. Those that can afford to stay on it, don't regain the weight typically. There is some evidence that cycling on and off of various ones may cause a loss of efficacy.

I mean, that is sort of how most drugs work, right? And with the GLP folks it would appear to be the same as the long term users take higher and higher doses over time or else start combining multiple GLP drugs into a stack. Or both.

That's how some drugs work. The people doing the stacking are typically just being impatient. They want to lose all the weight NOW and then come off, which is a really terrible idea.

I also feel like there's some benefit to tapering and doing a "diet break" every so often to avoid metabolic adaptation. This is works for folks in an extended deficit without GLP1 RAs. I don't see any reason why it wouldn't work for those on one.

And before any of you fuckers call me fat and geriatric, I was 9% this morning and well... I am pretty old, so I guess that applies.
 
How much injectible discipline did you shoot up today?

you keep talking shit to every new person that comes in, color me surprised that you fat fucks act the victim when you finally get called out

Oh and I am also so surprised to hear there's more glp1 fatties in here then actual bodybuilders, so genuinely shocked

Its almost like it takes zero effort to get fat
 
How much injectible discipline did you shoot up today?

you keep talking shit to every new person that comes in, color me surprised that you fat fucks act the victim when you finally get called out

Oh and I am also so surprised to hear there's more glp1 fatties in here then actual bodybuilders, so genuinely shocked

Its almost like it takes zero effort to get fat
Buddy your physique would be laughed at in a Bikini forum, not sure you wanna go down that rabbit hole.

But please If you do, post picture so we can laugh a bit or shut the fuck up.

Your contribution to this forum has been zero, actually if we wanna be brutally honest it is negative as the only thing you are able to type is a big pile of delusional shit.

I know it hurts to be seen like the retarded kid at school but you know what they say... If it walks like a retard, talks like a retard, must be a retard.

Now Korey I believe QSC has still pepchat available where you can tell ppl stupid advices and try to look like you know anything about steroids and how to cycle or homebrew, go back playing there, that's a good playground for you kid, you will feel at home in that special class room.
 
How much injectible discipline did you shoot up today?

you keep talking shit to every new person that comes in, color me surprised that you fat fucks act the victim when you finally get called out

Oh and I am also so surprised to hear there's more glp1 fatties in here then actual bodybuilders, so genuinely shocked

Its almost like it takes zero effort to get fat
You're so right for being envious of fat people taking glp to get serious, immediate results, particularly after you've spent years and tens of thousands on lifestyle with absolutely nothing to show for it and to still look like a scrawny, androgynous hipster. I'd be salty, too, if I was you.
 
I'm not reading the diary of yet another 40 year old with basic self discipline issues. The only thing you have in common with bodybuilders is your drug dealer



It's honestly funny just how many fat fucks got triggered by the truth

You two are obese.
One thing we know for sure, you are a damn masochist, popping up here just to be shitted on by everyone it does show a great level of self inflicted punishment.

Do you get a stiffy for getting insulted? You do right? Ahahah gotcha!

How many time did you already cum in your dirty sock? Does your mummy knows what you doing in the basement?
 
Just wanna point out that your account didn’t exist 6 months ago.
I figured since the handle is called 'secondlives' it's probably someone that was previously banned (most likely for arguing with someone that was injecting "liquid self discipline" ). If I may venture out on a limb, he's also bitter that he didn't receive enough backing during this alleged incident. He's now back on a one man crusade to rid the forum of 'fatties'.
Good luck to him. As anyone would know, it's hard to get rid of fat.
 
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Worst part of this game. Why can’t I just eat in a surplus in perpetuity and not gain fat? Maybe I can with SLU-PP-332…
i dont know anything about slu-pp-332.. I do not think it is hard to maintain 12-14 % bf once you get there.. In my personal experince going from say 26% to12% was hard AF, it took a lot of focus hardwork, dedication and drugs. Currently trying to pack on some mass so we shall see how it goes tryiong to stay fairly lean at the same time.
D
 
i dont know anything about slu-pp-332.. I do not think it is hard to maintain 12-14 % bf once you get there.. In my personal experince going from say 26% to12% was hard AF, it took a lot of focus hardwork, dedication and drugs.
D
Agreed as I can maintain where I am now (approximately 12.5%) pretty effortlessly assuming the other aspects of my routine remain unchanged.

I have never been sub 10% however, which is a goal I have on the horizon for sure. If for no other reason, I want to be able to prove to myself that I can do it.
 
i dont know anything about slu-pp-332.. I do not think it is hard to maintain 12-14 % bf once you get there.. In my personal experince going from say 26% to12% was hard AF, it took a lot of focus hardwork, dedication and drugs. Currently trying to pack on some mass so we shall see how it goes tryiong to stay fairly lean at the same time.
D
Agreed on maintaining 12 to 14 being pretty easy. I just mean, why can't I eat whatever I want and not get fat? lol. Just want my cake and to eat it too is all.

In my experience, growing and staying lean is helped quite a bit by higher GH doses. SLU-PP-332 is supposed to ameliorate fat gain during a caloric surplus; it's an aerobic exercise mimetic. Giving it a test right now.
 
Agreed as I can maintain where I am now (approximately 12.5%) pretty effortlessly assuming the other aspects of my routine remain unchanged.

I have never been sub 10% however, which is a goal I have on the horizon for sure. If for no other reason, I want to be able to prove to myself that I can do it.
That's my ultimate goal as it also supports my cycling goals....getting lean and lowering bodyweight.

Should be the leanest I ever have been in several weeks if I stick to plan, but probably won't because of holidays lol.
 
Agreed on maintaining 12 to 14 being pretty easy. I just mean, why can't I eat whatever I want and not get fat? lol. Just want my cake and to eat it too is all.

In my experience, growing and staying lean is helped quite a bit by higher GH doses. SLU-PP-332 is supposed to ameliorate fat gain during a caloric surplus; it's an aerobic exercise mimetic. Giving it a test right now.
Eventually you would get sick of eating pure shit everyday. When we were gone on our cruise earlier this year the novelty of shoveling junk was cool for about the first 3-4 days. After that, I just felt gross.

By the time we got home I was SOOO relived to be back on my routine.
 
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