Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[LightWeight89]

Yes

Injectable anadrol

 

[Qingdao Sigma Chemicals]

Injectable anadrol

We have oral one.

 

[tuffie]

What will the adjusted price for Test oils be moving forward Nov 23. Pre-orders are over for the 60$, can orders be taken for test oil but with the adjusted price?

 

[Here2Learn]

I'll stick to the non-controversial general rules for minimizing degradation. Keep in mind some peptides are fine at room temp for months, others degrade practically by the hour, at room temp. Peptides are a category as broad as "food".

1. Darker the better.

2. Colder the better (however, freeze thaw cycles are damaging and must be avoided. Even one will "cost" something). .

3. A cryofreezer that gets to at least -80c is ideal, as good as it gets.

Don't even think about using a "frost free" freezer, which most residential units are, They cycle cold and warm temps to keep ice from building up. Some chest freezers are manual defrost.

If you can swing it, a $800-$1,000 mini-cryofreezer, the size of portable cooler, is a good investment for long term peptide storage, bringing degradation as close to zero as possible for many years. The gold standard. They were $6,000+ until recently..

Personally I keep them in the lowest part of the refrigerator, towards the back, in a lightproof box. At least until my cryofreezer arrives.

I’m not able to purchase a separate freezer and using my normal one. I have mine packed in insulated black box wrapped with freezer pouches in giant ziplock bags. Figure the ice packs will help negate the freeze/thaw cycle plus the insulated boxes I got from Temu. My issue now is I have completely filled my insulated boxes and need to order another once since I’ve been buying way more than I expected. lol

 

[HB_22]

View attachment 304525Injecting QSC Test e 2x per week 0.8ml Monday/Thursday and my levels are worse than when i was natty. Bloods done on the thursday before injecting and have been on his test for over 5 weeks now, can someone help.

Tell us how and where you inject.
And 0.8ml means nothing as you could inject 0.8ml of gear with just 0mg/ml, or 0.8ml of 500mg/ml. Dosages are in mg, volumes are in ml.

 

[LeroyJenkins]

Tell us how and where you inject.
And 0.8ml means nothing as you could inject 0.8ml of gear with just 0mg/ml, or 0.8ml of 500mg/ml. Dosages are in mg, volumes are in ml.

Qsc's test e is 250mg/ml

 

[Rawbie]

Monday we will start accepting primo preorders.

@Trenbolonetax I TOLD YOU!! Speak it into existence lol

 

[Ghoul]

@Ghoul

QSC has had two BPC's recently.
10mg @ 99.878%
20mg @ 96.944%

You're talking about the 20mg being impure right?

Any guesses what the missing 2.8% stuff is?

TLDR: purer the better and safer, including doing what you can to reduce further degradation once in storage and after reconstitution.

This isn't like testing water, where all contaminants in the water are identified and measured, like arsenic, lead, etc.

It's a measure of how much of the peptide is the correct amino acid sequence that makes up that peptide.

The "other stuff" are amino acid sequences that are incorrect, from defective manufacturing adding or deleting amino acids. or damaged from degradation (light, heat, etc).

Here you can see "demon amino" sneaking into the peptide, waiting to lodge somewhere in your brain, starting a slow chain reaction that will melt your eyeballs a decade from now...



(only half joking here, as many degenerative brain diseases are linked to defective peptides/proteins)


Specifically identifying impurities requires "peptide mapping" which I've never seen performed on a UGL peptide. Pharma of course has to do this. identifying every impurity in their product, including pulling some off the shelf and identifying the degradation impurities that develop once the drug is in the hands of a customer.


Sometimes they're harmless, merely reducing potency of the drug, other times they're not harmless, essentially creating new, unidentified drugs. The FDA wants to see any new "impurity" greater than .10% specifically identified and the pharma company explain why it's not a concern. Over .50% is generally unacceptable and must be eliminated or the contaminant undergo comprehensive testing to demonstrate it's not harmful.

Some peptides already create such a strong immune reponse they're on the borderline of becoming a risk to health if it gets any worse. Those are on a list and given extra scrutiny for the presence of new contaminants with each new batch.

Whether a peptide is produced by a recombinant or synthetic process, impurities may result from the insertion, deletion, or modification of amino acid sequences or residues. These impurities can be controlled in the synthetic process. At low levels, consistent with batch-to-batch variability, they generally pose minimal pharmacological or toxicological risks that would affect safety or effectiveness. However, in some circumstances, peptide-related impurities may create the potential for differences in immunogenicity or may otherwise affect the safety or effectiveness of a peptide drug product. Because of these concerns about the potential for immunogenicity for glucagon, liraglutide, nesiritide, teriparatide, and teduglutide, the type of...

*this is from a 2021 FDA report and not a comprehensive list of peptides requiring special surveillance due to immunogenicity concerns.

 

[UncleBuns]

Buy from the current GH promo now or what till Monday for the "Biggest Sale Every".... Fuck.

 

[Trenbolonetax]

Buy from the current GH promo now or what till Monday for the "Biggest Sale Every".... Fuck.

I have a solution! Porque no los dos?

 

[UncleBuns]

I have a solution! Porque no los dos?

Just bargain hunting. I don't need it right now. It's just kind of a fun game. If I put in an order now and Monday there's even a slightly better deal. I'll be pissed but only for like 5 minutes and then I won't really care at all. Just having some fun.

 

[UncleBuns]

I have a solution! Porque no los dos?

Split second decision. I'm going to hold out and see what Monday reveals.

 

[SpaceGhost]

Split second decision. I'm going to hold out and see what Monday reveals.

Same. I have a feeling it'll be peptides and glps, but maybe we'll be pleasantly surprised.

 

[Ghoul]

@Ghoul

QSC has had two BPC's recently.
10mg @ 99.878%
20mg @ 96.944%

You're talking about the 20mg being impure right?

Any guesses what the missing 2.8% stuff is?

Just to give you a more complete understanding, here's one of the very few comprehensive impurity analysis of "street peptides", since there isn't much incentive for anyone to spend the money necessary to evaluate peptides as comprehensively as pharma:

(TLDR: To minimize risk buy the purest you can, store under the best conditions you can, reconstitute properly, filter):

Moreover, our analysis demonstrated the presence of toxic class one elemental impurities (inorganic As an Pb) next to the high variations in content and high amounts of API-related impurities in these samples and thus clearly illustrates the health risks users/patients face when resorting to falsified peptide drugs. Both Pb and inorganic As are known (genotoxic) elemental impurities which in acute intoxications or prolonged exposure may lead to adverse health effects on multiple vital organs and in some cases also result in lethal outcomes. The presence of concentrations up to ten times the known toxicity limits for parenteral drugs raises questions about the quality of chemicals used and the purification process.

Furthermore, the presence of certain related impurities such as dea-midations, insertion and deletion of amino acids and the formation of aggregates may lead to loss of functionality and even toxic effects. Most of the detected related impurities in these preparations (oxidations, deamidations, dimerformations,...) could also be induced during storage or handling under certain conditions.

Hence, demonstrating that next to the analysis of the API and synthesis artefacts also degradation products (specifically for peptides which were not subjected to preclinical or clinical trials) may not be neglected in the risk evaluation of falsified peptide drugs.

Taken together, the results of this study clearly demonstrate and confirm the suspicions that these products do not meet the required safety regulations regarding the purity of the API and chemical impurities in these preparations.

Consequently, the (sustained) administration of these preparations may result in adverse acute and chronic health effects.

https://www.sciensano.be/sites/default/files/janvier_et_al._-_2018_-_impurity_profiling_of_the_most_frequently_encounte.pdf

 

[Letits now]

I got my intl order in just over a week, which is pretty impressive this time of year. But I hope the packaging does get improved as I got a tiny paper-thin box that was crushed and it's very lucky that nothing was broken.

The vials were inside a actually kinda clever 'hiding in plain sight' fake packaging similar to a typical OTC med box, but nothing to really contain well if there was a spill They were semi-protected by plastic as shown. The cute labels are my own. I do hope the pressed haters on here enjoy my cute little piggies.

There was absolutely no labeling/numbering of any kind anywhere. I deliberately made a small odd-numbered order figuring that might be the case. I would like if there could be some kind of label on, even just a number, if I were to make a larger more complicated order. And consider better quality box + a ziploc bag & bubble wrap at least, post office is seriously rougher on boxes by the month these days. I've gotten more and more boxes actually delivered in busted wide open condition, luckily I live where there is no porch pirate issue yet.

Buy from the current GH promo now or what till Monday for the "Biggest Sale Every".... Fuck.

Just buy both! Everyone in here is loaded.

 

[Here2Learn]

I need a Reta sale as I thought I had more than I did so missed the last greatest ever sale. Was more Tirz and not Reta ‍

 

[synthesis30]

Black November: Promo n°10 Raws & Peptides: last day

Peptides:
- Tirzepatide 10x50mg $265/kit
- Tirzepatide 10x10mg $55/kit
- BPC157 10x20mg $65/kit
- Foxo4 Dri 10x10mg $300/kit

Raw powders:
Sustanon 100g $90
Sustanon 500g $300
Sustanon 1000g $500

Oxandrolone 50g $200
Oxandrolone 100g $375
Oxandrolone 500g $1500
Oxandrolone 1000g $2850

Boldenone U 1000g $500

NB:
- Shipping is charged.
- The promo is international.
- Bac water, Bac water with AA, PBS can be added to the order.
- You can combine both raws and peptides in the same parcels and pay only one shipping fee
- You can't add items not part of this promo to your order, it must be a seperate one.

Peptides Lab tests:
- Janoshik Analytical
- Janoshik Analytical
- Janoshik Analytical
- Janoshik Analytical

Deadline: 23 November 2024 (USA time)

How to order?
‌‎
sigma@sigmachemical.com.cn
Whatsapp: +86 16503300980
‎
Ordering form:
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List of items you want:
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Shipping address (including city, state and zip code):
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Is FOXO4-DRI available at the international warehouse now? I would like to order some Reta as well.

 

[Qingdao Sigma Chemicals]

Is FOXO4-DRI available at the international warehouse now? I would like to order some Reta as well.

yes available

 

[UncleBuns]

Just buy both! Everyone in here is loaded.

Nah. I'm holding out. If the mega sale is unimpressive then no biggie. I'll just hold out for the next one.