Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[readalot]

Thanks. Also, what sort of answer, specifically, are you looking for RE: thought progression?

Just the reasoning behind each dose increase or something more?

Just curious how you got to that final dose per day.

See for example...

The effect of four weeks of supraphysiological growth hormone administration on the insulin-like growth factor axis in women and men. GH-2000 Study Group - PubMed

Measurements of serum insulin-like growth factor I (IGF-I) and related markers are routinely used in the diagnosis and treatment of GH deficiency and excess. The validity of these markers for assessment of exogenous GH exposure in healthy adults is, however, unknown. We therefore conducted a...

pubmed.ncbi.nlm.nih.gov

Did you measure IGF-1 at each titration point along the way?

0.1 IU/kg/day enough to send many way up into the +4 SD land. See Fig 2 and discussion. Most males saturated at 0.1 IU/kg/day.

Appreciate your data set.

 

[FastBun]

Lmao has anyone read this article from WSJ. Could you imagine the fuckery of a response Tracy would give. View attachment 316511

This might be the part where… Eli lily goes hard on them… making qsc a big target for fda. Ghoul prob has better insight on this…

 

[ovrdooze]

View attachment 316515

free tibet is the perfect example of how the west takes these issues seriously, both about the superficial knowledge of the situation and how it's ditched after it gets old - if they'd invade Taiwan noone would care after 5-10 years. remember the uyghurs? nah, that's so 2010

 

[FastBun]

wasn’t Stan just saying he needed more money? May have been in jest, but I don’t get the impression domestic sellers are making that much. Maybe a couple hundred k a year at most take home

Bruv… you really believe that?? Im not going to post what I’m positive he makes a Month because this is a highly looked thread I’m sure by LE…i Would pm but doesn’t let me…0

 

[Trailmixed]

This might be the part where… Eli lily goes hard on them… making qsc a big target for fda. Ghoul prob has better insight on this…

Kind of pissed me off that some nurse soccer mom just outrightly gave the news agency her source of Reta.

 

[FastBun]

Kind of pissed me off that some nurse soccer mom just outrightly gave the news agency her source of Reta.

When you are that big bound to happen…

 

[Middus]

Kind of pissed me off that some nurse soccer mom just outrightly gave the news agency her source of Reta.

The article is quite Old... from back in the day when Look and Mizhao chem were sending cold emails..

 

[Trailmixed]

The article is Very Old... from back in the day when Look and Mizhao chem were sending cold emails..

Dated 9 May 2024

 

[FastBun]

wasn’t Stan just saying he needed more money? May have been in jest, but I don’t get the impression domestic sellers are making that much. Maybe a couple hundred k a year at most take home

San Diego Resident Charged for Maintaining a Steroid Distribution Center in Spring Valley

The U.S. Attorney’s Office unsealed a complaint today charging San Diego resident Edgar Lopez Feliciano with maintaining a steroid distribution center in Spring Valley. As detailed in the complaint, Feliciano’s network is allegedly involved in the creation and distribution of significant...

www.justice.gov

 

[readalot]

You guys should also remember that my IGF-1 levels are NOT the ones you'd expect from 90 iu:
I'm aware exogenous HGH dosage conversion to IGF-1 is very variable/vague; however, these are IGF-1 levels that are easily representative of sub 20 iu per day dosing, so it's not as if I'm experiencing the IGF-1 elevation usually expected from 90 iu a day. This is the WHOLE POINT of the discussion.

Should have added this quote in my prior post. My understanding is that there may be almost no difference between measured IGF-1 at 20 IU/day vs 90 IU/day. See study posted and the dot plots of 0.1 vs 0.2 IU/kg/day (Fig 2). Asymptotic dose response.

 

[glpfun]

Bruv… you really believe that?? Im not going to post what I’m positive he makes a Month because this is a highly looked thread I’m sure by LE…i Would pm but doesn’t let me…0

A kilo of test c raws is around 300 and if you sell for 35 a 10 ml vial at 250mg/ml. Let’s say 10% loss so we have 900 g of usable raw material and each vial is 2.5 g so we get about 360 vials. Each is 35 dollars and which yields 12600 minus the initial raws cost were at 12300. All that work and selling 360 vials for a measly 12k? How does that make someone rich? That’s ignoring all the other operating costs which is non trivial and the risk of selling a controlled substance. I appreciate that people do this, but clearly there are better ways to make money if that is the intent.

 

[Mma67]

Lmao has anyone read this article from WSJ. Could you imagine the fuckery of a response Tracy would give. View attachment 316511

Fat ass couch potato Karen trying to ruin QSC. Bitch was hit by a golf ball 20 years ago and is still trying to be a victim any way possible. Pro tip: stop buying so much food and redirect your money to the pharma grade stuff. Leave the underground markets alone.

 

[Middus]

Dated 9 May 2024

More like october 2023

 

[Trailmixed]

More like october 2023

Nice

 

[Middus]

Nice

There is a recent (research) article that researchers placed an order with some chinese vendors

 

[nullandvoid]

Fat ass couch potato Karen trying to ruin QSC. Bitch was hit by a golf ball 20 years ago and is still trying to be a victim any way possible. Pro tip: stop buying so much food and redirect your money to the pharma grade stuff. Leave the underground markets alone.

Probably the only balls she's had in her face in the same amount of time.

 

[FastBun]

A kilo of test c raws is around 300 and if you sell for 35 a 10 ml vial at 250mg/ml. Let’s say 10% loss so we have 900 g of usable raw material and each vial is 2.5 g so we get about 360 vials. Each is 35 dollars and which yields 12600 minus the initial raws cost were at 12300. All that work and selling 360 vials for a measly 12k? How does that make someone rich? That’s ignoring all the other operating costs which is non trivial and the risk of selling a controlled substance. I appreciate that people do this, but clearly there are better ways to make money if that is the intent.

You are doing 1 compound… they have over 20+ products…mind you… they go through more than 1 kilo a month of raw of a compound… muscle candy states this…

 

[Wrangel7]

Titration was mainly determined (sorry to disappoint) by the rate of PO (progressive overload) + side effects and continuous/non-lab health markers, such as HRV, RHR, BG and the like and also occasional lab blood testing, including HbA1c, organ health, etc… basic/general comprehensive panel to make sure there wasn’t any severe risk to health.

However, IGF-1 testing was rarer due to cost-cutting because I thought my subjective assessment of exogenous HGH effects based on progression, sides and general health markers was sufficient.

Regarding the point where most males saturated around 0.1 iu/kg, and after that point, the change was simply more side effects (which doesn't fit my side effect changes/profile completely), with minimal additional IGF-1 elevation, and the PO I observed after this proposed saturation point, I think we should consider:

1. other growth mechanisms from exogenous HGH dose increases were responsible for additional PO
1.1. non-IGF-1 mediated growth pathways cause significant PO/anabolism
1.2. alternative signalling cascades, direct receptor activation, enhanced satellite cell activation, improved nutrition partitioning, etc..

2. local IGF-1 production (in muscle tissue) was stimulated by increased HGH doses and this may have a saturation point higher than serum IGF-1 / local increases supported growth despite plateaus in systemic IGF-1

3. some other factor which coincided with increased HGH dosing was responsible for increased PO and this is a coincidence / additional HGH was largely wasted (even beyond the expected diminishing returns)

Conclusion: more funding needed (LOL) to repeat (but not to the same extreme extent) up-titration with exogenous HGH with more IGF-1 monitoring, as well as what @Ghoul said about immunogenicity testing.

Just curious how you got to that final dose per day.

See for example...

The effect of four weeks of supraphysiological growth hormone administration on the insulin-like growth factor axis in women and men. GH-2000 Study Group - PubMed

Measurements of serum insulin-like growth factor I (IGF-I) and related markers are routinely used in the diagnosis and treatment of GH deficiency and excess. The validity of these markers for assessment of exogenous GH exposure in healthy adults is, however, unknown. We therefore conducted a...

pubmed.ncbi.nlm.nih.gov

Did you measure IGF-1 at each titration point along the way?

0.1 IU/kg/day enough to send many way up into the +4 SD land. See Fig 2 and discussion. Most males saturated at 0.1 IU/kg/day.

Appreciate your data set.

Should have added this quote in my prior post. My understanding is that there may be almost no difference between measured IGF-1 at 20 IU/day vs 90 IU/day. See study posted and the dot plots of 0.1 vs 0.2 IU/kg/day (Fig 2). Asymptotic dose response.

 

[readalot]

Titration was mainly determined (sorry to disappoint) by the rate of PO (progressive overload) + side effects and continuous/non-lab health markers, such as HRV, RHR, BG and the like and also occasional lab blood testing, including HbA1c, organ health, etc… basic/general comprehensive panel to make sure there wasn’t any severe risk to health.

However, IGF-1 testing was rarer due to cost-cutting because I thought my subjective assessment of exogenous HGH effects based on progression, sides and general health markers was sufficient.

Regarding the point where most males saturated around 0.1 iu/kg, and after that point, the change was simply more side effects (which doesn't fit my side effect changes/profile completely), with minimal additional IGF-1 elevation, and the PO I observed after this proposed saturation point, I think we should consider:

1. other growth mechanisms from exogenous HGH dose increases were responsible for additional PO
1.1. non-IGF-1 mediated growth pathways cause significant PO/anabolism
1.2. alternative signalling cascades, direct receptor activation, enhanced satellite cell activation, improved nutrition partitioning, etc..

2. local IGF-1 production (in muscle tissue) was stimulated by increased HGH doses and this may have a saturation point higher than serum IGF-1 / local increases supported growth despite plateaus in systemic IGF-1

3. some other factor which coincided with increased HGH dosing was responsible for increased PO and this is a coincidence / additional HGH was largely wasted (even beyond the expected diminishing returns)

Conclusion: more funding needed (LOL) to repeat (but not to the same extreme extent) up-titration with exogenous HGH with more IGF-1 monitoring, as well as what @Ghoul said about immunogenicity testing.

Thanks for sharing your thoughts and feedback.

 

[baxter0312]

You are doing 1 compound… they have over 20+ products…mind you… they go through more than 1 kilo a month of raw of a compound… muscle candy states this…

Also test is what you might call a “loss leader”. Priced lower to entice buyers who will add more stuff to the order that would have higher profit margins