Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[Ghoul]

Just got my first kits of Tesamorelin. If anyone has any particular tips or anecdotal data, would love to hear their experiences.

Been using it daily for 8 months. 2mg/d in the morning.

I reconstitute with 3ml Hospira.

Switched from filtering the entire vial to per dose filtration, which reduced the site reactions 90%.

I keep the contents of the whole reconstituted vial in a 3ml syringe with filter and needle attached. Still backfilling insulin pins from that setup. Realizing the entire barrel of the insulin syringe is exposed to air even with the plunger in makes me even less concerned about the 5 seconds the plunger is removed to backfill.

No sides whatsoever.

IGF saw a ~100 point boost.

Significant stomach flattening as will as all the other expected GH benefits to hair, nails etc, but took a few months to notice.

Tesa is a marathon, not a sprint. Max benefits usually take 6-12 months to develop. It's intended for lifetime use.

 

[Clover 0080]

 

[Swolemates365]

R

Post in thread 'Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic'

Feb 18, 2025

Of course. They do.

AFAIC the primary topics that should be front and center every day for all source threads are issues directly related to source products/services accountability, testing results, scam warnings, etc.

This should be even more of a priority when a source is missing in action where warnings to customers of source status can prevent future harm, and reports of (unfulfilled) outstanding orders can document past/ongoing harm.

I understand and appreciate the inherently social and off-topic nature of communities such as MESO. Given this, I want to encourage focus on...

• readalot

• 

Warning!

"This should be even more of a priority when a source is missing in action where warnings to customers of source status can prevent future harm, and reports of (unfulfilled) outstanding orders can document past/ongoing harm."

But does this source need a warning since they’re not taking any correspondence, order or payments?

 

[MaryQContrary]

Been using it daily for 8 months. 2mg/d in the morning.

I reconstitute with 3ml Hospira.

Switched from filtering the entire vial to per dose filtration, which reduced the site reactions 90%.

I keep the contents of the whole reconstituted vial in a 3ml syringe with filter and needle attached. Still backfilling insulin pins from that setup. Realizing the entire barrel of the insulin syringe is exposed to air even with the plunger in makes me even less concerned about the 5 seconds the plunger is removed to backfill.

No sides whatsoever.

IGF saw a ~100 point boost.

Significant stomach flattening as will as all the other expected GH benefits to hair, nails etc, but took a few months to notice.

Tesa is a marathon, not a sprint. Max benefits usually take 6-12 months to develop. It's intended for lifetime use.

This is great info. I had a reaction about a year and a half ago when I tried Tesa and have wanted to give it a go, again. I’ll google the process you’re referencing and see if I can get a better grasp on backfilling. I need to lean out and lose about 10 lbs before I start a cycle of it.
Thanks for your insight.

Also, thanks @readalot for linking that video re: filtering. I’ve just been going at it unfiltered and you guys have me a bit more educated.

Appreciate it.

 

[Ghoul]

This is great info. I had a reaction about a year and a half ago when I tried Tesa and have wanted to give it a go, again. I’ll google the process you’re referencing and see if I can get a better grasp on backfilling. I need to lean out and lose about 10 lbs before I start a cycle of it.
Thanks for your insight.

Also, thanks @readalot for linking that video re: filtering. I’ve just been going at it unfiltered and you guys have me a bit more educated.

Appreciate it.

Here's a peptide filtering vid just posted in another thread,

I was having this exact thought earlier today, and I came across this video on YouTube:


View: https://youtu.be/o7EUN3FGzPs?si=TZQqiZquolleKD03


Can anyone comment on the quality of this filtering process? Is this a safe tutorial to reference?

To back fill instead of filling a vial, pull the plunger out of an insulin syringe, put the rubber plunger tip into the plunger cap just removed from the syringe, and lay that down to keep the tip from touching non sterile surfaces, fill the insulin syringe with the filtered syringe needle at an angle inside the insulin syringe barrel. cap the filtered needle, put the plunger into the insulin syringe just barely. Flip needle side up, tap until the air bubble rises to the top, and push the plunger in enough to expel the air, Ince you have it down should take less than 10 seconds. Practice with water first.

 

[MaryQContrary]

Here's a peptide filtering vid just posted in another thread,



To back fill instead of filling a vial, pull the plunger out of an insulin syringe, put the rubber plunger tip into the plunger cap just removed from the syringe, and lay that down to keep the tip from touching non sterile surfaces, fill the insulin syringe with the filtered syringe needle at an angle inside the insulin syringe barrel. cap the filtered needle, put the plunger into the insulin syringe just barely. Flip needle side up, tap until the air bubble rises to the top, and push the plunger in enough to expel the air, Ince you have it down should take less than 10 seconds. Practice with water first.

View attachment 317272View attachment 317273

Thank you!!!

 

[aljowa]

Here's a peptide filtering vid just posted in another thread,



To back fill instead of filling a vial, pull the plunger out of an insulin syringe, put the rubber plunger tip into the plunger cap just removed from the syringe, and lay that down to keep the tip from touching non sterile surfaces, fill the insulin syringe with the filtered syringe needle at an angle inside the insulin syringe barrel. cap the filtered needle, put the plunger into the insulin syringe just barely. Flip needle side up, tap until the air bubble rises to the top, and push the plunger in enough to expel the air, Ince you have it down should take less than 10 seconds. Practice with water first.

View attachment 317272

Oh, wow, excellent. Thank you.

Out of curiosity, what would be the practical application of doing this method of a syringe back-fill instead of just filtering into a vial?

 

[Ghoul]

Oh, wow, excellent. Thank you.

Out of curiosity, what would be the practical application of doing this method of a syringe back-fill instead of just filtering into a vial?

Aggregates form when the peptide is in liquid form during manufacturing or after reconstitution.

After filtration, the peptide solution will be free of large aggregates. However, depending on the specific peptide, PH of the solution, concentration, and other factors, aggregates can reform. (ie 1 point of PH difference can speed up aggregate formation 10x in HGH).

So filtering as close to administration is ideal, since there's no "incubation" time for new aggregates to form.

Tesa is compound known to induce site reactions even in pharma formulations. After filtering into a new vial there was no site reaction during the first dose vs the painful unfiltered Tesa.

However, by the 3rd, 4th, and 5th daily doses pain gradually intensified, suggesting aggregates reformed.

By filtering each dose just before use, those injection site reactions are virtually eliminated, which suggests a lower level of immunogenicity, to maintain maximum efficacy.

Not every peptide is as prone to rapid aggregation so filtering into a vial may be fine. But we usually don't even know whether the PH of a peptide solution is correct. I just per dose filter them all now. I could do it blindfolded.

That said, I'm not wagging my finger at anyone saying you must do this. I've decided this is a low effort process I'm willing to use because of what my research into aggregation has shown me the benefits likely are.

Here's a little about "incubation" in a wonky paper about GLP aggregation I was reading earlier today.

https://pubs.acs.org/doi/10.1021/acs.bioconjchem.4c00484

 

[SkeetSlambone]

I just got out of prison.. .. the deffo dont hand you an ipad as you walk throught he door.. not where I was anyway. They hand you a pair of boots and you had better put those mother fuckers on. .... you can tell a person comfort level in prison by what they sleep in... fully clothed boots on=new or scared.. sleep in your boxers= get me if want I don't give a fuck....

Ahh the iPads and tablets. For what it's worth, all that stems from the FCC putting limits on what Detainees could be charged for phone calls. This is one of the few "big government" interventions I agree with. It's gross what they were doing due to having literally a captive audience.

Once that happened, suddenly the GTL's, Talton, Keefe, etc...all talked their customers into deploying tablets since the FCC isn't controlling Video Chat, music, movies, email...etc.

 

[BamaCrazy]

Anyone ever purchased a peptide mix for sleep that has the below? I am trying to figure out dosage for tonight.

Midnight Blend 261.25mg (20ml)​

Product Contains: Histidine 75mg, GABA 75mg, Taurine 75mg, Theonine 35mg, Melatonin 1.25mg

 

[Proud_papa_pump]

Anyone ever purchased a peptide mix for sleep that has the below? I am trying to figure out dosage for tonight.

Midnight Blend 261.25mg (20ml)​

Product Contains: Histidine 75mg, GABA 75mg, Taurine 75mg, Theonine 35mg, Melatonin 1.25mg

That looks interesting. I like the name too.

 

[aljowa]

Aggregates form when the peptide is in liquid form during manufacturing or after reconstitution.

After filtration, the peptide solution will be free of large aggregates. However, depending on the specific peptide, PH of the solution, concentration, and other factors, aggregates can reform. (ie 1 point of PH difference can speed up aggregate formation 10x in HGH).

So filtering as close to administration is ideal, since there's no "incubation" time for new aggregates to form.

Tesa is compound known to induce site reactions even in pharma formulations. After filtering into a new vial there was no site reaction during the first dose vs the painful unfiltered Tesa.

However, by the 3rd, 4th, and 5th daily doses pain gradually intensified, suggesting aggregates reformed.

By filtering each dose just before use, those injection site reactions are virtually eliminated, which suggests a lower level of immunogenicity, to maintain maximum efficacy.

Not every peptide is as prone to rapid aggregation so filtering into a vial may be fine. But we usually don't even know whether the PH of a peptide solution is correct. I just per dose filter them all now. I could do it blindfolded.

That said, I'm not wagging my finger at anyone saying you must do this. I've decided this is a low effort process I'm willing to use because of what my research into aggregation has shown me the benefits likely are.

Here's a little about "incubation" in a wonky paper about GLP aggregation I was reading earlier today.

View attachment 317276View attachment 317277

https://pubs.acs.org/doi/10.1021/acs.bioconjchem.4c00484

Interesting. I'm finally going to commit to filtering my Tirzepatide, and I'm planning on starting GH in the next 2-3 months (after I'm more confident in my knowledge base on GH). I want to maximize efficacy from the beginning with the GH, so this information is invaluable and greatly appreciated.

 

[BamaCrazy]

That looks interesting. I like the name too.

I’m assuming 1mL is recommended dosage. 1.25mg of Melatonin is not much. Oh well, it’s going in me. Lol

 

[glpfun]

@chmuse what steroids are you gonna do first

 

[chmuse]

@chmuse what steroids are you gonna do first

I figured I'd take the oyster approach and just try all of them for a week and see what I like

If you're serious I'm currently debating combining ostarine with survo when it comes in, milos mentioned it and I'm intrigued.

But I also like my liver, it's taken a beating already.

 

[SkeetSlambone]

I figured I'd take the oyster approach and just try all of them for a week and see what I like

If you're serious I'm currently debating combining ostarine with survo when it comes in, milos mentioned it and I'm intrigued.

There is a Pharma Co testing a GLP1 combined with Ostarine.

 

[chmuse]

There is a Pharma Co testing a GLP1 combined with Ostarine.

Yep that's why I'm interested.

 

[Proud_papa_pump]

I figured I'd take the oyster approach and just try all of them for a week and see what I like

If you're serious I'm currently debating combining ostarine with survo when it comes in, milos mentioned it and I'm intrigued.

But I also like my liver, it's taken a beating already.

I was not impressed with my 9 week cycle of Osta. I didn’t have a Test base, so that was part of it, but I don’t feel it is strong enough to really benefit the user.

 

[glpfun]

I figured I'd take the oyster approach and just try all of them for a week and see what I like

If you're serious I'm currently debating combining ostarine with survo when it comes in, milos mentioned it and I'm intrigued.

But I also like my liver, it's taken a beating already.

We already have an oyster here, check this thread out Rektest - Death is available log

 

[chmuse]

I was not impressed with my 9 week cycle of Osta. I didn’t have a Test base, so that was part of it, but I don’t feel it is strong enough to really benefit the user.

I just don't want to lose too much muscle while I lose weight. What's the point of getting sober and skinny if I can't even ride my bike or go hiking or swimming anymore.

Enobosarm I was also eyeballing. One of my meds fucks with bone density and I'm at risk of hormonal breast cancer. Idk. Early stages. I'm only 4 months in on sema I've got time to research more and decide.

I'm not JUST here to crack jokes and pretend I'm in love with Tracy. I AM actually reading stuff in an effort to learn.