Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[Sampei]

This is one for HBA1c

View attachment 317533


I've seen a NASH one in the past, but I'm too lazy to do another search

Vision loss: GLP-1 drugs like Ozempic linked to 3 eye conditions

A new review reports that nine people taking semaglutide and tirzepatide — the active ingredient in GLP-1 medications — experienced vision issues, including three potentially blinding eye conditions.

www.medicalnewstoday.com

Following this news that sudden drop in BG with glp1 drugs can create this issues, reta become even more interesting as it doesn't allow your body to go hypoglicemic. That's why ppl find it doesn't reduce your BG much.... For what I have understood it's not really it doesn't reduce it much.. it is more a balancer of BG. So compares to tirz and sema that will just reduce it as much as they can so unless you are counterbalancing it with loads of carb or induced insulin resistance (HGH) you can go hypo.

Reta instead as soon as your body goes below a threshold it starts releasing glucose from the liver and raise the BG.

Many ppl that were suffering from hypoglicemia fixed their BG using reta

 

[Swolemates365]

Welp, reality has set in! Tracy is gone! Good luck everyone

 

[Proud_papa_pump]

Welp, reality has set in! Tracy is gone! Good luck everyone

Bye

 

[Proud_papa_pump]

She ain't t charging me anything she my homegirl she sending me some from some place called sky peptides??? But she said that place ZYH or whatever was cool but that pbg was like shopping in a thrift store that smells like pee..... hahaha She is a close friend so we don't charge each othe for stuff.. although dhe never really needs anything from me..

Skye is very reputable, though very expensive. PGB is just a very convenient vendor who sells with a slight markup compared to China vendors. Their thorough Jano testing makes it worthwhile for most.

 

[Dirthand]

Skye is very reputable, though very expensive. PGB is just a very convenient vendor who sells with a slight markup compared to China vendors. Their thorough Jano testing makes it worthwhile for most.

Yeah I know that place cost a bunch... I guess she is somehow intertwined... I told my friend the other day when I bought some peptides from PGB that it's like she gets to wear gucci and I shop at walmart(which is no problem luv wally word) she come back and said PGB was like shopping at thrift store that smell like pee not walmart..lol obviously itd personal.. I didn't ask, I just thought it was funny!!! I see no problem with either place.. welll except price but its not always about the cheapest.. I'm blessed to be able to get some Ferrari parts for free.. imma slap em on my pinto, and pimp it!!!
Peace
D

 

[Dirthand]

Vision loss: GLP-1 drugs like Ozempic linked to 3 eye conditions

A new review reports that nine people taking semaglutide and tirzepatide — the active ingredient in GLP-1 medications — experienced vision issues, including three potentially blinding eye conditions.

www.medicalnewstoday.com

Following this news that sudden drop in BG with glp1 drugs can create this issues, reta become even more interesting as it doesn't allow your body to go hypoglicemic. That's why ppl find it doesn't reduce your BG much.... For what I have understood it's not really it doesn't reduce it much.. it is more a balancer of BG. So compares to tirz and sema that will just reduce it as much as they can so unless you are counterbalancing it with loads of carb or induced insulin resistance (HGH) you can go hypo.

Reta instead as soon as your body goes below a threshold it starts releasing glucose from the liver and raise the BG.

Many ppl that were suffering from hypoglicemia fixed their BG using reta

So potentially useful if you may be dabbling with insulin???

 

[Sampei]

So potentially useful if you may be dabbling with insulin???

Kinda even so many of the effect and mechanism of glucagon are still not really understood or maybe not shown in any studies as it's still being approved at least with reta.

 

[Ghoul]

l

Kinda even so many of the effect and mechanism of glucagon are still not really understood or maybe not shown in any studies as it's still being approved at least with reta.

Sema 7.2mg and CagriSema trials both ended up being failures(hitting Novo's stock price) , despite early promising results, so worth keeping in mind that Reta may yet turn up with a few surprises of its own, especially with so little data regarding glucagon.

Didn't you and others develop full body skin sensitivity for some unknown reason?

I haven't seen that mentioned in the Reta trial, so maybe it's a special feature of our perfectly made, safety focused Chinese UGL produced copies.

 

[BamaCrazy]

l

Sema 7.2mg and CagriSema trials both ended up being failures(hitting Novo's stock price) , despite early promising results, so worth keeping in mind that Reta may yet turn up with a few surprises of its own, especially with so little data regarding glucagon.

Didn't you and others develop full body skin sensitivity for some unknown reason?

I haven't seen that mentioned in the Reta trial, so maybe it's a special feature of our perfectly made, safety focused Chinese UGL produced copies.

I got skin sensitivity on Mounjaro and compounded Tirz. But it was worse on Reta. I’ve also seen Ozempic users report the same on Reddit.

 

[Ghoul]

I got skin sensitivity on Mounjaro and compounded Tirz. But it was worse on Reta. I’ve also seen Ozempic users report the same on Reddit.

It's not reported in any of the clinical data for the pharma versions of either of those compounds, including the 3 and 4 year studies, which strongly suggests a systemic immunogenic reaction to me.

Not to be confused with a limited site reaction, also an immune response, but much more limited.

Filtering to remove aggregates could help stop that from happening,

Expanding Bedside Filtration—A Powerful Tool to Protect Patients From Protein Aggregates

Protein immunogenicity is intensively researched by academics, biopharmaceutical companies, and authorities as it can compromise the safety and efficacy of a biopharmaceutical drug. So far, the exact protein aggregate properties inducing immune responses are not known. Possible protein-related...

colab.ws

 

[Sampei]

l

Sema 7.2mg and CagriSema trials both ended up being failures(hitting Novo's stock price) , despite early promising results, so worth keeping in mind that Reta may yet turn up with a few surprises of its own, especially with so little data regarding glucagon.

Didn't you and others develop full body skin sensitivity for some unknown reason?

I haven't seen that mentioned in the Reta trial, so maybe it's a special feature of our perfectly made, safety focused Chinese UGL produced copies.

Skin sensitivity is a thing of all the glp1 Tirzepatide and Semaglutide have it reported too.

Retatrutide has 7% of ppl participating in the trials reporting it.

Is mostly transient for all the glp1, except for few cases.

So no your assumption that is UGL thing is not correct..plenty of reports online from ppl injecting ozempic and mounjaro that have it

 

[Sampei]

I got skin sensitivity on Mounjaro and compounded Tirz. But it was worse on Reta. I’ve also seen Ozempic users report the same on Reddit.

Correct, it's something that can affect any glp-1 users

 

[ddauria88]

Welp, reality has set in! Tracy is gone! Good luck everyone

You make a comment or two per day that is super attention seeking.. it’s like you want us to coddle you and assure you everything is going to be okay. Guess what man, everything will be okay… life is great. If Tracy comes back that surely makes everyone’s life in here better - if he doesn’t… nothing changes.

 

[Sampei]

It's not reported in any of the clinical data for the pharma versions of either of those compounds, including the 3 and 4 year studies, which strongly suggests a systemic immunogenic reaction to me.

Not to be confused with a limited site reaction, also an immune response, but much more limited.

Filtering to remove aggregates could help stop that from happening,

Expanding Bedside Filtration—A Powerful Tool to Protect Patients From Protein Aggregates

Protein immunogenicity is intensively researched by academics, biopharmaceutical companies, and authorities as it can compromise the safety and efficacy of a biopharmaceutical drug. So far, the exact protein aggregate properties inducing immune responses are not known. Possible protein-related...

colab.ws

Skin-related side effects
Another side effect reported in the clinical trials was skin sensitivity to touch, pain, pressure and heat. These events were reported in approximately 7% of the participants receiving retatrutide, compared to 1% in the placebo group.

Importantly, these skin-related side effects were generally mild to moderate in severity and did not result in the discontinuation of retatrutide or placebo.

 

[Ghoul]

Skin sensitivity is a thing of all the glp1 Tirzepatide and Semaglutide have it reported too.

Retatrutide has 7% of ppl participating in the trials reporting it.

Is mostly transient for all the glp1, except for few cases.

So no your assumption that is UGL thing is not correct..plenty of reports online from ppl injecting ozempic and mounjaro that have it

Full body skin sensitivity is not reported in any clinical data for pharma Tirz or Sema, including studies with over 10,000 participants carefully monitored for 4 years, and they list 50+ reported side effects with as few as 4 people experiencing them.

Maybe the anecdotal reports to you're referring to are psychosomatic, picking it up from all the UGL user reports, or perhaps they leave their pens in warm temps for extended periods forming aggregates, but in controlled conditions with pharma grade meds, it has not been observed.

 

[Swolemates365]

You make a comment or two per day that is super attention seeking.. it’s like you want us to coddle you and assure you everything is going to be okay. Guess what man, everything will be okay… life is great. If Tracy comes back that surely makes everyone’s life in here better - if he doesn’t… nothing changes.

That exactly what I want attention and coddled. It couldn’t actually just be shit posting like much everyone else. Or just be bored off my ass at work and just want to throw some random shit out there. But I appreciate you quoting me and replying and giving me the attention I was seeking.

 

[Ghoul]

Skin-related side effects
Another side effect reported in the clinical trials was skin sensitivity to touch, pain, pressure and heat. These events were reported in approximately 7% of the participants receiving retatrutide, compared to 1% in the placebo group.

Importantly, these skin-related side effects were generally mild to moderate in severity and did not result in the discontinuation of retatrutide or placebo.

I said it wasn't in the Sema and Tirz clinical data, which is extensive, and mentioned I hadn't seen it in the limited Reta data that's been released.

Without identifying the underlying cause, if it's related to glucagon, you have to wonder what else this novel agonist might be doing that hasn't been identified yet.

Then again, it could just be an issue with
the formulation. I've seen FDA documents where pharma and FDA agreed to tweak a rHGH formulation (or storage conditions) before approving it for sale to reduce aggregate formation, in order to lessen the chance of reactions like this.

 

[Sampei]

Full body skin sensitivity is not reported in any clinical data for pharma Tirz or Sema, including studies with over 10,000 participants carefully monitored for 4 years, and they list 50+ reported side effects with as few as 4 people experiencing them.

Maybe the anecdotal reports to you're referring to are psychosomatic, picking it up from all the UGL user reports, or perhaps they leave their pens in warm temps for extended periods forming aggregates, but in controlled conditions with pharma grade meds, it has not been observed.

Allodynia has been reported on other glp1 drugs and doctors are reporting that their patients are starting to develop it on ozempic and Tirzepatide.

There are plenty of ppl on mounjaro and ozempic reporting it too. Unless we don't believe ppl first hand experience or we believe that everyone is on grey GLP1 even when they clearly state they are not. I would stop beating the aggregates war drum incessantly because there are plenty of ppl that filter their GLP1 and still get the allodynia from it.

If you assume that everything is because of ONE single reason you create a narrative that is impossible to agree with and it makes no sense as well plus it makes it a clown joke instead of a good harm reduction practice.

Not everything can be fixed with bed filtration or filtering of peptides, because sometime there is nothing to fix, it's just a side effect and ignoring it or making it seems like they are all mad and it's all because of poor UGL quality makes the whole debate ridiculous.

 

[Middus]

So potentially useful if you may be dabbling with insulin???

The risk is there, but consider that it's majorly for Men, over the age of 55, Obese with sleep apnea and type 2 diabetes, and worst in those previously at risk for NAION..
The peak is around 22 months. I'm pushing 18 months so I'll let you know in 4 months .

Actually There's another study that says well there's sort of a risk that isn't generalizable to the public, and worry may be excessive, plus the benefits of GLP1s outweigh said risks (I paraphrase)

 

[Sampei]

The risk is there, but consider that it's majorly for Men, over the age of 55, Obese with sleep apnea and type 2 diabetes, and worst in those previously at risk for NAION..
The peak is around 22 months. I'm pushing 18 months so I'll let you know in 4 months .

Actually There's another study that says well there's sort of a risk that isn't generalizable to the public, and worry may be excessive, plus the benefits of GLP1s outweigh said risks (I paraphrase)

Well yeah if one is obese or diabetic and can improve is quality of life consistently and the risk is minuscule it's well worth it. That side effect however could interest more ppl like BBs using it for glucose control where the benefit of using it could be not really worth it compared of risking blindness xD

Again it's all theoretical as you well said at the moment there are no certainty and it's not clear if there is a direct correlation.