Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[piggy_nui]

I use metformin once daily at night. 1000mg extended release and haven’t had any side effects that I know of. There are days I don’t take it. Mainly forgetting to take it but most of the time I do.

I’m taking 500 mg a day, usually after lunch. I’m also taking 2.5 Tirzepatide, now I’m somewhat worried about going blind…

 

[Juiced_lizard]

I’m taking 500 mg a day, usually after lunch. I’m also taking 2.5 Tirzepatide, now I’m somewhat worried about going blind…

Going blind because of hypoglycemia?

 

[Ghoul]

I’m taking 500 mg a day, usually after lunch. I’m also taking 2.5 Tirzepatide, now I’m somewhat worried about going blind…

I personally experienced effects of hypoglycemia with Sema (blurred vision lasting 30-60 seconds)until I dropped the metformin.

Never happened again at any dose
of Sema or Tirz since.

 

[Juiced_lizard]

I personally experienced hypoglycemia with Sema until I dropped the metformin.

What were your sugars running? You stayed low all day?

 

[piggy_nui]

Going blind because of hypoglycemia?

Yes? Although last time I checked my fasting glucose was around 85. Not bad.

 

[Juiced_lizard]

Yes? Although last time I checked my fasting glucose was around 85. Not bad.

85 isn’t hypoglycemic. I average mid 80’s myself. I check mine 3-6 times a day. My fasting morning glucose is about 86-90 though most mornings depending on how long I’ve slept for.

Glucometers are very cheap and lot of insurances give them away. My insurance gave me a meter and all the lancets/testing strips. Either way they are very cheap on Amazon.

 

[Ateam2023]

BPC likely is bullshit. I would question why big pharma' hasn't touched it with a 10-foot pole. I don't join people's conversations and be a little shit. It appears to be innocuous, hence my indifference.

I responded to another person saying more nuance is required, you joined and said it's the "goat" depending on the field, and I responded that I'm talking about benifits that transcend weight loss. Then, you made the claim that "Switch to Fatty Liver and Reta beats the others..". I asked if that claim was based off anecdote or evidence, and was genuinely curious if I was wrong and there was studies regarding such. You then linked a study that discussed HbA1c -- not NAFLD, and implied that Retatrutide was better at HbA1c reduction. I then pointed out that that was incorrect, based on the limited data your article provided.

Just for in case you forgot. Now please explain at what point I said or implied that your statement was unsafe. It's simply illogical and unsupported. It's also bad principle for the forum as a whole, in my opinion.

Sure thing.

Your other claim of "For stuff like type 2 diabetes, Sema remains slightly ahead" is also unfounded. I'll let chatGPT explain.

i've had Fantastic success with bpc157, ymmv,

 

[Sampei]

You could use metformin for glucose control but then there are other side effects correct?

As a bodybuilder you mean?

Glp1 have a plethora of benefit that Metformin don't have. Decrease of systemic inflammation, liver defatting, cardiovascular protection, a lot stronger glucose control.

Metformin impair resistance training as well and it's not that strong in glucose control compared to glp1 and it's missing all those other benefits a glp1 have.

Of course there are the side effect of GLP1 to take into account, so it's always a balance that need to be Found

 

[Letits now]

She ain't t charging me anything she my homegirl she sending me some from some place called sky peptides??? But she said that place ZYH or whatever was cool but that pbg was like shopping in a thrift store that smells like pee..... hahaha She is a close friend so we don't charge each othe for stuff.. although dhe never really needs anything from me..

What the f dude?! My friends don’t give me free shit, let alone top quality stuff like that.
I need to meet this girl.

 

[Ghoul]

What were your sugars running? You stayed low all day?

Pre meal it was 90-95 on average.

Full disclosure, this was also prior
to understanding the importance of pharmacokinetics (PK) and injecting a 2.4mg dose with just .20ml. Had I used the same .75ml as Novo does at that dose, the Sema would've been absorbed much more gradually, and perhaps avoided that problem.

It always happened within 20-30 minutes of injecting, so PK could've played a role, Scary shit though, since it doesn't take long for hypoglycemia induced nerve damage to occur in the eyes.

 

[Ateam2023]

Welp, reality has set in! Tracy is gone! Good luck everyone

 

[piggy_nui]

Pre meal it was 90-95 on average.

Full disclosure, this was also prior
to understanding the importance of pharmacokinetics (PK) and injecting a 2.4mg dose with just .20ml. Had I used the same .75ml as Novo does at that dose, the Sema would've been absorbed much more gradually, and perhaps avoided that problem.

It always happened within 20-30 minutes of injecting, so PK could've played a role, Scary shit though, since it doesn't take long for hypoglycemia induced nerve damage to occur in the eyes.

Since you know all… how much bac do I need to use for 2.5 of tirz? Thanks in advance!

 

[Ghoul]

Since you know all… how much bac do I need to use for 2.5 of tirz?

I certainly don't "know all" lol, but for all doses of Tirz up to 15mg it's .5ml.

When you expect to use multiple dose amounts from the same vial, dilute with enough for the lowest dose to be .5ml, since over dilution isn't really going to cause any problems, but excessively concentrated certainly can, for all peptides. Not just affecting. PK but aggregates are far more likely to form in highly concentrated solutions. Also, highly concentrate peptides injected sub-q are more likely to induce immunogenicity, since they can be more easily transported to lymph nodes, where the immune system "learns" how to effectively remove the peptide the next time it appears, leading to the more serious, long term type of immunity that slowly builds up and steadily reduces efficacy over months or years.

 

[piggy_nui]

I certainly don't "know all" lol, but for all doses of Tirz up to 15mg it's .5ml.

When you expect to use multiple dose amounts from the same vial, dilute with enough for the lowest dose to be .5ml, since over dilution isn't really going to cause any problems, but excessively concentrated certainly can, for all peptides. Not just affecting. PK, but aggregates are far more likely to form in highly concentrated solutions.

Ugh… was doing 0.2 ml… because cheap me was trying to get the highest amount of product in the least amount of water…

Do you have any indication for HgH, does that work the same way? Sharing is caring!

 

[Sampei]

What the f dude?! My friends don’t give me free shit, let alone top quality stuff like that.
I need to meet this girl.

Stand down, you hobo

 

[thecmorgan]

Didn't you and others develop full body skin sensitivity for some unknown reason?

It’s funny you mentioned skin sensitivity. I’ve been taking a high dose of Sema, and I just started experiencing that occasionally on my back and arms (if that’s the same thing you’re referring to). It’s the only effect/side effect I’ve noticed so far. It kind of feels like goosebumps or a sunburn, but without the pain.
Sema still, it hasn’t helped with appetite control, but now with this tingle sensation I know there has to be something in those vials besides baby laxative.

 

[Sampei]

Ugh… was doing 0.2 ml… because cheap me was trying to get the highest amount of product in the least amount of water…

Do you have any indication for HgH, does that work the same way? Sharing is caring!

10IU 0.5ml if I remember correctly is the minimum recommended dilution

 

[Ghoul]

Ugh… was doing 0.2 ml… because cheap me was trying to get the highest amount of product in the least amount of water…

Do you have any indication for HgH, does that work the same way? Sharing is caring!

Exactly the same principles apply to HGH.

Using the highest concentration of somatropin in a commercial formula it comes out to .05ml per IU. So 10iu would be .5ml. Keep in mind though, this is with numerous excipients UGL doesn't contain to control aggregates. I would just shoot for .5ml at any dose below 10iu, It'll keep your reconstituted peptide in better condition for longer than a more concentrated vial.

Aggregates form over time, the "incubation" period, and especially if you're filtering a vial once (vs per dose aka "bedside filtration"), a higher dilution rate buys more time.

 

[piggy_nui]

Exactly the same principles apply to HGH.

Using the highest concentration of somatropin in a commercial formula it comes out to .05ml per IU. So 10iu would be .5ml. Keep in mind though, this is with numerous excipients UGL doesn't contain to control aggregates. I would just shoot for .5ml at any dose below 10iu, It'll keep your reconstituted peptide in better condition for longer than a more concentrated vial.

Aggregates form over time, the "incubation" period, and especially if you're filtering a vial once (vs per dose aka "bedside filtration"), a higher dilution rate buys more time.

Everyday I learn something new. That’s the beauty of life. Thanks for the info!!!!

 

[BamaCrazy]

It’s funny you mentioned skin sensitivity. I’ve been taking a high dose of Sema, and I just started experiencing that occasionally on my back and arms (if that’s the same thing you’re referring to). It’s the only effect/side effect I’ve noticed so far. It kind of feels like goosebumps or a sunburn, but without the pain.
Sema still, it hasn’t helped with appetite control, but now with this tingle sensation I know there has to be something in those vials besides baby laxative.

Yea. It doesn’t have to be full body sensitivity. I’d sometimes have it just on my legs, sometimes on my arms and legs, and sometimes pretty much everywhere. It’s mostly subsided now after over 12+ months of GLP use.