As promised an update/review on the QSC tesofensine:
I bought a bunch from QSC before the testing controversy started. Decided to start at about 10mg a day based on rat studies which found ED50 in rats of about 2mg/kg. LD50 values are in the hundreds of grams/kg, so spare me the suicidal discussion. Also many reviewers in the past haven’t felt anything even at the normally high 2-5mg range, so I wanted to have no doubt whether it was working or not. Ramped my dose up to 25mg a day and I’m feeling some appetite reduction, not nearly quite like what the studies have indicated however. And nowhere near quite as pronounced as when I started semaglutide last fall. (Been off sema for 6 weeks now). The antidepressant effects of the tesofensine seem even more pronounced, as expected from a dopamine retake inhibitor. Heart rate and BP are essentially unchanged. I do feel jittery however— I feel like a wired teenager all day long. It was hard to focus on my job at times. Workouts have been great though, good energy. Seems like it fires you up much like the old DMAA did. I’m glad I bought it, but I’m not sure I’d buy it again. For a hundred dollars I have a 10 year supply. Another thought of mine, is it just doesn’t feel like this product has a half life anywhere near the supposed 220 hours. In rats it was measured at 2-3 hours.
Now what about the negative Jano tests? Well it turns out and as alluded by a previous poster there are several tesofensine analogs out there one of which is possibly what the Qsc stuff actually is. The testofensine-D5 analog is one of the more researched analogues, but has very limited research. It is also possible the the product is brasofensine or even NS-2359, both similar compounds in the phenyltropane family. Phenyltropanes are sometimes not particularly stable, although again research again is limited. The best known phenyltropane is cocaine. Interestingly tesofensine is more potent at dopamine reuptake inhibition than cocaine. The actual high from Cocaine is the result of some other mechanism, and the exact pharmacological mechanism remains uncertain. The tesofensine has not made me feel high but has given me a very happy yet wired disposition.
My question to Mr. Jano is, can you detect these other analogs/compounds with either gas or liquid chromatography? A lot of the evidence so far seems to imply it’s a related compound, but who knows. I had a definite response from it. If it’s not tesofensine I don’t blame QSC, they’re just getting it from a supplier, they can’t test every last thing. After all this is not US Pharma. people. And possibly it’s quite hard to test for the product itself. Overall I have had great luck with many QSC products.
I welcome thoughts and comments. Let’s keep the personal attacks out though. Thanks.
I bought a bunch from QSC before the testing controversy started. Decided to start at about 10mg a day based on rat studies which found ED50 in rats of about 2mg/kg. LD50 values are in the hundreds of grams/kg, so spare me the suicidal discussion. Also many reviewers in the past haven’t felt anything even at the normally high 2-5mg range, so I wanted to have no doubt whether it was working or not. Ramped my dose up to 25mg a day and I’m feeling some appetite reduction, not nearly quite like what the studies have indicated however. And nowhere near quite as pronounced as when I started semaglutide last fall. (Been off sema for 6 weeks now). The antidepressant effects of the tesofensine seem even more pronounced, as expected from a dopamine retake inhibitor. Heart rate and BP are essentially unchanged. I do feel jittery however— I feel like a wired teenager all day long. It was hard to focus on my job at times. Workouts have been great though, good energy. Seems like it fires you up much like the old DMAA did. I’m glad I bought it, but I’m not sure I’d buy it again. For a hundred dollars I have a 10 year supply. Another thought of mine, is it just doesn’t feel like this product has a half life anywhere near the supposed 220 hours. In rats it was measured at 2-3 hours.
Now what about the negative Jano tests? Well it turns out and as alluded by a previous poster there are several tesofensine analogs out there one of which is possibly what the Qsc stuff actually is. The testofensine-D5 analog is one of the more researched analogues, but has very limited research. It is also possible the the product is brasofensine or even NS-2359, both similar compounds in the phenyltropane family. Phenyltropanes are sometimes not particularly stable, although again research again is limited. The best known phenyltropane is cocaine. Interestingly tesofensine is more potent at dopamine reuptake inhibition than cocaine. The actual high from Cocaine is the result of some other mechanism, and the exact pharmacological mechanism remains uncertain. The tesofensine has not made me feel high but has given me a very happy yet wired disposition.
My question to Mr. Jano is, can you detect these other analogs/compounds with either gas or liquid chromatography? A lot of the evidence so far seems to imply it’s a related compound, but who knows. I had a definite response from it. If it’s not tesofensine I don’t blame QSC, they’re just getting it from a supplier, they can’t test every last thing. After all this is not US Pharma. people. And possibly it’s quite hard to test for the product itself. Overall I have had great luck with many QSC products.
I welcome thoughts and comments. Let’s keep the personal attacks out though. Thanks.
