Frigidshadow1998
New Member
Hi,
i Am so confused about this one thing, regarding idiopathic gynecomastia, I read a study saying that these men have high expression for estrogen receptors which explains how they can get gyno even with normal estrogen levels.
the Thing that is confusing me is that I read in one study “Pensler et al. [10] examined the expression of estrogen (ER) and progesterone (PR) receptors in breast tissue samples in patients with AG and with Klinefelter syn- drome. The authors found out that none of the patients with AG demonstrated positive expression of ER or PR contrary to those with Klinefelter syndrome. Lee et al. [11] examined the tissue receptor levels in breast tissue re- moved from 7 boys (aged 16–17 years) with AG. ER were not detectable in any of the studied breasts, while PR were found at a low level in 2 patients with bilateral gynecomas- tia. The authors concluded that the development of AG is probably not mediated by an abnormal increase in ER number. Our results revealed that all glands in men with idiopathic gynecomastia exhibited positive ER and/or PR expression. The discrepancy between our re- sults and the results of Pensler et al. [10] and Lee et al. [11] may result from the fact that the authors described the profile of the receptors in AG (physiological condition) while we analyzed idiopathic gynecomastia“
I understand that people with gyno have higher expression of estrogen receptors, but this seems to indicate that people without gyno do not have these receptors at all? I thought all men will have these receptors but they are not as sensitive In men without gyno? I saw in another study mentioning something about estrogen receptor positive Cells and estrogen receptor negative cells? Does this mean the cells are not expressive in regular males? I’m just so confused
i Am so confused about this one thing, regarding idiopathic gynecomastia, I read a study saying that these men have high expression for estrogen receptors which explains how they can get gyno even with normal estrogen levels.
the Thing that is confusing me is that I read in one study “Pensler et al. [10] examined the expression of estrogen (ER) and progesterone (PR) receptors in breast tissue samples in patients with AG and with Klinefelter syn- drome. The authors found out that none of the patients with AG demonstrated positive expression of ER or PR contrary to those with Klinefelter syndrome. Lee et al. [11] examined the tissue receptor levels in breast tissue re- moved from 7 boys (aged 16–17 years) with AG. ER were not detectable in any of the studied breasts, while PR were found at a low level in 2 patients with bilateral gynecomas- tia. The authors concluded that the development of AG is probably not mediated by an abnormal increase in ER number. Our results revealed that all glands in men with idiopathic gynecomastia exhibited positive ER and/or PR expression. The discrepancy between our re- sults and the results of Pensler et al. [10] and Lee et al. [11] may result from the fact that the authors described the profile of the receptors in AG (physiological condition) while we analyzed idiopathic gynecomastia“
I understand that people with gyno have higher expression of estrogen receptors, but this seems to indicate that people without gyno do not have these receptors at all? I thought all men will have these receptors but they are not as sensitive In men without gyno? I saw in another study mentioning something about estrogen receptor positive Cells and estrogen receptor negative cells? Does this mean the cells are not expressive in regular males? I’m just so confused
