raloxifene

[knoxville79]

I've had puffy nipples since puberty and I've been told to try raloxifene. It really isn't that bad but it seems to be exacerbated when I get some fat on my tits while bulking. FYI, I've never cycled before and plan to start my first in a few weeks. If I end up trying raloxifene, should I wait until PCT and just add it with my tamoxifen?

THANX ALL

 

[MaxRep]

Raloxifene is very similar to nolvadex. Both are SERM's and block estrogen at the receptor in the breast. I'm not sure why you're thinking of adding it to nolvadex.

As for your puffy nipples, you could try raloxifene or nolvadex or any of the AI's and see if that helps. If you actually have any gyno however, none of these things will do much to get rid of it.

Best regards,
MaxRep

 

[knoxville79]

I had just been told that raloxifene had at least a shot at combating pre-existing gyno if it was very light. I have yet to see numbers that either back up this claim or refute it so I was wondering if anyone had tried it for such reasons.

 

[novicebb]

I have also heard that Letrozole can assist with existing gynocomastia. All I can say is try it. I read an article that some people have had some amazing results with nolvadex as far as reducing gyno.

 

[Conciliator]

Raloxifene has been shown to be more effective than nolvadex at blocking estrogen in breast tissue. If you try it, report back and let us know if it helped.

 

[Conciliator]

http://www.ncbi.nlm.nih.gov/entrez/...Retrieve&dopt=abstractplus&list_uids=15238910

J Pediatr. 2004 Jul;145(1):71-6.

Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia.Lawrence SE, Faught KA, Vethamuthu J, Lawson ML.
Department of Pediatrics, University of Ottawa, Ontario, Canada. slawrence@cheo.on.ca

OBJECTIVES: To assess the efficacy of the anti-estrogens tamoxifen and raloxifen in the medical management of persistent pubertal gynecomastia. STUDY DESIGN: Retrospective chart review of 38 consecutive patients with persistent pubertal gynecomastia who presented to a pediatric endocrinology clinic. Patients received reassurance alone or a 3- to 9-month course of an estrogen receptor modifier (tamoxifen or raloxifene). RESULTS: Mean (SD) age of treated subjects was 14.6 (1.5) years with gynecomastia duration of 28.3 (16.4) months. Mean reduction in breast nodule diameter was 2.1 cm (95% CI 1.7, 2.7, P <.0001) after treatment with tamoxifen and 2.5 cm (95% CI 1.7, 3.3, P <.0001) with raloxifene. Some improvement was seen in 86% of patients receiving tamoxifen and in 91% receiving raloxifene, but a greater proportion had a significant decrease (>50%) with raloxifene (86%) than tamoxifen (41%). No side effects were seen in any patients. CONCLUSION: Inhibition of estrogen receptor action in the breast appears to be safe and effective in reducing persistent pubertal gynecomastia, with a better response to raloxifene than to tamoxifen. Further study is required to determine that this is truly a treatment effect.

 

[knoxville79]

Thanks to everyone for the help. I'll go ahead and buy a bottle, run it PCT, and let you all know how it went. I'll probably just use my nolva during cycle to cut down bloat.