NEW YORK (Reuters Health) Mar 30 - The results of a study published in the April issue of the American Journal of Kidney Diseases suggest that resistance training reduces inflammation and improves nutritional status in patients with moderate chronic kidney disease who follow a low-protein diet.
"Systemic inflammation and protein-energy malnutrition may be associated with poor outcomes in kidney disease," Dr. Carmen Castaneda, of Tufts University, Boston, and colleagues write. In a cohort of 26 adults with chronic kidney disease who were not receiving dialysis, they examined the effect of training on inflammatory mediators and the association between inflammatory markers and nutritional and functional parameters.
The subjects were randomly assigned to resistance training or to a control group, which performed stretching and flexibility exercises only, for 12 weeks. The subjects were also counseled to consume a low-protein diet.
Patients who participated in resistance training had reduced C-reactive protein (CRP) levels compared with controls (-1.7 mg/L versus -1.5 mg/L, respectively; p = 0.049). Levels of interleukin-6 (IL-6) were also reduced more in those in the resistance-training program (-4.2 pg/mL) compared with controls (-2.3 pg/mL; p = 0.01).
Resistance training was also associated with skeletal muscle hypertrophy and improved muscle strength compared to controls.
"Although maintenance dialysis therapy and kidney transplantation promote extended survival in kidney failure, these therapies may be less effective in improving nutritional status and quality of life," Dr. Castaneda and colleagues write.
"Therefore, long-term interventions of resistance training should be investigated further as novel therapeutic approaches for this patient population are being considered."
Am J Kidney Dis 2004;43:607-616.
"Systemic inflammation and protein-energy malnutrition may be associated with poor outcomes in kidney disease," Dr. Carmen Castaneda, of Tufts University, Boston, and colleagues write. In a cohort of 26 adults with chronic kidney disease who were not receiving dialysis, they examined the effect of training on inflammatory mediators and the association between inflammatory markers and nutritional and functional parameters.
The subjects were randomly assigned to resistance training or to a control group, which performed stretching and flexibility exercises only, for 12 weeks. The subjects were also counseled to consume a low-protein diet.
Patients who participated in resistance training had reduced C-reactive protein (CRP) levels compared with controls (-1.7 mg/L versus -1.5 mg/L, respectively; p = 0.049). Levels of interleukin-6 (IL-6) were also reduced more in those in the resistance-training program (-4.2 pg/mL) compared with controls (-2.3 pg/mL; p = 0.01).
Resistance training was also associated with skeletal muscle hypertrophy and improved muscle strength compared to controls.
"Although maintenance dialysis therapy and kidney transplantation promote extended survival in kidney failure, these therapies may be less effective in improving nutritional status and quality of life," Dr. Castaneda and colleagues write.
"Therefore, long-term interventions of resistance training should be investigated further as novel therapeutic approaches for this patient population are being considered."
Am J Kidney Dis 2004;43:607-616.
