Reta phase 3 results out

[RockyP]

https://www.fiercebiotech.com/biotech/eli-lillys-obesity-triple-threat-smashes-efficacy-expectations-phase-3-proves-intolerable

I’m waiting for commentary from @Ghoul @Photon and others. They ratcheted these poor bastards up to 12 mg daily. Can’t imagine taking that much. Efficacy was above expectations but so was discontinuation rate (again, 12 mg is nuts).

Lilly has 7 more Reta trials in the works.

 

[dinfaralt]

I'm starting to think that hsCRP is not a good indicator.

you remember me saying shit like i cant tolerate eo and its causing me high crp?

my crp basically crept up from 23 to 47 over 1-2 months and apparently i got hit by a fungus and infection at the same time.

i geniuenly believe its a dogshit marker unless you got inflammation in the body right NOW.

i have my doctor once a year scanning my heart, listening to the rhytm. doing a ekg to make sure nothing is wrong

previous to that my crp has always been 3-5

 

[Photon]

you remember me saying shit like i cant tolerate eo and its causing me high crp?

my crp basically crept up from 23 to 47 over 1-2 months and apparently i got hit by a fungus and infection at the same time.

i geniuenly believe its a dogshit marker unless you got inflammation in the body right NOW.

i have my doctor once a year scanning my heart, listening to the rhytm. doing a ekg to make sure nothing is wrong

You should get an echo, ekg done yearly,
also a full abdominal ultrasound.

keep track of lvh and prostate size

 

[dinfaralt]

You should get an echo, ekg done yearly,
also a full abdominal ultrasound.

i get it all for free, communism denmark 50% taxes woohoo

 

[maxtor]

i get it all for free, communism denmark 50% taxes woohoo

How?

 

[dinfaralt]

How?

i fart like peter griffin if he refuses

 

[New2theGame!!]

I was on 20mg reta. Backed down to 15mg. It stopped lowering my appetite a while ago no matter the dosage. Been on it over a year now.

Any plan to come off to reset receptors? I’m also on a high dose 18mgs a week and plan on increasing. Zero sides at all after getting the skin sensitivity out of the way. Sorry I do think HR has slightly increased.

 

[juicebro]

Any plan to come off to reset receptors? I’m also on a high dose 18mgs a week and plan on increasing. Zero sides at all after getting the skin sensitivity out of the way. Sorry I do think HR has slightly increased.

I tried that. Took a few weeks off. Didn't change anything.

 

[SubparMarioBro]

Also not surprising - EL makes no mention of proportion of lean mass loss. If you calculate the incremental weight loss from reta versus tirz in the Phase 2 studies, it is entirely lean mass on the 8mg+ doses - meaning individuals could actually have lost MORE fat on tirz. (And yes, I understand protein, strength training, etc. I'm talking about the population these medications are actually intended for).

They didn’t do any DEXA scans in Triumph-4 so they have no idea what the proportion of lean mass loss was. You’ll have to wait for Triumph-1 for that data. Most of these trials don’t track it.

The high lean mass loss in the phase 2 vs tirz probably has a lot to do with the fact that they measured at week 36 for reta vs week 72 for tirz. The reta trial was measuring lean mass loss while most of the trial participants were still actively and rapidly losing weight, so their glycogen levels are depleted and water weight is low. On a DEXA scan that’s all lean mass. You’ll see “improvement” as you run the trial out and start plateauing the participants and allowing their water weight to recover.

 

[just some dude]

you remember me saying shit like i cant tolerate eo and its causing me high crp?

my crp basically crept up from 23 to 47 over 1-2 months and apparently i got hit by a fungus and infection at the same time.

i geniuenly believe its a dogshit marker unless you got inflammation in the body right NOW.

i have my doctor once a year scanning my heart, listening to the rhytm. doing a ekg to make sure nothing is wrong

previous to that my crp has always been 3-5

well they say there’s one that tests very sensitive amounts of inflammation for example the heart, and the other one for general inflammation for example from sickness, no?

CRP regular

CRP cardio

i just got blood work for the first time the other day after years of blasting, i have just been asking the robot questions for example what is the difference between those two tests i can order. etc. not trying to do anything but publicly post my research

 

[SnowyMiami]

I was on 20mg reta. Backed down to 15mg. It stopped lowering my appetite a while ago no matter the dosage. Been on it over a year now.

Any plan to come off to reset receptors? I’m also on a high dose 18mgs a week and plan on increasing. Zero sides at all after getting the skin sensitivity out of the way. Sorry I do think HR has slightly increased.

What are you getting out of doses this high? Better body comp?

 

[BP_6]

Lots of interesting data to look over. When you think about it, the glucagon receptor actually technically triggers catabolism. Basically with insulin and glucagon being a yin/yang relationship. I may be wrong, but from what I have seen, I don't think they are really going to market it as a diabetic drug. It is mostly going to be focused on weight loss and MASH.

As for the drug becoming less effective, I don't think that really has anything to do with "receptor burnout." It has been tested to be shown to be effective 2+ years. Gastric emptying and some things improve the longer you are on, but the general appetite effects appear to remain.

The less effective likely has to do with simply two things. 1. As with all dieting, the more weight you lose, the harder it becomes to lose more. 2. The setpoint every person has. The lower your BF becomes, the stronger the hunger response is going to be. At a point, I am sure the reta/tirz will not be able to overcome it as much as it did in the past.

Lol, no real true science in anything I said, just a theory based on logic from what we do know.

 

[MentEFresh]

Just increase the reta dose lol

This seems right, but Sema has like 10x the glp1 binding affinity as Reta. If wanting to more appetite suppresion, Sema is the drug, not Reta. Or cagri.

 

[BP_6]

This may sound odd, but has anyone thought about adding a bit of mazdutide or survodutide? These GLP's are both newer than tirz but they don't get the love as it seems few ever have even tried them. It would be interesting if we had more reports on these two.