Reta vs Tirz

[seelos]

Hey all, I'm very new to this community and I was wondering if anyone could provide some clarification on these two weight loss drugs.

When I first discovered retatrutide it sounded way too good to be true, but after further research it seems to do exactly what it claims with minimal sides (sensitive skin is the only one I've found). However, it seems that most of the experienced people on here still only discuss tirz as the best option.

I am aware that the appetite suppression effects of reta is overall weaker compared to other weight loss drugs, but ever since I did a couple aggressive mini cuts I haven't really had much trouble with not eating. Is the tirz preference just because most people need more appetite suppression, or is there something else that I'm missing?

I'm waiting on a shipment of reta so I can share my experience soon enough.

 

[explodingHeart]

....it used to be much, much worse here.

A year ago if you wanted to be a lightning rod for hate say something positive about GLPs.

As someone who uses both, it was surreal arguing with people who had a regions fundamentalist level of anti-GLP zeal, because exogenous GLP hormones ( that's what they are) are a filthy "cheat" for the weak, while their use of exogenous hormones to achieve the body they want, often at the expense of health, was somehow noble.

The same rationale for anti-steroid hate from normies, "it's cheating!", was used by them against GLPs.

So many BBs have used them now, getting the "food noise gone" epiphany of just how biological the drive to eat is and not an issue of morality, that anti-GLP stuff is pretty rare now.

This is the same community that used to make tren from finaplix pellets. At the very least (the younger crowd), nearly 100% of them used UG tren.

They miraculously starting being accepting of GLPs when bodybuilder influencers started getting paid to promote tele-medicine clinics prescribing (shitty chinese) "compounded" GLPs.

Or how using TRT became mainstream and bodybuilders finally admitted to not being natty when they got paid to promote TRT clinics.

 

[Usman457]

I've used all Tirz for a cut 2 years ago, Nuked my appetite, found it hard to hit my protein goals.

Using Reta currently, not as suppressive but I'm losing the weight and I'm able to hit my 200g of protein a day.

maybe try a mix of the two? I know someone doing 6mg Reta and .25 Sema and says the appetite suppression is better, I might try this too tbh

 

[Ghoul]

This is the same community that used to make tren from finaplix pellets. At the very least (the younger crowd), nearly 100% of them used UG tren.

They miraculously starting being accepting of GLPs when bodybuilder influencers started getting paid to promote tele-medicine clinics prescribing (shitty chinese) "compounded" GLPs.

Or how using TRT became mainstream and bodybuilders finally admitted to not being natty when they got paid to promote TRT clinics.

Before the non-appetite benefits started becoming very clear to nearly every medical speciality, it wasn't unusual to encounter doctors who were ferociously anti-GLP.

A competitive mountain biker doctor of mine(ie, super shredded) FIRED me as a patient when I pulled out a vial to "prove" my NAFLD stage 1 liver disease had been cleared by the Tirz I was using, and not some unexplained "miracle".

I would've gotten a better response if I told him I was shooting heroin, lol.

 

[Ghoul]

I've used all Tirz for a cut 2 years ago, Nuked my appetite, found it hard to hit my protein goals.

Using Reta currently, not as suppressive but I'm losing the weight and I'm able to hit my 200g of protein a day.

maybe try a mix of the two? I know someone doing 6mg Reta and .25 Sema and says the appetite suppression is better, I might try this too tbh

I'm not a fan of mixing GLPs, but adding sema to either is probobly a better choice if you do, than mixing reta and tirz.

This way you're only boosting GLP agonism, the primary appetite suppression mechanism. Tirz and Reta bind to GIP receptors in completely different ways. Tirz replicates the natural hormone. Reta has 8.4x stronger binding to GIP.

You don't want a random "mix" of those two different mechanisms of action on GIP, since the balance Reta has between its supercharged GIP binding and glucagon binding was almost certainly deliberately chosen for safety and efficacy.

Among other things, Reta's super strong GIP binding prevents the metabolic adaptation that occurs as you lose weight. Usually as weight comes off, metabolism slows, making it progressively harder to lose more and easier to put weight back on. You wouldn't gain anything from a weaker 1x Tirz GIP agonist occupying a receptor stronger 8.4x Reta GIP agonist would otherwise be in.

 

[Yugo92]

While sema is very effective for appetite suppression, side effects vary and can be intense.
I personally had a very negative experience with it, even on a low dose.
Just 0.25 mg had me feeling like a zombie, constant fatigue and zero energy.
After three weeks, I threw the whole thing out.

 

[Usman457]

I'm not a fan of mixing GLPs, but adding sema to either is probobly a better choice if you do, than mixing reta and tirz.

This way you're only boosting GLP agonism, the primary appetite suppression mechanism. Tirz and Reta bind to GIP receptors in completely different ways. Tirz replicates the natural hormone. Reta has 8.4x stronger binding to GIP.

You don't want a random "mix" of those two different mechanisms of action on GIP, since the balance Reta has between its supercharged GIP binding and glucagon binding was almost certainly deliberately chosen for safety and efficacy.

Among other things, Reta's super strong GIP binding prevents the metabolic adaptation that occurs as you lose weight. Usually as weight comes off, metabolism slows, making it progressively harder to lose more and easier to put weight back on. You wouldn't gain anything from a weaker 1x Tirz GIP agonist occupying a receptor stronger 8.4x Reta GIP agonist would otherwise be in.

Ahh good to know, yeah I think the only one I would mix is Sema too, but I'm only on Reta atm, as it get leaner I will probably try adding in that sema though

 

[Photon]

Personally, I wouldn't mix GLP-1's, but if I had to, I would probably pick something like Maz, or survo to mix with my tirz. Both those compounds are showing very good results in trials and are kind of left in the dark with tirz and reta taking up all the spotlight.

It's cause of prices.
It's significantly (a few times) more expensive to follow clinical dosing protocols on maz/survo vs sema/tirz/reta.

There are new GLPs coming out which I'm more interested in, but I highly doubt it will be cost effective to run them for a really really long time...

 

[Here2Learn]

Reta has been the best option for me, I have better energy on it than the other two. I had better inflammation control on Sema than either of the other two though. I prefer the way I actually get hungry on Reta and want to eat, now you might feel really full mid bite but hitting macros is a lot easier.

I also don’t like the idea of mixing, if I was to add anything it would be Sema to Reta but I think Tirz and Reta isn’t a solid option. The data starting to come out of the Reta trials at 12mg for health benefits has been pretty great. Also, Tirz is better dosed at 5 or 6 days while Reta shines at 7 days. Sema and Tirz is a 4 week escalation unless sides or you are losing weight. Reta is a dose up every 4 weeks regardless of weight loss due to health benefits at 12mg. I personally started having sides at 6mg and didn’t feel good for a couple days after dosing. I’ve been off for 6 weeks and starting back, did it for some other protocols and tracking symptoms. No sides so far but still at 2mg.

 

[Redhand97]

Is reta available in Europe?

Yes only ugl peptide seller etc

 

[Bigmike806]

I'm not a fan of mixing GLPs, but adding sema to either is probobly a better choice if you do, than mixing reta and tirz.

This way you're only boosting GLP agonism, the primary appetite suppression mechanism. Tirz and Reta bind to GIP receptors in completely different ways. Tirz replicates the natural hormone. Reta has 8.4x stronger binding to GIP.

You don't want a random "mix" of those two different mechanisms of action on GIP, since the balance Reta has between its supercharged GIP binding and glucagon binding was almost certainly deliberately chosen for safety and efficacy.

Among other things, Reta's super strong GIP binding prevents the metabolic adaptation that occurs as you lose weight. Usually as weight comes off, metabolism slows, making it progressively harder to lose more and easier to put weight back on. You wouldn't gain anything from a weaker 1x Tirz GIP agonist occupying a receptor stronger 8.4x Reta GIP agonist would otherwise be in.

I see what you're saying, thanks for the info.

 

[pengpent]

Nothing proven, and I don't think it should be considered unless the max dose of a single compound proves insufficient. Even then, Sema and Tirz have increased doses(for poor responders) on the verge of approval, and are demonstrated safe. Up to 25mg Tirz and incredibly, 7.2mg sema. So there's more room for those compounds to be increased.

If someone feels like they must use an add on to Tirz or Reta, imo a tiny dose of Sema is the best route.

This way you're only boosting GLP agonism, the main appetite suppression mechanism, and not competing for GIP receptors against Reta or Tirz. GIP agonism varies greatly between these compounds. I wouldn't want to block a GIP receptor with Tirz, which replicates natural binding strength, from Reta which is 8x stronger when the difference is likely an important part of the "balance" in each of those compound's formula. .

@Ghoul out of curiosity, can you point me where I can find details about higher dosed studies? Thanks

 

[Ghoul]

@Ghoul out of curiosity, can you point me where I can find details about higher dosed studies? Thanks

Sema 7.2:

ClinicalTrials.gov

clinicaltrials.gov

I can't find the Zepbound larger dose info at the moment. It had been an extended arm of the ongoing long term trials Eli Lily is conducting, but for some reason I'm not seeing it. If I find it I'll post it.

 

[Proud Pangolin]

Personally I think if you're using anything above physiologic doses of rHGH, it's foolish not to run a GLP to keep the strain off your beta cells. I can see the effects of growth hormone induced insulin resistance on my CGM, but glucose clearance post meal is very sharp and Tirz keeps me in a tight range consistently. I'm confident I could go long term without inducing pre-diabetes thanks to the protection the GLP provides.

And here am i, not ihtetested in the.GLP action at all but only in the GIP ane Glucagon action for its fatburning effect

 

[Ghoul]

And here am i, not ihtetested in the.GLP action at all but only in the GIP ane Glucagon action for its fatburning effect

Reta seems to be GLP that provides the ancillary benefits at doses that don't induce much appetite suppression for most. The unofficial "bodybuilder's GLP".

 

[Nunya]

I'm not a fan of mixing GLPs, but adding sema to either is probobly a better choice if you do, than mixing reta and tirz.

This way you're only boosting GLP agonism, the primary appetite suppression mechanism. Tirz and Reta bind to GIP receptors in completely different ways. Tirz replicates the natural hormone. Reta has 8.4x stronger binding to GIP.

You don't want a random "mix" of those two different mechanisms of action on GIP, since the balance Reta has between its supercharged GIP binding and glucagon binding was almost certainly deliberately chosen for safety and efficacy.

Among other things, Reta's super strong GIP binding prevents the metabolic adaptation that occurs as you lose weight. Usually as weight comes off, metabolism slows, making it progressively harder to lose more and easier to put weight back on. You wouldn't gain anything from a weaker 1x Tirz GIP agonist occupying a receptor stronger 8.4x Reta GIP agonist would otherwise be in.

So if one were to switch, Tirz to Reta, transition or cold turkey?

 

[Ghoul]

So if one were to switch, Tirz to Reta, transition or cold turkey?

I'd just start Reta the following week after ending Tirz, at the equivalent position on the dose hierarchy. IE, Tirz 2.5-15 vs Reta 2-12.

 

[Dirthand]

I'd just start Reta the following week after ending Tirz, at the equivalent position on the dose hierarchy. IE, Tirz 2.5-15 vs Reta 2-12.

So say a person has been on triz for a while and they were at 7.5mg and wanted to switch to reta.... would they start at the lowest starting point of reta (2mg) or would they need to kinda match the triz dose they were at?

 

[Nunya]

So say a person has been on triz for a while and they were at 7.5mg and wanted to switch to reta.... would they start at the lowest starting point of reta (2mg) or would they need to kinda match the triz dose they were at?

His reply indicated to step across to the same step on the scale. The tirz scale is 2.5-5-7.5-10-12.5-15 and iirc Reta is 2-4-6-8-10-12. So if you're at 5 on tirz you could theoretically step across to 4 on reta

 

[Dirthand]

His reply indicated to step across to the same step on the scale. The tirz scale is 2.5-5-7.5-10-12.5-15 and iirc Reta is 2-4-6-8-10-12. So if you're at 5 on tirz you could theoretically step across to 4 on reta

Cool thanks for clarifying, I know someone who was wanting to go the reta route but she was thinking she would start reta at 2 after being on triz at 7.5 triz. In actuality she would probably need to start reta at 6 if I understand correctly.
Thanks doll

 

[Ghoul]

So say a person has been on triz for a while and they were at 7.5mg and wanted to switch to reta.... would they start at the lowest starting point of reta (2mg) or would they need to kinda match the triz dose they were at?

You could start at the bottom but you certainly don't have to, and if you do, I'd expect a major appetite rebound within a couple of weeks. In fact I'd say rebound is the bigger risk than too much appetite
suppression for you, as a long term stable Tirz user.

People on pharma are switched from Sema to Tirz all the time, and while there's no official guidance, the same philosophy is followed (slightly lower on Tirz dose level because Tirz maxes out at higher weight loss, so level 4 on Sema, 1mg, would be level 3 on Tirz, 7.5).

Tirz 7.5 is 3rd level (2.5-5-7.5-10-12.5-15). Reta is 1,2,4,8,12 (1 may be eliminated when it goes to market).

Based on this, you could conservatively start at 4. If a week later you're getting strong appetite rebound, I'd go to 6 (not an "official dose"), or just straight to 8, which is what pharma patients using fixed dose pens will be doing when they move up from 4, so you know 4 to 8 isn't the type of jump that's going to cause significant problems if 4 is tolerable.