Reta worked great for me at 8mg, then my appetite came back.

[Zaxes]

I used to do "large" dose of tirz, about 14 mg before switching to reta, and I finally experienced the effect at 8 mg and it was GREAT.
Now, however, the craving came back, not as strong but it does bother me lol.


I do want to drop another 15 pounds to be somewhat happy. I am thinking if I should slowly keep increasing the dose up to the maximum OR if I should do a bit of Cagrilintide.

Anyone have similar experience or what did you do? Thanks

 

[PrairieSteel]

I noticed a profound i crease in efficacy when I increased from 8mg to 10mg split weekly. I actually had to reduce back to 8mg as I was co sisterly missing macro goals. Now I am back at 6mg.

I would personally titrate up to 12mg reta before considering adding another compound.

 

[Zaxes]

How does your split dose look like? Twice per week half the dose?

 

[PrairieSteel]

Yes sir, that is correct.

So currently at 6mg weekly I take 3mg on Monday and 3mg on Thursday.

 

[BALLISTIC]

I used to do "large" dose of tirz, about 14 mg before switching to reta, and I finally experienced the effect at 8 mg and it was GREAT.
Now, however, the craving came back, not as strong but it does bother me lol.


I do want to drop another 15 pounds to be somewhat happy. I am thinking if I should slowly keep increasing the dose up to the maximum OR if I should do a bit of Cagrilintide.

Anyone have similar experience or what did you do? Thanks

Can I ask what your dosing looks like?

For reference, I run 10 mg once weekly on Sundays. I titrated up 1mg per week. The pharmacokinetics support weekly dosing, even though a lot of people split it up and argue for multiple injections. I stick with what the science supports so far.

My pattern is very consistent with Sunday injection. By Monday evening I feel it fully come online. Tuesday/Thursday appetite suppression is strong. Friday I start to feel a slight return. Saturday I’m noticeably hungrier. Sunday I re+dose.

So realistically, I only need real discipline for about a day and a half each week.
Because of that, I can comfortably get by on protein shakes and meal replacements, plus one solid, nutritious meal per day. Retatrutide doesn’t kill my desire for food, it regulates it. I still enjoy food and even crave junk sometimes, but after a few bites I’m satisfied. The urge to clear the plate just isn’t there anymore.