Retatrutide

[gotgrowth]

Looking to start retatrutide a source I’m looking to buy from had 10,15 and 20mg. But his 10mg came in at 97 percent purity while his 15 and 20 came in at 99

My question if i start at 2mg a week will the 15mg last once reconstituted for 8 weeks ish ?

 

[Ghoul]

By the time the peptide gets to you, the 99% could be 94% and the 97% could still be 97%, so don't concern yourself too much with that. 96% or above imo is fine.

Pharma reconstituted GLPs (pens) last for two years under refrigeration. That's under perfect conditions you cannot replicate.

User reconstituted pharma proteins in multi dose containers, using the specific BAC they supply, are universally instructed to be discarded after 28 days.

No one can say for certain how long before a UGL peptide degrades. On top of all the variables, each batch will vary in stability as well.

What you can do to maximize its life is the following.

-Use real pharma grade BAC like Hospira.

-Use high quality syringes, like BD, to minimize the amount of silicone lubricant introduced into the vial when reconstituting. Silicone droplets promote degradation.

-Dilute to the same ratio used by pharma, or more, but never less.

-Exercise discipline in wiping vial top every time with an alcohol swab, and allow to dry, so you minimize introducing more bacteria.

-Of course refrigerate, protect the vial from light in an opaque container.

-Allow the reconstituted solution, in its opaque container, to come to room temp, 10 minutes or so before opening the outer container and using. This will prevent bacteria laden condensation from forming on the vial.

-Minimize vial agitation after reconstitution. Don't keep it in a refrigerator drawer that's frequently opened, for instance.



The more of these steps you follow, the longer Reta, or any reconstituted peptide will last.

Doing what you can / are willing to is better than not doing any of them.

All of that said, 7-8 weeks is rarely a problem, but it's always a good idea to protect as much potency as you can anyway. The products of protein degradation can have other undesirable effects.

For the truly obsessed:

-If you're really intent on doing everything possible to minimize any potential source of degradation, use a .2 or .22 PES low protein adhesion syringe filter and transfer the reconstituted solution into a sterile, pyrogen free container, at the cost of some product.

-Finally, the ultimate you can do to ensure you're injecting the best version of the peptide is to syringe filter the dose into the syringe just before administration.

 

[gotgrowth]

By the time the peptide gets to you, the 99% could be 94% and the 97% could still be 97%, so don't concern yourself too much with that. 96% or above imo is fine.

Pharma reconstituted GLPs (pens) last for two years under refrigeration. That's under perfect conditions you cannot replicate.

User reconstituted pharma proteins in multi dose containers, using the specific BAC they supply, are universally instructed to be discarded after 28 days.

No one can say for certain how long before a UGL peptide degrades. On top of all the variables, each batch will vary in stability as well.

What you can do to maximize its life is the following.

-Use real pharma grade BAC like Hospira.

-Use high quality syringes, like BD, to minimize the amount of silicone lubricant introduced into the vial when reconstituting. Silicone droplets promote degradation.

-Dilute to the same ratio used by pharma, or more, but never less.

-Exercise discipline in wiping vial top every time with an alcohol swab, and allow to dry, so you minimize introducing more bacteria.

-Of course refrigerate, protect the vial from light in an opaque container.

-Allow the reconstituted solution, in its opaque container, to come to room temp, 10 minutes or so before opening the outer container and using. This will prevent bacteria laden condensation from forming on the vial.

-Minimize vial agitation after reconstitution. Don't keep it in a refrigerator drawer that's frequently opened, for instance.



The more of these steps you follow, the longer Reta, or any reconstituted peptide will last.

Doing what you can / are willing to is better than not doing any of them.

All of that said, 7-8 weeks is rarely a problem, but it's always a good idea to protect as much potency as you can anyway. The products of protein degradation can have other undesirable effects.

For the truly obsessed:

-If you're really intent on doing everything possible to minimize any potential source of degradation, use a .2 or .22 PES low protein adhesion syringe filter and transfer the reconstituted solution into a sterile, pyrogen free container, at the cost of some product.

-Finally, the ultimate you can do to ensure you're injecting the best version of the peptide is to syringe filter the dose into the syringe just before administration.

Wow thank you for all that info that’s more than i have gotten out of any source I’ve ever talked to

 

[DeeX]

Phase 3 trial dosage is 2, 4, 6, 9, 12 mg btw.

 

[Ghoul]

Phase 3 trial dosage is 2, 4, 6, 9, 12 mg btw.

Do me a solid and find out what the dilution rates are for each dose, if you can. If it's in the Phase II or III documentation, it's firmed up and will be what's used for retail. I'm just spent when it comes to looking shit up.

 

[Rawbie]

im starting .5mg EOD.. just started today.

 

[Ghoul]

im starting .5mg EOD.. just started today.

Out of curiosity, what's your goal?

 

[Rawbie]

Out of curiosity, what's your goal?

Drop body fat. I am dosing it low to assess side effects probably keep it like this 2-4 weeks before titrating up.
so far I feel *a little* warmer

Also curious about other affects.. I got a CGM (just out of my own curiosity and to see how my body reacts to certain foods) but its going to be interesting to see if/how reta affects my blood glucose

 

[Rawbie]

Out of curiosity, what's your goal?

Are you taking it / planning to take it?

 

[Ghoul]

Are you taking it / planning to take it?

If looks good so far, but Tirz is working well for me, so I'm willing to be patient. At least until FDA approval which seems imminent . I'm not looking for more weight loss, so I want to see how the other health benefits look in comparison to Tirz.

 

[Rawbie]

If looks good so far, but Tirz is working well for me, so I'm willing to be patient. At least until FDA approval which seems imminent . I'm not looking for more weight loss, so I want to see how the other health benefits look in comparison to Tirz.

im curious too about anti inflammatory / mental etc.. I dont have tirz to compare it too.. I did a round of sema a while back. Im not FAT. Walk around ~215 around probably 18-20% bf after a long time off the gym and my appetite is out of control though, so figured it use it as a tool and see the other benefits that come from it as I cut weight

 

[Ghoul]

im curious too about anti inflammatory / mental etc.. I dont have tirz to compare it too.. I did a round of sema a while back. Im not FAT. Walk around ~215 around probably 18-20% bf after a long time off the gym and my appetite is out of control though, so figured it use it as a tool and see the other benefits that come from it as I cut weight

Hey man no judgement from me. Sooner or later a simple test may very well prove you produce too little GLP inducing a chronically elevated appetite. I'm not one of the crowd desperate to prove my superiority by insisting weight is entirely a matter of willpower without any basis in biology whatsoever. Relieving the pressure of excess cravings is taking action to improve your health, not something that's a sign of weakness.

 

[Rawbie]

Hey man no judgement from me. Sooner or later a simple test may very well prove you produce too little GLP inducing a chronically elevated appetite. I'm not one of the crowd desperate to prove my superiority by insisting weight is entirely a matter of willpower without any basis in biology whatsoever. Relieving the pressure of excess cravings is taking action to improve your health, not something that's a sign of weakness.

Well I'll keep updated on results.

This morning I weighed in at 213.3 and scale showing 14.9% (for what it's worth lol). my diet has been on point and I tend to lean out pretty quickly so I am curious to see how this affects all of that.

 

[Ghoul]

Well I'll keep updated on results.

This morning I weighed in at 213.3 and scale showing 14.9% (for what it's worth lol). my diet has been on point and I tend to lean out pretty quickly so I am curious to see how this affects all of that.

I'd encourage you to go to once a week dosing, following the clinical trial dosing protocol once you're comfortable you're not going to have a bad reaction. The pharma protocol has been proven to be extremely effective.

You can see the percentage of subjects experiencing adverse effects at different dosages.

https://www.hearmenowstories.org/images/lancet-retatrutide.pdf

 

[Rawbie]

I'd encourage you to go to once a week dosing, following the clinical trial dosing protocol once you're comfortable you're not going to have a bad reaction. The pharma protocol has been proven to be extremely effective.

You can see the percentage of subjects experiencing adverse effects at different dosages.

View attachment 300733

https://www.hearmenowstories.org/images/lancet-retatrutide.pdf

thanks for that study! Ill assess this low dose and based off this bump it to 4mg next week and assess from there

 

[Trenbolonetax]

Hey man no judgement from me. Sooner or later a simple test may very well prove you produce too little GLP inducing a chronically elevated appetite. I'm not one of the crowd desperate to prove my superiority by insisting weight is entirely a matter of willpower without any basis in biology whatsoever. Relieving the pressure of excess cravings is taking action to improve your health, not something that's a sign of weakness.

No Ghoul, you have to suffer or it doesn’t count. Come on, bro!

/s

 

[Rawbie]

No Ghoul, you have to suffer or it doesn’t count. Come on, bro!

/s

that seems to be the majority consensus since Ive been browsing these forums lol.. if you use GLP1 you're fat and undisciplined...

nah bro, they're tools to be used.

@Trenbolonetax I believe in my reading youre dosing this on the higher end? can you tell me what you started at and what you've experienced? thanks!

 

[Ghoul]

No Ghoul, you have to suffer or it doesn’t count. Come on, bro!

/s

Heard from someone today having a really rough start, and I found myself thinking "Yeah, this is the "easy" way" people unwilling to sacrifice anything take, right? lol.

 

[Trenbolonetax]

that seems to be the majority consensus since Ive been browsing these forums lol.. if you use GLP1 you're fat and undisciplined...

nah bro, they're tools to be used.

@Trenbolonetax I believe in my reading youre dosing this on the higher end? can you tell me what you started at and what you've experienced? thanks!

Yessir! I am using 12mg per week.

I started with tirzepatide January 2023. Got to the full 15mg dose in several months. Stayed there for a long time. Then added Reta in somewhere in early 2024. Was doing some of each.

Tirz worked incredibly well to control my BG on high GH. However, I felt like I experienced a bit of lethargy on it and based on my blood ketone levels, it appears to be anti ketogenic.

I run a weird modified ketogenic diet most of the time when I’m not eating like an asshole around the holidays. So, I decided to give Reta solo a shot.

I escalated pretty quickly on Reta solo because I definitely had cross tolerance from tirz. Don’t copy me on that lol.

What have I experienced with Reta? It took longer for the appetite suppression to kick in than I expected but it’s definitely there. Very comparable to tirz, in a somewhat different way.

I don’t get as much reduced gastric motility on Reta compared to tirz which I love. I do get a bit more heart burn / acid if I eat shitty though, but that’s really rare. Reta appears to be pro ketogenic; my ketone levels are elevated more so than not being on any GLP1. I don’t get the same lethargic feeling I was getting from tirz. I can pass up food much easier on either drug. Less food focused altogether.

That’s a pretty quick summary / run down of my experience. Lmk if you’ve got any other questions!

 

[deadbeef]

thanks for that study! Ill assess this low dose and based off this bump it to 4mg next week and assess from there

I'd go to 2mg next. The study above was the phase II trial. In the phase III, the titration was 2,4,6,9,12. I started at 2, currently at 6 and about to go to 9.