Retatrutide

[gotgrowth]

Looking to start retatrutide a source I’m looking to buy from had 10,15 and 20mg. But his 10mg came in at 97 percent purity while his 15 and 20 came in at 99

My question if i start at 2mg a week will the 15mg last once reconstituted for 8 weeks ish ?

 

[Avies48]

Yessir! I am using 12mg per week.

I started with tirzepatide January 2023. Got to the full 15mg dose in several months. Stayed there for a long time. Then added Reta in somewhere in early 2024. Was doing some of each.

Tirz worked incredibly well to control my BG on high GH. However, I felt like I experienced a bit of lethargy on it and based on my blood ketone levels, it appears to be anti ketogenic.

I run a weird modified ketogenic diet most of the time when I’m not eating like an asshole around the holidays. So, I decided to give Reta solo a shot.

I escalated pretty quickly on Reta solo because I definitely had cross tolerance from tirz. Don’t copy me on that lol.

What have I experienced with Reta? It took longer for the appetite suppression to kick in than I expected but it’s definitely there. Very comparable to tirz, in a somewhat different way.

I don’t get as much reduced gastric motility on Reta compared to tirz which I love. I do get a bit more heart burn / acid if I eat shitty though, but that’s really rare. Reta appears to be pro ketogenic; my ketone levels are elevated more so than not being on any GLP1. I don’t get the same lethargic feeling I was getting from tirz. I can pass up food much easier on either drug. Less food focused altogether.

That’s a pretty quick summary / run down of my experience. Lmk if you’ve got any other questions!

How is reta compared to tirz when it comes to gh and blood sugar??

 

[Rawbie]

I'd go to 2mg next. The study above was the phase II trial. In the phase III, the titration was 2,4,6,9,12. I started at 2, currently at 6 and about to go to 9.

that looks to be my next move.. got more reta on the way also

 

[Trenbolonetax]

How is reta compared to tirz when it comes to gh and blood sugar??

Not as good, in my experience. However, this is just based off of BG point in time readings, and not like A1C or anything like that.

Just based on it's glucagon action, I would expect it to not be as good at controlling BG. Since they give glucagon to type 1 diabetics (injected) when they are at stupidly low BG and need to go up NOW.

 

[Avies48]

Not as good, in my experience. However, this is just based off of BG point in time readings, and not like A1C or anything like that.

Just based on it's glucagon action, I would expect it to not be as good at controlling BG. Since they give glucagon to type 1 diabetics (injected) when they are at stupidly low BG and need to go up NOW.

But it did help to keep it somewhat regular??

 

[Ghoul]

But it did help to keep it somewhat regular??

It's as effective as delaglutide(trulicity) for diabetes, but not as good as Sema/Tirz. I doubt it'll be marketed for diabetes.

 

[SpicyMeatball]

Yessir! I am using 12mg per week.

I started with tirzepatide January 2023. Got to the full 15mg dose in several months. Stayed there for a long time. Then added Reta in somewhere in early 2024. Was doing some of each.

Tirz worked incredibly well to control my BG on high GH. However, I felt like I experienced a bit of lethargy on it and based on my blood ketone levels, it appears to be anti ketogenic.

I run a weird modified ketogenic diet most of the time when I’m not eating like an asshole around the holidays. So, I decided to give Reta solo a shot.

I escalated pretty quickly on Reta solo because I definitely had cross tolerance from tirz. Don’t copy me on that lol.

What have I experienced with Reta? It took longer for the appetite suppression to kick in than I expected but it’s definitely there. Very comparable to tirz, in a somewhat different way.

I don’t get as much reduced gastric motility on Reta compared to tirz which I love. I do get a bit more heart burn / acid if I eat shitty though, but that’s really rare. Reta appears to be pro ketogenic; my ketone levels are elevated more so than not being on any GLP1. I don’t get the same lethargic feeling I was getting from tirz. I can pass up food much easier on either drug. Less food focused altogether.

That’s a pretty quick summary / run down of my experience. Lmk if you’ve got any other questions!

I’m in a similar situation right now. About 7 weeks into reta, coming off of 15mg tirz which i tapered down during the same 7 weeks. Am presently taking 6mg every 4 days, so nearly equivalent to 12mg/wk, and the suppression is quite mild. Everyone keeps saying it takes a while to kick i am becoming skeptical. How long did it take for you to really see it working?

 

[Trenbolonetax]

I’m in a similar situation right now. About 7 weeks into reta, coming off of 15mg tirz which i tapered down during the same 7 weeks. Am presently taking 6mg every 4 days, so nearly equivalent to 12mg/wk, and the suppression is quite mild. Everyone keeps saying it takes a while to kick i am becoming skeptical. How long did it take for you to really see it working?

How long have you been taking 6mg every 4 days? Enough time for that dose to stabilize?

I might try a single 12mg dose if the split isn’t working for you.

The appetite suppression from Reta feels different for me than Tirz. I can’t really explain it. I can eat more on Reta without getting uncomfortable but the reduction in drive to eat is just the same.

 

[Rawbie]

I just took 1mg today.

Starting 2 next week. My appetite was weird. I had no real urge to eat. I mean I got hungry but I could have done without food. Hard to explain.

 

[DeeX]

How long have you been taking 6mg every 4 days? Enough time for that dose to stabilize?

I might try a single 12mg dose if the split isn’t working for you.

The appetite suppression from Reta feels different for me than Tirz. I can’t really explain it. I can eat more on Reta without getting uncomfortable but the reduction in drive to eat is just the same.

For me, it didn't work until it hit like a truck. Took ~9 weeks to fully kick in, and it's been kickin' for months since.

I need to drink protein shakes throughout the day to reach my calories.

 

[Trenbolonetax]

For me, it didn't work until it hit like a truck. Took ~9 weeks to fully kick in, and it's been kickin' for months since.

I need to drink protein shakes throughout the day to reach my calories.

Yeah, agreed. It wasn't there. And then, one day I woke up, and it was THERE.

 

[Rawbie]

Going to monitor BG as I increase Reta

 

[noteablequotable]

I just took 1mg today.

Starting 2 next week. My appetite was weird. I had no real urge to eat. I mean I got hungry but I could have done without food. Hard to explain.

I think I'm experiencing something similar. Even though I'm hungry I just don't really feel like eating. It's like my drive to meet that particular need has a damper on it.

 

[Trenbolonetax]

I think I'm experiencing something similar. Even though I'm hungry I just don't really feel like eating. It's like my drive to meet that particular need has a damper on it.

Yeah, that is how I would describe Reta appetite suppression compared to Tirz. Can eat, but drive to eat much lower.

 

[Rawbie]

I think I'm experiencing something similar. Even though I'm hungry I just don't really feel like eating. It's like my drive to meet that particular need has a damper on it.

Yup. Exactly that. Easier to turn down food lol

 

[juicebro]

Started reta a week ago at 0.75mg per day which would be around 5mg per week. Not sure I feel anything yet. I half expected to feel something during the first week and then lower it to 2.5mg but there seems no point now. I only started it that high because I have experience with pharma liraglutide and it did absolutely nothing at the highest dosage (3mg per day or more).

I'm not even looking to drop much weight as I'm already very lean. Maybe a couple of kgs. Getting rid of the urge to binge would be the goal.

 

[Kiraa710]

Anyone combining Tirz and Reta?

 

[Ghoul]

Started reta a week ago at 0.75mg per day which would be around 5mg per week. Not sure I feel anything yet. I half expected to feel something during the first week and then lower it to 2.5mg but there seems no point now. I only started it that high because I have experience with pharma liraglutide and it did absolutely nothing at the highest dosage (3mg per day or more).

I'm not even looking to drop much weight as I'm already very lean. Maybe a couple of kgs. Getting rid of the urge to binge would be the goal.

Daily? Why?

 

[Trenbolonetax]

Anyone combining Tirz and Reta?

I did. I would just choose one or the other, personally. And it depends what goal is IMO which to choose.

 

[Trenbolonetax]

Daily? Why?

Agreed. I’ve had better results doing less frequent larger bolus.

 

[juicebro]

Daily? Why?

Seemed like a smart way to ease into it. I heard people complain they can feel the effects wear off in the second half of the week so daily injections should result in less sides and more stable levels. Weekly administration is probably more about patient compliance rather than the most optimal way to do it like with trt. According to my script I should be injecting 250mg every 3 weeks...

Daily vs weekly blood levels.