MESO-Rx

Anabolic Steroids

Retatrutide

gotgrowth

gotgrowth

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10+ Year Member
Looking to start retatrutide a source I’m looking to buy from had 10,15 and 20mg. But his 10mg came in at 97 percent purity while his 15 and 20 came in at 99

My question if i start at 2mg a week will the 15mg last once reconstituted for 8 weeks ish ?
 
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juicebro said:
Seemed like a smart way to ease into it. I heard people complain they can feel the effects wear off in the second half of the week so daily injections should result in less sides and more stable levels. Weekly administration is probably more about patient compliance rather than the most optimal way to do it like with trt. According to my script I should be injecting 250mg every 3 weeks...

Daily vs weekly blood levels.

View attachment 301235
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It's not a fucking testosterone injection that you wanna have the most stable level.

Enjoy the possible almost certain future side effects
 
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Sampei said:
It's not a fucking testosterone injection that you wanna have the most stable level.

Enjoy the possible almost certain future side effects
Click to expand...
At least respond with an intelligent rebuttal. You don't come off very smart with those angry ramblings. Just because you're fat and miserable doesnt make you an expert on these drugs. Neither does your post count. It just shows you spend all your time on an internet forum and we all know what this translates to in terms of an actual physique.

Daily injections make sense. No peaks and valleys you stay above the threshold dosage without needlessly upping the dosage. You get more out of less. Hunger won't come back towards the end of the week and you won't have more sides when it peaks.
 
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juicebro said:
At least respond with an intelligent rebuttal. You don't come off very smart with those angry ramblings. Just because you're fat and miserable doesnt make you an expert on these drugs. Neither does your post count. It just shows you spend all your time on an internet forum and we all know what this translates to in terms of an actual physique.

Daily injections make sense. No peaks and valleys you stay above the threshold dosage without needlessly upping the dosage. You get more out of less. Hunger won't come back towards the end of the week and you won't have more sides when it peaks.
Click to expand...

I think what the other poster was trying to say (though not with as much tact as was perhaps required) is that while there are fewer peaks and valleys we don't have any data about the impact of injecting these particular peptides every day. People get frustrated sometimes because there are established protocols that we have a lot of information about and no one seems to want to follow them .

I suspect @Ghoul might also have some thoughts about immunogenicity, and how the injecting grey market peptides daily might solicit a stronger immune response (if they aren't well manufactured and sterile).
 
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juicebro said:
At least respond with an intelligent rebuttal. You don't come off very smart with those angry ramblings. Just because you're fat and miserable doesnt make you an expert on these drugs. Neither does your post count. It just shows you spend all your time on an internet forum and we all know what this translates to in terms of an actual physique.

Daily injections make sense. No peaks and valleys you stay above the threshold dosage without needlessly upping the dosage. You get more out of less. Hunger won't come back towards the end of the week and you won't have more sides when it peaks.
Click to expand...

It makes sense if you think every drug is like Testosterone. When all you've got is a hammer(head), everything looks like a nail.

Immunogenicity is the propensity of a protein based drug, like a peptide, to induce an unwanted anti-drug neutralizing effect, making it less effective. It's an enormous area of concern to the FDA and every single pharma peptide development process focuses on it. After demonstrating a certain drug, at a certain dose, using a certain frequency of administration, in a particular container, doesn't cause too much immunogenicity, if anything is changed, they have to prove it all over again. Once a week is the frequency that's been proven with all the GLP drugs to keep immunogenicity to a manageable level.

You can become somewhat, or even completely immune to the drug. You can become immune to the hormone it's mimicking. It may be short term, or permanent, like any other vaccine, because it's the same process going on.

So while you believe the hundreds of millions spent every year to ensure immunogenicity doesn't result in damage to health is meaningless BS, and your "bro science" method must be better, go for it.

These drugs are effective in 99% of cases for rapid, long term, weight loss, following the pharma protocols tested on thousands of subjects., yet somehow that's not good enough for you. You need a special, custom protocol dictated by your "feels". Do what the fuck you like, I'll enjoy reading about clowns like you who develop crazy metabolic disorders down the line because you stimulated your immune system into attacking your natural hormones, but try not to spread the disease of harmful practices, especially as it's for no benefit since the proven safe protocol works just fine. MESO is about HARM REDUCTION.


"Typically, repeated administration is more immunogenic than a single dose, and immunogenicity increases with more frequent dosing and longer-term treatment."

 
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Ghoul said:
It makes sense if you think every drug is like Testosterone. When all you've got is a hammer(head), everything looks like a nail.

Immunogenicity is the propensity of a protein based drug, like a peptide, to induce an unwanted anti-drug neutralizing effect, making it less effective. It's an enormous area of concern to the FDA and every single pharma peptide development process focuses on it. After demonstrating a certain drug, at a certain dose, using a certain frequency of administration, in a particular container, doesn't cause too much immunogenicity, if anything is changed, they have to prove it all over again. Once a week is the frequency that's been proven with all the GLP drugs to keep immunogenicity to a manageable level.

You can become somewhat, or even completely immune to the drug. You can become immune to the hormone it's mimicking. It may be short term, or permanent, like any other vaccine, because it's the same process going on.

So while you believe the hundreds of millions spent every year to ensure immunogenicity doesn't result in damage to health is meaningless BS, and your "bro science" method must be better, go for it.

These drugs are effective in 99% of cases for rapid, long term, weight loss, following the pharma protocols tested on thousands of subjects., yet somehow that's not good enough for you. You need a special, custom protocol dictated by your "feels". Do what the fuck you like, I'll enjoy reading about clowns like you who develop crazy metabolic disorders down the line because you stimulated your immune system into attacking your natural hormones, but try not to spread the disease of harmful practices, especially as it's for no benefit since the proven safe protocol works just fine. MESO is about HARM REDUCTION.


"Typically, repeated administration is more immunogenic than a single dose, and immunogenicity increases with more frequent dosing and longer-term treatment."

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Aye thanks for sharing that!
 
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Yea started Retatrutide 3mg yesterday midnight chest day today pumps close to insulin yet nearly cramp like really cool will check lab work blood sugar cholesterol heart rate onward
 
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zpped said:
What is the reasoning that volume matters regardless of concentration?
Click to expand...

Because it determines the pharmacokinetic properties of the drug.

In other words, the rate at which the dose is absorbed. A smaller volume will reach maximum blood concentration more quickly, a larger volume more slowly.
 
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@Ghoul
Get a life bro. My daily dosing has been working well for me. Zero sides and constant appetite suppression. Stop making dumb shit up. I am not one of those obese folks who these studies were done on. I'm a bodybuilder.

I decided on daily dosing after reading about countless people complaining about the ups and downs and guess fucking what. It has been working perfectly fine.

I do wonder, are you perhaps crippled and unable to leave your home or something that you spend all your time on here? Nobody successful in life spends all their energy arguing with random people on the internet.

The same I said to Sampei applies to you as well. Show yourself. Your physique is the most credible aspect of your knowledge. Show me what applying all that great knowledge has gotten you and I will do the same. No? I didn't think so. So keep your fucking mouth shut and stop giving advice.
 
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juicebro said:
@Ghoul
Get a life bro. My daily dosing has been working well for me. Zero sides and constant appetite suppression. Stop making dumb shit up. I am not one of those obese folks who these studies were done on. I'm a bodybuilder.

I decided on daily dosing after reading about countless people complaining about the ups and downs and guess fucking what. It has been working perfectly fine.

I do wonder, are you perhaps crippled and unable to leave your home or something that you spend all your time on here? Nobody successful in life spends all their energy arguing with random people on the internet.

The same I said to Sampei applies to you as well. Show yourself. Your physique is the most credible aspect of your knowledge. Show me what applying all that great knowledge has gotten you and I will do the same. No? I didn't think so. So keep your fucking mouth shut and stop giving advice.
Click to expand...

Above all else, you're a fucking retard.

This place takes up .01% of my time, and a more interesting intellectual exercise than the video games you play when you're not punching a clock at your shit job.

Until you "shut me up", every post I make will be a testament to how impotent and powerless you are.
 
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Ghoul said:
Above all else, you're a fucking retard.

This place takes up .01% of my time, and a more interesting intellectual exercise than the video games you play when you're not punching a clock at your shit job.

Until you "shut me up", every post I make will be a testament to how impotent and powerless you are.
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.01% of your time? You average over 20 posts every single day since you joined. Keep that bullshit to yourself.

There's no evidence for the immunogenicity claims you made. It could be said for all peptides. Post something that shows it is an issue with reta specifically. You can't because there's nothing to post. You are making shit up.

Most of the stuff we experiment with is not even approved for human use, including retatrutide. There are a million other concerns when it comes to harm reduction than dosing frequency. Are you fucking serious about this? Did you really need to write that short novel just because I said I do something differently. Both of you c.unts randomly got hostile with a stranger just because I dose it more frequently. What the fuck is the matter with you? I didn't tell anyone to follow what I do. Although now that I have tried it for 3+ weeks I have to say it's working wonderfully.

Besides there are GLPs that are dosed daily like liraglutide. That one is actually approved for human use and being marketed. They make these drugs with a longer half life because people don't want to inject frequently.

Btw, just what a thought. No photos in sight. You completely ignored that topic. There is a reason for that and you see that reason every time you look in the mirror.
 
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juicebro said:
@Ghoul
Get a life bro. My daily dosing has been working well for me. Zero sides and constant appetite suppression. Stop making dumb shit up. I am not one of those obese folks who these studies were done on. I'm a bodybuilder.

I decided on daily dosing after reading about countless people complaining about the ups and downs and guess fucking what. It has been working perfectly fine.

I do wonder, are you perhaps crippled and unable to leave your home or something that you spend all your time on here? Nobody successful in life spends all their energy arguing with random people on the internet.

The same I said to Sampei applies to you as well. Show yourself. Your physique is the most credible aspect of your knowledge. Show me what applying all that great knowledge has gotten you and I will do the same. No? I didn't think so. So keep your fucking mouth shut and stop giving advice.
Click to expand...
Like if you're a bodybuilder everything will always be fine lol
 
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Ghoul said:
Above all else, you're a fucking retard.

This place takes up .01% of my time, and a more interesting intellectual exercise than the video games you play when you're not punching a clock at your shit job.

Until you "shut me up", every post I make will be a testament to how impotent and powerless you are.
Click to expand...

juicebro said:
.01% of your time? You average over 20 posts every single day since you joined. Keep that bullshit to yourself.

There's no evidence for the immunogenicity claims you made. It could be said for all peptides. Post something that shows it is an issue with reta specifically. You can't because there's nothing to post. You are making shit up.

Most of the stuff we experiment with is not even approved for human use, including retatrutide. There are a million other concerns when it comes to harm reduction than dosing frequency. Are you fucking serious about this? Did you really need to write that short novel just because I said I do something differently. Both of you c.unts randomly got hostile with a stranger just because I dose it more frequently. What the fuck is the matter with you? I didn't tell anyone to follow what I do. Although now that I have tried it for 3+ weeks I have to say it's working wonderfully.

Besides there are GLPs that are dosed daily like liraglutide. That one is actually approved for human use and being marketed. They make these drugs with a longer half life because people don't want to inject frequently.

Btw, just what a thought. No photos in sight. You completely ignored that topic. There is a reason for that and you see that reason every time you look in the mirror.
Click to expand...
fightfightfight.gif
 
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His whole argument falls apart with liraglutide. A GLP-1 agonists that is meant to be dosed daily due to the short half life and a drug that is actually on the market. Meanwhile he is arguing about a drug that that isn't even approved. Either way there's zero evidence for what he's claiming.

Just unnecessary waste of time and energy...and rudeness. I'm out. Still waiting on those photos though. @Ghoul
Prove me wrong about what you look like. PLEASE.
 
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