It makes sense if you think every drug is like Testosterone. When all you've got is a hammer(head), everything looks like a nail.
Immunogenicity is the propensity of a protein based drug, like a peptide, to induce an unwanted anti-drug neutralizing effect, making it less effective. It's an enormous area of concern to the FDA and every single pharma peptide development process focuses on it. After demonstrating a certain drug, at a certain dose, using a certain frequency of administration, in a particular container, doesn't cause too much immunogenicity, if anything is changed, they have to prove it all over again. Once a week is the frequency that's been proven with all the GLP drugs to keep immunogenicity to a manageable level.
You can become somewhat, or even completely immune to the drug. You can become immune to the hormone it's mimicking. It may be short term, or permanent, like any other vaccine, because it's the same process going on.
So while you believe the hundreds of millions spent every year to ensure immunogenicity doesn't result in damage to health is meaningless BS, and your "bro science" method must be better, go for it.
These drugs are effective in 99% of cases for rapid, long term, weight loss, following the pharma protocols tested on thousands of subjects., yet somehow that's not good enough for you. You need a special, custom protocol dictated by your "feels". Do what the fuck you like, I'll enjoy reading about clowns like you who develop crazy metabolic disorders down the line because you stimulated your immune system into attacking your natural hormones, but try not to spread the disease of harmful practices, especially as it's for no benefit since the proven safe protocol works just fine. MESO is about HARM REDUCTION.
"Typically, repeated administration is more immunogenic than a single dose, and immunogenicity increases with more frequent dosing and longer-term treatment."
