those all-caps warnings are probably just a suggestion though… probably nothing
In all seriousness surely immunogenicity is the primary concern. I don’t think gh fibrils are amyloid. I mean better to not risk it though.
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MESO-Rx
Anabolic Steroids
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In all seriousness surely immunogenicity is the primary concern. I don’t think gh fibrils are amyloid. I mean better to not risk it though.
Some of this "generic" stuff makes me itch like hell. And it was clear. You folks are nuts injecting this man sauce.
Many times with 10x mag. Quite the exam the first few times.
Actually, some of those those monoculars go to 20x.
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bananafeet
Member
I'm not trying to stir shit, this is a serious question:
Why all the panic about rHGH peptide purity, excipients, contamination, plaque formation, immunogenicity etc
When no one gives a fuck about all the other peptides we inject? I've never seen a panic post about misfolded retatrutide or semaglutide. Is it the length of the peptide?
Or this risk profile? I'm genuinely interested.
Surely GHK-CU or MT2 could cause just as much havoc. There are reports of brain swelling from MT2 for example. Or anaphylaxis from other peptides (MOT c??).
Why all the panic about rHGH peptide purity, excipients, contamination, plaque formation, immunogenicity etc
When no one gives a fuck about all the other peptides we inject? I've never seen a panic post about misfolded retatrutide or semaglutide. Is it the length of the peptide?
Or this risk profile? I'm genuinely interested.
Surely GHK-CU or MT2 could cause just as much havoc. There are reports of brain swelling from MT2 for example. Or anaphylaxis from other peptides (MOT c??).
Ghoul
Member
You don't have to suffer in silence.
Overcome the shame, and get that itch to the clinic. You are not alone.
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Injection site infections and injuries in men who inject image- and performance-enhancing drugs: prevalence, risks factors, and healthcare seeking - Volume 143 Issue 1
I use hgh.
Gotta start somewhere. There has been plenty of talk on poorly done UG peptides. Few are paying attention. Personally, dont use the other ones. But people should wake up.
bananafeet
Member
I was not directing my comment at you. In general. I've read a fuck ton of posts on this forum and others.
You got me. Didn't look that closely, lol. 80/20. Did the spooge check.
Just my 2 cents. Understood.
For me personally, this is the only peptide that’s caused me an issue. That’s why I brought it up.
Their reta and tirz and other peptides have been fine, especially after being filtered.
For their hgh, even after being filtered in the most gentle way possible it’s coming out with aggregates/clumps/strands.
Even Brother lifter6973 on SST wants to know why there are loads in SSA GH.
Great post. Cagri another important one.
Ghoul
Member
A few points about why some peptide are of more concern than others
-The closer a peptide is to a naturally occurring protein present in the body, the greater the risk from immunogenicity. It's one thing for MT-2 to become less effective because your immune system learns to treat it as an enemy invader, it's another for you to develop antibodies to your own growth hormone or GLP potentially weakening their effectiveness for years, or forever.
-Risk is increased with exposure. Few peptides are injected daily, year after year, like rHGH. This is becoming common as the price drops.
-Most peptides aren't folded or have other "complications". They're simple strings of amino acids. In those cases purity tells you all you need to know. When there's are complication, like a folded structure that's important in the case of rHGH, or in the case of GLPs, a special lipid tail to extend its half life, these things are susceptible to going wrong and undetected by normal testing. An incorrectly manufactured tail on Tirz not only shortens half life, it can cause it to not be filtered out of your system. The correct tail attaches Tirz to albumin, for a predictable half life and clearance via the kidneys. I know of at least one example of UGL Tirz with an incorrect tail, which not only shortens how long a dose works, it can cause it to accumulate in another organ instead of being cleared, with unknown risks as it builds up over time.
bananafeet
Member
So it seems like the longer the peptide the higher the aggregation risk.
Cool I learned something today. Maybe ugl HGH is just not worth the risk. Tesamorelin maybe safer for replacement levels of treatment.
Seems like the aggregates are visible to the naked eye. So maybe a cost effective and reasonable intervention is visual inspection, and refiltering after storing for X amount of days.
bananafeet
Member
Thanks. So it's clear that SSA can really do nothing as they are a reseller not a pharmaceutical company.
It's interesting that normies are blasting these peptides "peps" that they mix with "back water" daily without any concerns
Seems like BPC/TB also have issues with aggregates as well.
As a general rule would HGH secretagogues be safer (read Tesamorelin)?
It seems like even the secretagogues have non aggregate related immunogenicity concerns.
Ghoul
Member
The visible ones aren't a huge issue.
Aggregates are only visible 100um or larger, below that size the solution will appear clear. Above 10um aggregate particles will get filtered out by the kidneys or trapped in subcutaneous tissue and not be noticed by the immune system.
The most immunogenic aggregates are between .05 um and 10um, which is the size of bacteria and what the immune system is optimized to recognize and attack. A .22um filter will eliminate the vast majority of immunogenic size aggregates (and bacteria, since many peptides aren't sterile).
bananafeet
Member
Yes but my understanding is aggregates can form after recondition and filtering. Is there a risk timeline for rHGH?
I know peptides degrade but there must be a general indication of temperature and duration of storage before it becomes too risky.
In Australia the compounding pharmacy has to affix a label saying discard after 28 days to HCG for example.
I'll try to source a good amount of 13mm .22 syringe filters and filter at least HGH going forward.
Ateam2023
Member
you can't filter that out?
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