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2 potential causes, both normal for rHGH.

1. GH and IGF-1 increase glomerular filtration rate, your kidneys filter more, more urine is produced.

This can settle down after a while as the system rebalances sodium retention.


2. GH induced high blood sugar rises above the kidney threshold, it spills into urine, glucose pulls water with it, "osmotic diuresis". A diuretic side effect from high glucose. It's why diabetics often have dry lips. This won't go away until you get your glucose under control. Reta is very effective for this.
Thanks for the response -

I've been thinking about that second point and maybe that could be the cause of my issues. Usually I'll split my GH dosed at night and fasted in the morning, and then have a large amount of high GI carb sources a few hours after. I'm on 10mg reta currently and that keep my fasted blood sugar around 75-80 and my insulin at 3-4 on 6IU's, but I have no idea how I respond after I eat.

I think I'm gonna buy a glucometer, so what should I look for? Like if I start getting those low bp symptoms like lightheadedness, and I were to take a reading, what would be the red flag zone?
 
seems like alll the issues im seeing from there hgh is from the 36iu. I think these overdosed vials are the issues. Id rather just stick to the normal 10iu vials. Ive seen no issues with those

Higher concentration = higher rates of aggregation. Literally too many molecules packed in, bumping into each other, raising the changes of sticking together. Maxing out water, 3.5ml, can reduce the problem, or get some 5ml ultra spec vials and transfer into those, adding extra water.

Opti's having cloudiness with their new 60mg in 5ml vials too. Same excess concentration cause I'm sure.
 
Thanks for the response -

I've been thinking about that second point and maybe that could be the cause of my issues. Usually I'll split my GH dosed at night and fasted in the morning, and then have a large amount of high GI carb sources a few hours after. I'm on 10mg reta currently and that keep my fasted blood sugar around 75-80 and my insulin at 3-4 on 6IU's, but I have no idea how I respond after I eat.

I think I'm gonna buy a glucometer, so what should I look for? Like if I start getting those low bp symptoms like lightheadedness, and I were to take a reading, what would be the red flag zone?

You're looking for fasted morning glucose over 100 as an indication of it being too high. That's the cleanest measurement to use. During the day, once food gets involved too many variables.
 
Sorry to jump into this conversation with a slightly off-topic question.

Given you mentioned you are using Reta, which you expect is keeping your blood glucose in check when using your HGH dose…

How does a GLP-1 such as Tirz or Reta interact? Is there a synergistic effect and an advantage in running HGH alongside?

Also, between Tirz and Reta, does one work better alongside HGH than the other, or much the same?
 
I recommend telegram. I had problems with communication with email. Also remember that China is like 14 hours ahead of us. If we message them during the day, it can be the middle of the night for them.

My friend (really my friend) took the time difference into account. He also wrote to Bella on Telegram – she replied there, but didn't answer his question. There has been no communication or response to any of his questions. Since the payment, emails can no longer be delivered, and contact is no longer good. Until the payment, contact with Bella was very good. My boyfriend is a bit worried now, as it's not normal for emails to no longer be delivered immediately after payment, and for the (previously good) contact to break off.
 
Sorry to jump into this conversation with a slightly off-topic question.

Given you mentioned you are using Reta, which you expect is keeping your blood glucose in check when using your HGH dose…

How does a GLP-1 such as Tirz or Reta interact? Is there a synergistic effect and an advantage in running HGH alongside?

Also, between Tirz and Reta, does one work better alongside HGH than the other, or much the same?

All GLPs help offset the insulin resistance caused by GH.

When cells are exposed to long periods of high levels of insulin, which is produced to signal them to absorb extra glucose from blood, they respond by downregulating insulin receptor sensitivity, creating insulin resistance. They don't respond as well to the insulin signal, glucose in blood stays high.

GLPs make insulin producing cells function better. This means a quicker response to glucose spikes. Cells throughout the body are exposed to less "high insulin time". Over time., insulin receptors become more sensitive, and just a little insulin makes them pull glucose out of the blood fast, keeping glucose levels in check.

Reta is often preferred by BBs because the dose that gives this benefit doesn't cause much appetite suppression. Sema and Tirz provide the same benefit, but can come with appetite suppression that may be unwanted if you're not trying to lose weight.
 
All GLPs help offset the insulin resistance caused by GH.

When cells are exposed to long periods of high levels of insulin, which is produced to signal them to absorb extra glucose from blood, they respond by downregulating insulin receptor sensitivity, creating insulin resistance. They don't respond as well to the insulin signal, glucose in blood stays high.

GLPs make insulin producing cells function better. This means a quicker response to glucose spikes. Cells throughout the body are exposed to less "high insulin time". Over time., insulin receptors become more sensitive, and just a little insulin makes them pull glucose out of the blood fast, keeping glucose levels in check.

Reta is often preferred by BBs because the dose that gives this benefit doesn't cause much appetite suppression. Sema and Tirz provide the same benefit, but can come with appetite suppression that may be unwanted if you're not trying to lose weight.
Nice once thanks for this.

With this in mind, can serum IGF-1 blood levels be blunted when using HGH alongside a GLP-1?
 
I've noticed the Anavar, Dbol, Winstrol, pretty much all oral steroids are out of stock for a while. Have they said what the issue is, and when the ETA is for these to be back in stock?
 
My friend (really my friend) took the time difference into account. He also wrote to Bella on Telegram – she replied there, but didn't answer his question. There has been no communication or response to any of his questions. Since the payment, emails can no longer be delivered, and contact is no longer good. Until the payment, contact with Bella was very good. My boyfriend is a bit worried now, as it's not normal for emails to no longer be delivered immediately after payment, and for the (previously good) contact to break off.
My reship arrived within a week of issuing. Bella was my rep and she took care of it pretty quickly.

But prior to that, it was a mission getting an answer. Ive ordered from different sources so I wasn't too concerned about the length of waiting but rather she couldn't actually give me a straight answer about asking the shipping company if they had any idea of it being seized by customs or if it was lost. The label was created for the original package but no waybill ever popped up. No waybill= never shipped. So after weeks of hassling she finally organised a reship and it arrived within a week. I still have no idea where the original package is or if it was even shipped. But I got all my stuff in the end.
 
Just google it bruh.


Bioglutide is gonna be a game changer here. It's oral (small molecule, not a peptide) and has activity at GLP-1, GIP, GCG, and IGF-1.
I have the impression that the more receptors are targeted, the less effective the action is on each individual receptor.
However, it also seems that it is not less potent than Tirz or Sema.
 
I have the impression that the more receptors are targeted, the less effective the action is on each individual receptor.
On the surface of your statement, this is untrue (see chart of effect at each receptor site). But it could be true on a 1:1 molecule to receptor interaction, in which case you'd have to calculate moles per milligram.
 

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On the surface of your statement, this is untrue (see chart of effect at each receptor site). But it could be true on a 1:1 molecule to receptor interaction, in which case you'd have to calculate moles per milligram.

It's true in the sense that GLPs like Tirz, and Reta artificially limit their protein chains to under 40 amino acids. (both 39).

In order to "fit" glucagon agonism into the same 39 amino size chain as Tirz, some potency had to be sacrificed on GLP.

It's done because over 40 aminos becomes a "biologic" class drug, with much stricter FDA regulation and less protection from competition.
 
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