Great info. Have you tried VersaPenn base? They state it’s a great candidate for HRT.
They also have different bases on their site for other drugs
Elegant Transdermal Topical for HRT Formulated with Hyaluronic Acid and Concentrated Phosphatidylcholine VersaPenn™ Anhydrous Lipid (AL) Cream Base is a proprietary topical formulation specific only to SpecializedRx. Formulated with highly concentrated natural sunflower phospholipids and other...
specializedrx.com
Thank you JoeySmith. I haven’t used or heard of this base before. It looks very interesting. I read where VersaPenn promotes enhanced bioavailability through a unique nanocarrier liposome system in the following link…
***CONTACT YOUR SALES REP FOR PRICING AND AVAILABILITY*** ***SPECIALIZED RX PRODUCTS ARE DROP-SHIPPED FROM CIRCLE PINES, MN***
pharmasd.com
….but it’s my understanding that ethosomes have greater bioavailability than liposomes. This is a topic that fascinates me and I’m looking forward to delving into this deeper next year when I have more time. These liposomal and ethosomal bases don’t look that difficult to make with a homogenizer or sonicator and ChatCBT has certainly opened up this topic with lots of details in terms of formulas and detailed procedures.
I don’t know which base is the best or how much difference there really is between these bases, but I can say from my own personal experience that PhloJel Ultra definitely works great. Dr Keith Nichols of Tier One Health uses HRT base for all his patients and he swears by it. I think PhloJel Ultra is also a liposome base like VersaPenn.
One of my brother-in-laws was using Atrevis Hydrogel until I started making him a 20% cream using VaniCream (found on Amazon) as the base and he says he feels just as good on it if not better than he did on Atrevis Hydrogel. The first base he tried from the pharmacy was gritty (poorly navigated and definitely not homogenized) and his total T was only in the low 500’s. When he tried a new pharmacy that used Atrevis Hydrojel, his total T went into the 800’s, but I’m sure he’s not applying it as good as he could in terms of probably not cleaning his skin as good as he should before use and not applying it the best areas. He still hasn’t done labs with the VaniCream homebrew I made him, so there’s no data on that except for him telling me he feels at least as good as he does on the Atrevis Hydrojel.
All I have so far is my own personal labs on PhloJel Ultra and the fact that I feel just as good on my homebrew cream than I did on 200+ mg weekly cyp. In fact, I had to inject 400+ mg weekly of Cyp to get the kind of lab results I’m getting on my homebrew cream. Now that my injection frequency is down to only one weekly Deca injection, my CRP has also come down.
I hope in time we can get good hard data on these different bases to see just how well they work, but I plan to have a good homebrew Ethosome base to share sometime next year with ingredients and procedures.
This is a really good read below….
Skin diseases are a common health problem affecting millions of people worldwide. Effective treatment often depends on the precise delivery of drugs to the affected areas. One promising approach is currently the transdermal drug delivery system (TDDS), whose significant challenge is the poor...
www.mdpi.com
“The primary difference between liposomes and ethosomes lies in their composition and structure. While both systems consist of phospholipid vesicles, ethosomes are unique due to the presence of ethanol in their formulation, which significantly enhances their deformability and penetration capabilities. Liposomes, composed mainly of phospholipids and cholesterol, are more rigid, limiting their ability to traverse the stratum corneum. Ethosomes, in contrast, are highly elastic and can more easily penetrate the skin through paracellular pathways, thanks to the fluidizing effect of ethanol on lipid bilayers. In terms of skin penetration, ethosomes outperform liposomes. Traditional liposomes struggle with slow penetration rates due to their rigidity, whereas ethosomes, with their higher deformability, achieve more efficient penetration through the skin layers, enabling enhanced drug delivery [
24]. Furthermore, while liposomes can be administered via oral, parenteral, topical, and transdermal routes, ethosomes are primarily used for topical and transdermal applications, particularly when deeper skin penetration is required. Products such as Ambisome, DaunoXome, and Doxil are liposome-based therapies, while ethosome-based products like Nanominox and Cellutight EF have shown their effectiveness in transdermal applications. Moreover, the size and structure of the vesicles also influence their function. Liposomes, which range from 0.01 to 1 µm in size, are categorized based on the number of bilayers and vesicle diameter, which affects their circulation time and drug encapsulation efficiency. In contrast, ethosomes, which range from 0.01 µm to a few microns, penetrate skin layers more rapidly and exhibit higher transdermal flow rates, making them more effective for topical and transdermal drug delivery applications [
27].”
