Skin penetration base

[Ghoul]

Anyone had objectively good results with any of the premade skin penetrating bases for making topicals? This has been discussed, but not much in the way of success stories.

Unexpectedly found a cure for a longstanding, rare, "uncurable", skin condition. There are literally less than 1000 people worldwide using this recently discovered miracle drug, ingredients are dirt cheap, but the speciality compounding pharma that fills the prescription won't tell me what base is being used. Happy to buy it premade, but want to ensure I can make it if needed,

Figured I'd rather check here first than the homemade cosmetics people.

 

[sinistral]

Where is goingstronger when you need him?

 

[rockyraccoon]

Anyone had objectively good results with any of the premade skin penetrating bases for making topicals? This has been discussed, but not much in the way of success stories.

Unexpectedly found a cure for a longstanding, rare, "uncurable", skin condition. There are literally less than 1000 people worldwide using this recently discovered miracle drug, ingredients are dirt cheap, but the speciality compounding pharma that fills the prescription won't tell me what base is being used. Happy to buy it premade, but want to ensure I can make it if needed,

Figured I'd rather check here first than the homemade cosmetics people.

US4296104A - Therapeutic dimethyl sulfoxide composition and methods of use - Google Patents

The use of urea and/or ethanol with pharmaceutical compositions containing DMSO is disclosed. The result is a reduction in the undesirable side-effects normally associated with the application of DMSO compositions, enhancement of the desired physiological effects produced by DMSO compositions...

patents.google.com

 

[qadsan]

PhloJel Ultra works well. Pentravan is another good choice (might be better than PhloJel), and HRT base is also a very good choice. Atrevis Hydrogel is another, but I believe it’s alcohol based.

I was in the process of experimenting with making my own episomal bases for transdermal drug delivery and invested in a good roto-stator homogenizer as well as a sonicator and was starting to buy ingredients, but unfortunately some things have come up that I need to deal with and I won’t be able to get back to this until early next year.

In any case, I can tell you that simply using PhloJel Ultra and manually making a 20% strength testosterone cream with a spatula and slab produced a cream that brought my total T level to 1,819 and free T to 362.4 simply using 1ml of cream applied daily from a topi-click dispenser. I’m sure the homogenizer and sonicator will yield even better results once I get the particle size down and I’m looking forward to making my own base, and someday having the average particle size checked.

I’ve done injections via homebrew for the last 15+ years, so transdermals are fairly new to me, but I’m blown away by these numbers and I feel great on the cream. I’ve dialed this down a bit and plan to do labs again in another month or so, but transdermals work.

Also, I’ve made test cream using Vanicream asa base which can be found on Amazon, as well as Neutragena Hydroboost and they apparently also work because the guys I’ve made it for are very happy with it. I have no idea how it compares to PhloJel Ultra in terms of bioavailability of the drug, but one day these guys will get some labs done and I’ll know more.

In any case, these bases work for transdermal delivery of test, then they’ll likely work for other drugs too.

 

[Ghoul]

PhloJel Ultra works well. Pentravan is another good choice (might be better than PhloJel), and HRT base is also a very good choice. Atrevis Hydrogel is another, but I believe it’s alcohol based.

I was in the process of experimenting with making my own episomal bases for transdermal drug delivery and invested in a good roto-stator homogenizer as well as a sonicator and was starting to buy ingredients, but unfortunately some things have come up that I need to deal with and I won’t be able to get back to this until early next year.

In any case, I can tell you that simply using PhloJel Ultra and manually making a 20% strength testosterone cream with a spatula and slab produced a cream that brought my total T level to 1,819 and free T to 362.4 simply using 1ml of cream applied daily from a topi-click dispenser. I’m sure the homogenizer and sonicator will yield even better results once I get the particle size down and I’m looking forward to making my own base, and someday having the average particle size checked.

I’ve done injections via homebrew for the last 15+ years, so transdermals are fairly new to me, but I’m blown away by these numbers and I feel great on the cream. I’ve dialed this down a bit and plan to do labs again in another month or so, but transdermals work.

Also, I’ve made test cream using Vanicream asa base which can be found on Amazon, as well as Neutragena Hydroboost and they apparently also work because the guys I’ve made it for are very happy with it. I have no idea how it compares to PhloJel Ultra in terms of bioavailability of the drug, but one day these guys will get some labs done and I’ll know more.

In any case, these bases work for transdermal delivery of test, then they’ll likely work for other drugs too.

Terrific man, this is just what I was looking for. Need a base for a 2% statin (lovastatin) and 2% cholesterol mix, hopefully this'll work.