The War on Opioids - Time for Re-Evaluation..?

While you're waiting for the hard copy version, here are a few interesting items cited in the book:

Colbert Links Big Pharma's Sackler Family To America's Opioid Crisis


View: https://www.youtube.com/watch?v=_cJ_lyeH7Os

To those who haven't followed the story closely in the news and want to maintain the suspense of the book's narrative, the following provides a lot of spoilers, so maybe don't watch:

Opioids III: The Sacklers: Last Week Tonight with John Oliver (HBO)​



View: https://www.youtube.com/watch?v=uaCaIhfETsM

Sackler Gallery

https://sacklergallery.com/
View attachment 175923

The first excellent video, made me think about many things. I didn't watch the second one, I'm waiting for the book :)
 
Nicely-written book!

I think it should be firstly noted that obviously this is what happens when you operate a business and don't pay the right people enough money.

You know I am going to venture the hole you have placed before me... o_O And I have no doubt that if you said he wrote the book well that he did so. Sounds like it's worthy of some interpretation... :p

Here are the EDITORIAL REVIEWS published on Amazon at their online point of sale....:


Editorial Reviews

Review

New York Times Book Review 100 Notable Books of the Year • One of The Washington Post's 10 Best Books of the Year • TIME Magazine 100 Must Read Books of 2021 • One the Best Books of the Year: NPR, Slate, EW, Boston Globe, Goodreads, The Guardian, Town & Country, BuzzFeed, LitHub, Vulture, and more • Winner of the Baillie Gifford Prize for Non-Fiction • One of President Obama's Favorite Books of the Year

These reviews begin with 2 of the biggest liberal lying corruptors of this republic, find further praise from anyone in between looking to be on the scene, and conclude with the devil behind this travesty himself, and none other than the president who ordered his drug czar to cause all of this chimes in after having his staff make him some cliff notes. lol. THIS IS - WHERE WE HAVE FALLEN TO.... And FYI the AUTHOR works for the first Press listed... And the Washington post exchanges hand jobs with them regularly...

“I read everything he writes. Every time he writes a book, I read it. Every time he writes an article, I read it … he’s a national treasure.” - Rachel Maddow, host of MSNBC’s “The Rachel Maddow Show” and author of the #1 New York Times bestselling Blowout

A review by a truly hideous scripted monster...

“An engrossing (and frequently enraging) tale of striving, secrecy and self-delusion….Keefe nimbly guides us through the thicket of family intrigues and betrayals… Even when detailing the most sordid episodes, Keefe’s narrative voice is calm and admirably restrained, allowing his prodigious reporting to speak for itself. His portrait of the family is all the more damning for its stark lucidity.” - Jennifer Szalai, The New York Times

Sounds like an episode of DALLAS from the 1980's. GOTZ TO BE GUUD... Its sure sounds like Keefe must have been right there for it all...!

“A true tragedy in multiple acts. It is the story of a family that lost its moorings and its morals… Written with novelistic family-dynasty and family-dynamic sweep, EMPIRE OF PAIN is a pharmaceutical FORSYTHE SAGA, a book that in its way is addictive, with a page-turning forward momentum.” - David M. Shribman, The Boston Globe

I'm starting to see a theme. Perhaps if the Sacklers opened a breakfast food franchise we could never stop and then sue them for bacon addiction?

“A brutal, multigenerational treatment of the Sackler family… Keefe deepens the narrative by tracing the family's ambitions and ruthless methods back to the founding patriarch, Arthur Sackler…His life might be a model for the American dream, if it hadn't arguably laid the foundations for a still-unfolding national tragedy.” - Brian Mann, NPR.org

VERY TRUE. An unfolding tragedy that could have easily been averted had anyone with a brain approached the problem realistically and with the slightest degree of care. One could almost say the abruptness and ill-conceived method by which they removed an entire TYPE (All Opioids) of medication to which THEY KNEW could not be ceased immediacy is complicity within itself...! The SHEER MAGNITUDE of this situation has been escalated to uncontrollable activity which would not otherwise have been incurred. Due to the ignorant actions of the powers that be, we may have been pushed to a point of no return. UNQUESTIONABLY, the stakes and danger was increased 10 fold by this abrupt discontinuation of opioids. ARE YOUR KIDS SAFER NOW.?? Now that nothing is genuine? FYI - Kids never gave one bloody shit about an opioid... But what could be in their Wheaties now...? Hmmm...

“The opioid epidemic has killed nearly half a million Americans over the past two decades. Many of their loved ones, along with public health advocates and experts, believe that one very rich, very famous family has never fully faced the consequences for its role in those deaths. EMPIRE OF PAIN, the explosive new book by journalist Patrick Radden Keefe, is an attempt to change that — to hold the family accountable in a way that nobody has quite done before, by telling its story as the saga of a dynasty driven by arrogance, avarice and indifference to mass suffering…. Keefe marshals a large pile of evidence and deploys it with prosecutorial precision. Keefe is a gifted storyteller who excels at capturing personalities.” - Jonathan Cohn, The Washington Post

I am actually going to give Cohn a well deserved A+ on his witty and intelligent use of the English Language here. Cohn is just reciting Keefe for the most part here so we'll give him a hare of credit for being a smarty-pants. Cohn DID go to the trouble to quote keefe's ignorance. - - "nearly half a million Americans killed over the past two decades", OVER HALF OF THAT HAS BEEN IN THE LAST 3 YEARS - AND FYI -that's three years after the gov cut the drugs off and the number is only rising...

"Empire of Pain reads like a real-life thriller, a page-turner, a deeply shocking dissection of avarice and calculated callousness… It is the measure of great and fearless investigative writing that it achieves retribution where the law could not….Exhaustively researched and written with grace and gravity, Empire of Pain unpeels a most terrible American scandal. You feel almost guilty for enjoying it so much." - The Times (London)

Funny how real pain in a Roman Society which should have a Roman counter measure is portrayed to be so incorrect. But of course STEROIDS have no place in gladiator type sports either... Right?? Still, it appears OK to experience glee and excitement from a good tale. No matter the "gravity". But lets be sure and NOT confuse "grace" with INTEGRITY...

"Keefe has a way of making the inaccessible incredibly digestible, of morphing complex stories into page-turning thrillers, and he's done it again with Empire of Pain…A scathing — but meticulously reported — takedown of the extended family behind OxyContin, widely believed to be at the root cause of our nation's opioid crisis. It's equal parts juicy society gossip and historical record of how they built their dynasty and eventually pushed Oxy onto the market.” - Seija Rankin, Entertainment Weekly

"The ROOT of our nations opioid crisis"... First lets qualify "opioids". Next lets back up a step or two.. Please..

“An air-tight indictment of the family behind the opioid crisis….[an] impressive exposé.” - Harriet Ryan, The Los Angeles Times

Marsha is that you?!? NOPE... It FIRST takes CUSTOMERS to abuse them. Then it takes doctors to prescribe them. And lets not forget the pharmacies the sell them. But hey I do find a tad bit of culpability in that last review, SO maybe we can blame it on the drug reps that spread legs in docs offices on a daily basis (and in between patients).... Lets not forget their interests and why individuals $WORK$... But I don't recall Oxycontins ever handed out in docs offices like peanuts or PAXIL...

“A damning portrait of the Sacklers, the billionaire clan behind the OxyContin epidemic. If you are someone who engages in this kind of sneaky conduct, the last person you want reporting on you is Keefe….[He] has a knack for crafting lucid, readable descriptions of the sort of arcane business arrangements the Sacklers favored. He is also indefatigable….The Sackler infighting described in Empire of Pain will surely prompt many comparisons to the HBO series Succession.” - Laura Miller, Slate

We could also consider that Oxycodone has been around forever. I'm not sure exactly how you make the leap from taking a time tested pain reliever, combining another agent to slow and control the release TO HELP PREVENT ABUSE, and helping folks in pain from suffering. To be so outlandish. BUT LETS BE SURE AND UNDERSTAND THAT THE OXYCODONE MOLUCULE WAS IN NO WAY INVENTED BY THE SACKLER FAMILY.. But hey they did make it TIME RELEASE hence "Oxy-CONTIN" (as in continuous release). But go ahead and give them credit for a drug that has probably been around a century...

"One of the Ten Best Books of 2021"
– Laura Miller, Slate


CHIRP CHIRP LITTLE PARROT....

“Put simply, this book will make your blood boil….a devastating portrait of a family consumed by greed and unwilling to take the slightest responsibility or show the least sympathy for what it wrought….a highly readable and disturbing narrative.” - John Carreyrou, The New York Times Book Review (cover)

I bet it will....... IF YOU ARE LACKING A BRAIN TO THINK WITH.....

“A shocking saga… [a]tour-de-force account… [Keefe] brings to life the obsessive personalities and ferocious energy of some members…The Sacklers emerge as a shameless bunch, but Empire of Pain also poses troubling questions about the US healthcare system that permitted them to flourish.” - John Gapper, The Financial Times

Good Review by a man that is probably pretty familiar with the US and WORLD CORPORATE GREED destroying us on all levels today...

“Rigorously reported and brilliantly executed Empire of Pain hones in on the family whose company developed, unleashed, and pushed the drug on Americans, pulling in billions of dollars for themselves in the process….This is an important, necessary book.” - Hillary Kelly, New York magazine

Worthless review by an envious stooge minion....

"Indefatigable investigative journalist Keefe crafts a page-turning corporate biography and jaw-dropping condemnation of the Sacklers’ amoral disregard for anything save the acquisition of power, privilege, and influence. In Keefe’s expert hands, the Sackler family saga becomes an enraging exposé of what happens when utter devotion to the accumulation of wealth is paired with an unscrupulous disregard for human health." - Carol Haggas, Booklist

Free will is a bitch and Free lunch don't exist. The best part is that I got good money that the same people turning on Purdue now are the same ones that once praised and encouraged an TOOK MONEY FROM THEM minimally in the form of RETURNS ON CAPITOL INVESTMENT....

“An engrossing and deeply reported book about the Sackler family, the owners of Purdue Pharma. Their company created Oxycontin, the opioid introduced in the mid-90s that sent a wave of addiction and death across the country. Unlike previous books on the epidemic, Empire of Pain is focused on the wildly rich, ambitious and cutthroat family that built its empire first on medical advertising and later on painkillers. In his hands, their story becomes a great American morality tale about unvarnished greed dressed in ostentatious philanthropy.” - Time Magazine, The Best Books of 2021 So Far

MY TAKE IT IS PRE-MATURE PRIOR TO REVIEW OF THE BOOK. I did that on purpose. I'TS BEEN SO LONG SINCE I HAVE TASTED CROW THAT I CAN'T HELP MYSELF. HELL, ALL FRIED UP, BUFFALO SAUCE, AND SOME RANCH DRESSING. WHO KNOWS...

1. But lets not confuse OXYCODONE and HYDROCODONE.
2. Lets not let it go unnoticed that hydrocodone was the critical victim and not directly related.
3. Lets not forget how many studies there have been that prove hydrocodone has a very short wean time and proven NOT physically addictive.
4. We must ask WHY hydrocodone was punished as a leading man in a play redone by many. The banning of opioids has been nothing but the vehicle to this onslaught of deadly fentanyl, opioid analogs even more powerful, the gateway opening to all kinds of new illegal drug production, and MOST IMPORTANTLY the inception of the drug DEMAND and DISTRIBUTION CHANNELS all ALL TIME HEIGHTS that may never be undone.
5. WHY ON GOD'S GREEN EARTH A SUDDEN AND ABRUPT CUT OFF BY THE SAME PEOPLE THE SHOULD KNOW THEY CAN'T DO THAT. So does the DEA even have a single doc on staff ?? or are they just running around playing doctor indeed... The last time I checked practicing medicine without a license is a crime. Just sayin..

Over 100K people have died from opioids over the past three years this one will far surpass the last TWO YEARS. Other illegal drugs including cocaine and amphetamine are quickly finding their ways into lives of people that would not otherwise have gone there. ICE, Krokodil, Spice, other far our exotics. LASTLY BUT FAR FROM LEAST LETS NOT FORGET THE ONSLAUGHT OF DEATHS COMING DOWN THE PIPE FROM ALCOHOL ABUSE now the nation's leading pain self-medication... And only new opioid agonizing drugs hit the streets every day and way more damaging and addictive I hear... YES I am an anecdotal layman. PLEASE CHALLENGE ME...

About the Author (He serves his masters as do we all)

Patrick Radden Keefe is a staff writer at The New Yorker and the author, most recently, of the New York Times bestseller Say Nothing: A True Story of Murder and Memory in Northern Ireland, which received the National Book Critics Circle Award for Nonfiction, was selected as one of the ten best books of 2019 by The New York Times Book Review, The Washington Post, the Chicago Tribune and The Wall Street Journal, and was named one of the “10 Best Nonfiction Books of the Decade” by Entertainment Weekly. His previous books are The Snakehead and Chatter. His work has been recognized with a Guggenheim Fellowship, the National Magazine Award for Feature Writing and the Orwell Prize for Political Writing. He is also the creator and host of the eight-part podcast Wind of Change.

So. @Mr. Keefe. WHO really is to blame. WHAT is the intended outcome of measures to date. WAS this truly an intent to fix a problem, or more like an attempt to expedite an ugly end for those involved that backfired on the world.... DO YOU EVEN HAVE A CLUE THE TRUE NET RESULT TALLY NOT EVEN BEGUN YET....!!
 
I am not posting any new articles here today. But I just wanted to point out some recent observation in publicized reads as well as personal experience. As we have seen a couple of hints over the past year that the powers that be are starting to become aware of the depth of this error in judgement - in terms of the carte blanche opioid cut off, and probably in deep regret that they rescheduled hydrocodone to get it included... BUT - What I am observing and acknowledging is that the LEGAL WHEEL OF CIVIL LITIGATION has now achieved a point of precedence that is sealing this door shut as is. A point of no return so it would seem...

I recently also noted that even dental offices are now under siege as well on the opioid prescriptions. I had interpreted that they were the last frontier in getting a decent opioid script, and rightfully so if you know tooth nerve pain... But it appears main stream medical is shutdown so hard that these powers that be now have the luxury and ability to extend their swath on further.

I have even been advised of interpersonal experiences with acquaintances where doctors offices are actually ADMINISTERING A SINGLE DOSE OR ORAL OPIOID in the course of their practice in a given procedure. I mean like - "OK" we are going to hurt you pretty good today in this procedure, but never fear, I am going to dose with with this unbelievably mitigating SINGLE TABLET of hydrocone and tylenol combined and send you on your way and you will be fine.." This is REALLY HAPPENING. And I find incredible amuzement in the POINT that the whole reason "Pill Mills" were attacked was predicated on the premise that it was wrong to practice medicine in the same office by which opioids are prescribed pharmacologically. If that is not a mind bender I don't know what is... Got a gangrenous gall bladder to remove,???, hey don't fret, we will send you home with a script of 5/500 fydros TWELVE COUNT. And as we piss our pants even for writing that much 20 times in a month of normal operation. Just..... !!! ... !!!!

Yet illegal opioids like fentanyl and worse continue to increase their infiltration into the US black markets, and appear to be increasing in the cross-over contamination of other street products. I mean how long is it before kids are thinking they are getting stoned on weed and passing out like a normal weed buzz, and then only to be found dead the next day, as no one could have been the wiser. REALLY!!!!!!

Everything that has happened in this whole drug control PHANTASM has been ill-conceived and poorly employed THERE IS NO DOUBT... You honestly can't help but wonder if it was intentional... As with all this "wisdom" making these calls and incredible life changing regulations, How could they have POSSIBLY been so sloppy. And as opioid related drug deaths and overdoses have only risen incredibly since this all began. And yet no one will admit they made a mistake. When will they figure out that this freight train is out of control and that the window to stop it in time is closing fast...

DO NOT COOK your vascular system with NSAIDs and become a victim of the coming COUMADIN APOCOLYPSE... That is if you make it that long without bleeding out from an upper GI ulcer. And forget about the GUT DAMAGE to that system that is proving to be one of the most influential organs in the body possibly having the highest level on direct control over brain activity. No nothing to see there...

So drink yourself to death and fricassee your livers seems to be the optimal viable option. Heavens wait till that bill comes in. All along rehab systems are trying to portrait alcohol as a dopamine actor and even integrate opioid management mitigation systems as a viable treatment. And when alcohol has got JACK SHIT to do with DOPAMINE. Its a fucking anesthetic...

It would almost appear as if the powers that be are willing to pay a much higher price in order to cause more harm than good. Just sayin...:confused:
 
And I am gong to take this opportunity to plug this once more.... As common sense appears to have left the building. All the hype about people using opioids to "feel good or pleasure".. Well as it turns out the studies are in, and its as solid as an oldschooler advising that testosterone does not work if yer fat...

Survey Sayz.... PLEASURE JUST MIGHT BE THE ANTIDOTE FOR PAIN.... But what do I know...
 
I am not posting any new articles here today. But I just wanted to point out some recent observation in publicized reads as well as personal experience. As we have seen a couple of hints over the past year that the powers that be are starting to become aware of the depth of this error in judgement - in terms of the carte blanche opioid cut off, and probably in deep regret that they rescheduled hydrocodone to get it included... BUT - What I am observing and acknowledging is that the LEGAL WHEEL OF CIVIL LITIGATION has now achieved a point of precedence that is sealing this door shut as is. A point of no return so it would seem...

I recently also noted that even dental offices are now under siege as well on the opioid prescriptions. I had interpreted that they were the last frontier in getting a decent opioid script, and rightfully so if you know tooth nerve pain... But it appears main stream medical is shutdown so hard that these powers that be now have the luxury and ability to extend their swath on further.

I have even been advised of interpersonal experiences with acquaintances where doctors offices are actually ADMINISTERING A SINGLE DOSE OR ORAL OPIOID in the course of their practice in a given procedure. I mean like - "OK" we are going to hurt you pretty good today in this procedure, but never fear, I am going to dose with with this unbelievably mitigating SINGLE TABLET of hydrocone and tylenol combined and send you on your way and you will be fine.." This is REALLY HAPPENING. And I find incredible amuzement in the POINT that the whole reason "Pill Mills" were attacked was predicated on the premise that it was wrong to practice medicine in the same office by which opioids are prescribed pharmacologically. If that is not a mind bender I don't know what is... Got a gangrenous gall bladder to remove,???, hey don't fret, we will send you home with a script of 5/500 fydros TWELVE COUNT. And as we piss our pants even for writing that much 20 times in a month of normal operation. Just..... !!! ... !!!!

Yet illegal opioids like fentanyl and worse continue to increase their infiltration into the US black markets, and appear to be increasing in the cross-over contamination of other street products. I mean how long is it before kids are thinking they are getting stoned on weed and passing out like a normal weed buzz, and then only to be found dead the next day, as no one could have been the wiser. REALLY!!!!!!

Everything that has happened in this whole drug control PHANTASM has been ill-conceived and poorly employed THERE IS NO DOUBT... You honestly can't help but wonder if it was intentional... As with all this "wisdom" making these calls and incredible life changing regulations, How could they have POSSIBLY been so sloppy. And as opioid related drug deaths and overdoses have only risen incredibly since this all began. And yet no one will admit they made a mistake. When will they figure out that this freight train is out of control and that the window to stop it in time is closing fast...

DO NOT COOK your vascular system with NSAIDs and become a victim of the coming COUMADIN APOCOLYPSE... That is if you make it that long without bleeding out from an upper GI ulcer. And forget about the GUT DAMAGE to that system that is proving to be one of the most influential organs in the body possibly having the highest level on direct control over brain activity. No nothing to see there...

So drink yourself to death and fricassee your livers seems to be the optimal viable option. Heavens wait till that bill comes in. All along rehab systems are trying to portrait alcohol as a dopamine actor and even integrate opioid management mitigation systems as a viable treatment. And when alcohol has got JACK SHIT to do with DOPAMINE. Its a fucking anesthetic...

It would almost appear as if the powers that be are willing to pay a much higher price in order to cause more harm than good. Just sayin...:confused:
Thats why europe isnt having this problem, you can get oxy 20,40,80 so easy, and there heroin has no fent in it. Only in america is this fentynal going rampet. Other countries have, codeine, etc, dilaudid in canada is readily available.

CVS no longer administers promethazine with codeine, even if you have a prescription. They stopped completely.
 
The first excellent video, made me think about many things. I didn't watch the second one, I'm waiting for the book :)
Also I think I forgot to comment on this earlier...

Personally I think you should think a little deeper, understand the various forms of opioids used medicinally, what their real mechanisms and actions are, the conditions that merit, and most importantly the political power grab here so strong that it is the BEGINNING OF THE STRIPPING OF POWER FROM MEDICAL PROFESSIONALS as they now walk around in a terrified daze reciting they feel like they are taking crazy pillz.. DO NOT think this is not a gateway to further controls of YOUR PHYSICIANS MORAL CODE AND BIAS IN HIS PROFESSIONAL DECISION MAKING PROCESS IN ALL CONSTRUCTS.!!!!! And @Millard (Respectfully and ya know I luv ya!!)

As far as Colbert is concerned, the only think he can draw links to without a script to read is his hand-to-prick. An obvious beta orbiter cuck that likes to steal sloppy seconds.

As for John Oliver - ANYTHING FOR A BUCK. And hey the British Accent Sells bigtime in the US always. Shit at least half of the success of the STAR WARS Movie franchise was derived from that accent. But grab your money while you can if that accent is even legit...

As for as the Press Pics of the Corporate Photos of the Sackler biz. Do they look any different than any other corporate leaders in the US? Really? They are HUMAN right? The correct answer is POW!,, As a FAMILY you just set and one of the biggest examples of the American Dream now embossed IN PLATINUM for all time to come..!!!! I wonder what the managing directors of Monsanto, 3M, and any other big hot topic business leaders look like. Maybe I will post them and we can do a comparison.. But please don't post Sackler pics presenting them vicariously as "Mug shots" unfairly. The only thing they are guilty of is SUCCESS.

The only difference IF YOU LISTEN, is that the Sacklers are highlighted as a "FAMILY". And the only thing tells us is that unlike their competitors, they succeeded THEMSELVES and WITHIN. Which tells me they did not play bt standard rules of engagement and ignored the BASIC LAWS OF LUBRICATION....:oops:

So call me a devils advocate on this one and that sits fine with me..
 
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Thats why europe isnt having this problem, you can get oxy 20,40,80 so easy, and there heroin has no fent in it. Only in america is this fentynal going rampet. Other countries have, codeine, etc, dilaudid in canada is readily available.

CVS no longer administers promethazine with codeine, even if you have a prescription. They stopped completely.
HERE HERE - AND THE CROWD GOES WILD..>!!!!!!!!!

But hey the US supposedly consumed the largest amount of opioids in the world market bar none. Conveniently they failed to make the correlation that the US has a COINCIDENTAL RELATIONAL SUCCESS RECORD of being the most successful country in the history of the world... And in less than 500 years as an empire FROM SCRATCH... Additionally if you look at the history of the American business model in the exponentiating time line in which it boomed. That happened to precisely correlate with the inception and availability of opioid as a pain analgesic. How else you think all them old snappers stayed at it till such a ripe old age.!?!?!?!?

I won't even pose to tangent the possibility of what this also may say on what the powers that be KNOW about where the US market is heading..

Thats an interesting note on Canada and Dilaudid. And while that drug premises as the almighty non-tolerable consistenly effective pain killer used in hospitals and extreme pain situations.. The average person fails to realize that Dilaudid has a 25% efficacy when take orally and is in essence a glorified hydrocone. EITHER ONE HAS A DOCUMENTED 5 DAY PHYSICAL WITHDRAWAL PERIOD. B... T... W....

It's Miller Time... All hail the almighty bionic liver... LOL
 
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CLEARLY THEY ARE NOT GOING TO STOP until we are all dead or dehumanized....

Hmm so then they are going to start using hypnosis as anesthesia during surgical procedures I guess huh...?!? !
Hahaha that apparently can be quite effective. They will just use other drugs to anaesthetise you.
 
Hahaha that apparently can be quite effective. They will just use other drugs to anaesthetise you.
I dont think its possible. If you take a look at the practice an anesthesiology, they already use a "Cocktail" of MULTIPLE AVENUES to keep you down in surgeries. Especially extended ones. THE Opioid MU receptor is the primary effective target for pain. I was actually shocked to see the RN Anesthetist shoot and entire 20 or 30 ml jug of Propofol into me just for a colonoscopy recently. No shit he just fired it all in there at once. I mean are there different strengths of that stuff,?!? because once having wires taken off my jowls they were administering it on a "click basis"....

BUT YOU ACTUALLY TAUGHT ME SOMETHING HERE TODAY, As I always assumed propofol was an MU Agonist. I was surprised not only is it not but its just a serious RELAXOR/"sleep drug". You hear about the folks paralyzed from time to time and feeling some shit but cant scream. Starting to make sense.

Strangely I note in my reads that Propofol is NOT even an analgesic..

I did some some serious dreaming during the 15 mins I was down. I was like I didn't think you dreamt on this stuff. he was like OH YEAH... I'm starting to understand Michael Jackson's fixation with the stuff... Hell I think me recent research revealed its not even that heavily controlled as a substance.. However just not mainstream available...

I was surprised to read that Propofol is NOT reversible via antidote so It must have a really high LD50. So how did they time my awakening so well...?!?!? I noted he started me out with a CC of something that I have never "tasted" before... LOL .. (perhaps an antihistamine) Must be some magic up and down formula they have devised.... I also suspect they can pretty much time how long propofol acts with precision if not incorporating other drugs...

It should be noted that I have discussed with countless people who all say there is no better awakening that after Propofol. Always exclaiming how rested and well they felt afterwards...

I'm probably one of those folks that would not have survived medical school in anesthesiology. I hear they tend to get to "involved" with their studies...

BUT SERIOUSLY... WOULDN'T AN OPIOID-FREE SURGERY EXPOSE A PATIENT TO A SERIOUS AMOUNT OF PAIN TRAUMA CONSCIOUSLY, ALTHOUGH NOT "Awake"..!?!?!?!?!?

I just read some of that article you posted...
“The anti-fentanyl antibodies were specific to fentanyl and a fentanyl derivative and did not cross-react with other opioids, such as morphine. That means a vaccinated person would still be able to be treated for pain relief with other opioids,” said Haile.

Did not get far enough to see how permanent this "Vaccine" is because the notion creeps me out so much.... But even tho the state all other opioids would remain effective. That scares the shit out of me. Especially considering the Value of Fentanyl in the surgical environment ESPECIALLY FOR OPIOID TOLERANT PAITIENTS.. I mean they would have to go thru GALLONS of Morphine to keep you down for an extended surgery. Just does not sound realistically SAFE...
 
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So. @Mr. Keefe. WHO really is to blame. WHAT is the intended outcome of measures to date. WAS this truly an intent to fix a problem, or more like an attempt to expedite an ugly end for those involved that backfired on the world.... DO YOU EVEN HAVE A CLUE THE TRUE NET RESULT TALLY NOT EVEN BEGUN YET....!!
This is really a strawman criticism of Keefe's book. I wouldn't try to infer the content and perspective of the book based on the reviews. Keefe is extremely critical of many of the issues you raise and quick to recognize the limitations of his work. The book is damning imo.
 
The first excellent video, made me think about many things. I didn't watch the second one, I'm waiting for the book :)
This book sent me down the rabbit hole and I ended up buying a couple more books referenced by Keefe namely Dreamland, Pain Killer, and Dopesick.

I already read Dreamland and while it was good and expanded and added to the context covered by Keefe, it wasn't nearly as well-written and engaging and more than a bit repetitive.

I would have enjoyed it much more if I read it first. But in a back to back comparison with Empire of Pain, it was disappointing.
 
This is really a strawman criticism of Keefe's book. I wouldn't try to infer the content and perspective of the book based on the reviews. Keefe is extremely critical of many of the issues you raise and quick to recognize the limitations of his work. The book is damning imo.
And I disclaimed as such prior to my diatribe...

Thank you for the response. It's no secret that I am a strong proponent of opioids in the practice of medicine.. And I did disclaim that my criticism's primary target was at the review's from Keefe's peers, who's reviews are somewhat self-limiting in natural bias. And while the opposite can also be true as peers can become potent and dangerous foes just the same, clearly GREAT CARE FOR CALCULATION IS INVOLVED. I simply do not like to see this potential GROUP THINK spiraling out of to control seemingly and to no discount of the likes of Ellen DeGeneres's personal, but obviously powerful public position. Consider THE IMPACT that each and every one of these "reviewers" has over the minds of every potential civil juror on the face of the planet. And while hidden more often these days, folks ARE losing their ability to think for themselves. So one opinion from a "Press market maker" holds the power of seven degrees of separation, as even hearing from someone, that so and so head from someone, that someone said something, is now epidemic and becomes mainstream unchallenged BELIEF unchallenged. These public and press figures alike in fact think they are the Gods of Opinion and THAT IS DANGEROUS, especially in a world of sheeple. All all to many times do we see the bloated public trend setters their sails turn as much as 180 degrees not only after moving their market base on board, but then again once more steering folks heads into the prevailing winds blowing in their pompous heads and right out their hot mouths, EVEN in leu of the prevailing winds of FACT and TRUTH... So they do this over GRAVES AND AT THEIR FOLLOWERS EXPEN$E - Potentially. And all so ironically just to steer them back wherever they should get an (r)itch to take their markets. Its is also no coincidence usually that this is WHAT THE $MAJORITY$ wants to hear... Succinctly put, I am extremely concerned and disappointed as to where out public celebrities and trend setters have taken their power, and how they are using it, and the reason$ why.

I cant help but look at the underlying facts about the entire situation as a whole, brass tacks first and foremost with me. Which is that the Sacklers DID NOT invent oxycodone, but a variation there of which is in short a simple time release mechanism, which in no way makes them modern scientific "Lex Luthors" and far from "rocket scientists". I would argue that just because the Sacklers were "smart businessmen", with a real and medically valuable product, simply does not convict them because of the fact that it is the END USER that created the ULITMATE avenue of mis-use. The good old demand that has fueled this DEMOCRATIC REPUBLIC in which we, as US Business and citizens alike have all enjoyed alike.

Do you really believe that Pillsbury or McDonalds pulls any punches in their quest to be the best. Do you not think that "gray areas" are manipulated all day long in this quest? Perhaps they should put cameras in doctors offices so that we can all witness the legalized prostitution ongoing AKA "Drug repping"? But then again you would have to do that in any business environment because the simple fact of the matter is understanding that when you are trying to convince a person to do something, it just some happens that the reptilian brain is going to prevail, and thus the same things that SELL TO SELL - tend to work across the board. ! But I digress and IRONICALLY not even applying to the subject matter of Oxycontin because its generic and dirt cheap and needs no introduction to a pain patient. And why again is it that a specific company, advertising method, or specific product fall out of public favor. Do you think that when these changes take place that we get a accurate depiction of how the general public as a whole feels about it?! So again why is it that this company and product has fallen to be trampled under foot by the powers that be.? AND WHY ONLY THIS COMPANY as a public martyr? I wonder when the Patent rights on Oxycontin were set to be up for generic manufacture? Well let me look that up. As it turns out Oxycontin was approved in 1995 which would have put it up for generic manufacture in what? DRUMROLL 2013.... That happens to the be year that all this banning started. And guess what even though the ban was not in effect yet the FDA ruled in 2013 that OxyContin would NOT BE ALLOWED for generic reproduction due to concerns that new manufacturers would not be able to replicate mixing glue with oxycodone. RIGHT. OR one could think in a manner that might get you labeled as a "conspiracy theorist" and hypothesize the timing might just be to SET UP A SCAPEGOAT FOR CIVIL PUNISHMENT. As opposed to having other manufactures in the mix..

Which all goes to show the follow of trying to operate your own small business as opposed to setting up the grand corporations. As small business owners endeavoring large feats are less likely to have enough talent to see thru walls as they have a tendency to keeping hands on control. My guess is their legal is a family relation and unfortunately unqualified. I your are out their Sackler's, I will work for fee as a business consultant which it would appear you need to fresh perspective.....! And I am no atty, no scientist, not even sane. But I have common sense.... (No offense intended we all have out breaking points). Just saying objectively..

I also could not help the "evidence" that the above mentioned "reviewers" seems to have a running theme. Which is how Keefe's presentation was so "riveting", which of course infers the use of dramatics, which infers a tendency towards bias, which can potentially come full circle to AGENDA via "Story telling". And we all know that the best stories tend to embellish. I have never studied Keefe or his methods, as opposed to others . But I and coming to understood keef as having a general "flair" to his work, as opposed to the washington post (Cohn) remaining more conservative in his approach to reporting. You can put anything Ellen says on the stack of paper for when you fun out of proper toilet paper, and well as anything I write, unless you just want to hear idiot banter.. In fact I think I have heard some press critics as stating that if you want leftist bs look to the NYT, and if you want more classic non-biased reporting then go to Washington Post. If find that of interest considering you would think the Washington market to be just about as liberal as the NY market. But then again Keef is apparently a "Story Teller" in fact as he writes for THE NEW YORKER and not NYT, however, clearly allied. So I guess keefe really does not pretense to be a "reporter" in the first place. The proof.

I have got good money that says most if not all of these "Critical reviewers" have a bottle of opioids in their house, and when I can not get a single fucking tablet.!!! And believe me I know FOR A FACT that anyone with any professional success or "clout" in this society still has access to opioids because I know plenty of them. And probably half of them manufacture by the Sackler Family of Companies. L........... O................ L...................

It was YOUR positive take on the story that caused me to take interest, as opposed to simply dismissing the entire catalogue of accusations against the Sacklers, as I certainly respect you opinions. It is on my list of reads. I must admit I have a passion for SCIENCE FICTION (get it.. I made a funny:D).. LOL

Thanks Millard. That was a refreshing call to duty for the bbc.!!:);):p
 
AND WHY ONLY THIS COMPANY as a public martyr?
You make a lot of good points. The best imo is why was Purdue the only Pharma company that most associate with in connection with the prescription opioid epidemic?

Why doesn't anyone know about Mallinckrodt?

(Mallinckrodt is SpecGx)

10-biggest-prescription-opioid-manufacturers.jpgbiggest-opioid-manufacturers-wapo.jpg

Source: https://www.washingtonpost.com/investigations/76-billion-opioid-pills-newly-released-federal-data-unmasks-the-epidemic/2019/07/16/5f29fd62-a73e-11e9-86dd-d7f0e60391e9_story.html
 
You make a lot of good points. The best imo is why was Purdue the only Pharma company that most associate with in connection with the prescription opioid epidemic?

Why doesn't anyone know about Mallinckrodt?

(Mallinckrodt is SpecGx)

View attachment 177563View attachment 177564

Source: https://www.washingtonpost.com/investigations/76-billion-opioid-pills-newly-released-federal-data-unmasks-the-epidemic/2019/07/16/5f29fd62-a73e-11e9-86dd-d7f0e60391e9_story.html
Well, and @Millard. Lets have some fun with numbers and letters... You can read the last paragraph first in order to decide if you want to work your way through all this banter I post as a simple but pricipled man with nothing better to do. I have not bothered to edit this content in this post and the point being is all the typos, informational errors, and all shortcomings of a novice writer such as myself. Is still enough to speak for itself.

Sooo,,, in 2013 the patent on OXYCONTIN is set to expire soon. So evil power upon us has decided to destroy the United States by removing opioids from the market carte blanch, and with seeming pure disregard for all the negatives this will generate.

- They need a scapegoat as backlash creates "pudding proof". Someone must pay..!!!!!
- Oxycontin has gained considerable notoriety even though one of the most difficult opioids to abuse by its inherent design..
- Its also an innovation created by a small family owned company (purdue) that actually managed to make a mark in this world called OXYCONTIN.
- Keep in mind Purdue currently held the Patent on Hydoromorphone(dilaudid - the notorious "K4" changed to "P4") as well as manufacturing the whole gammit of generic opioids. Not really so small, but none the less privately owned. And much deeper pockets that the surface information to the public indicates.
- A family company large enough to have earned some serious financial clout, but small enough in terms of organization to push around. Keep in mind the sacklers and Purdue also own several subsidiaries apparently.
- Coincidentally as this patent is set to expire in 2013-2015 exact date unclear, but none of the competition is complaining that the FDA has now stated OXYCONTIN wont be allowed to go generic for bullshit reasons. And why would they being "in the know" of the complete shit storm on the horizon.
- Now imagine a group of dark suits coming in and telling the Sacklers "we can do this the easy way, or the hard one.".
- The EASY WAY being that in exchange for you taking one for the team, we will allow you to maintain exclusive rights to the concept of time released Oxycontin for a period indefinite and thus retain all future profits from said drug sales.
- And hey! the world is going to need a fix so we will allow one of your subsidiaries to hold that too an in the form of SECONDARY PATENTS. Possibly buprenorphine and suboxone.... (I am not going that deep by the point is made)
- The HARD WAY being we not only put you in a civil bind, but we go after your personally CRIMINALLY as well. And I do believe Purdue remains a privately held company with ZERO corporate veils of protection.!
- But the net result also effectively taking the "civil legal eye" off all the other generic companies.
- ( I wont discount the fact that Endo Phara took the hit of being slaughtered over OPANA/oxymorphone). So others did suffer, so why the sacklers so publicly endorsed for retribution?? Endo has huge tree brances as well owning subsidiaries with names like PAR Pharma which they aquired in 2015 and interlaced with several apparent Chapter 11 corporate restructures post the demise of the original Opana formulation. But you can see the depth to which the incredible political/business extends.



And endo is into much more than just the pain game, as they apparently settled some 1200 lawsuits REGARDING TESTIM.

I also find it amusing to see so many references in these large drug conglomerates always citing " AGREED TO PURCHASE" in terms of acquisitions.

- And it can easily be noted that Opioid like hydromorphone and oxymorphone are going NOWHERE long term and due to their value in hospital settings as they lack the failure of quick tolerance that classics like morphine possess.

So in even deeper review of the events to date it would appear that perhaps the sackler's legal division far from inept, and there has been an "exchange for profit" of sorts thus incentivizing the seemingly negative position the sacklers appear to have assumed over Oxycontin. Appear that is.... Its just not even close to the presented publication of frontline political stooges such as The New Yorker's KEEFE which portray in their apparent complicity with the whole hornswoggle of events. But it does make for great drama in story telling... Keefe is not reporting or writing about rocket science it would seem, but he is more like a mechanism for a very small facets of what appears to be the THUNDERDOME of the political business side of big pharma... And finally in which only further indicts the potential involvement of FAKE NEWS which IN and apparently rampant in todays society..

And to answer the earlier posed question as to WHY PUDUE and SACKLERS the optimal publicly villified scapegoats. It may turn out its because their primary and sole product lines being pain management, and whereas the other pharma companies in the pain game being more diversified on their surface pre-subsidiary level of business.

And all this information revleaved on the most basic of internet searched by even morons the likes of myself...
 
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I'm done rationalizing, justifying, and trying to determine who did what. The point of this thread is what are the powers that be going to do now to stop the onslaught of illegal drugs resulting from this improper abrupt abolishment of opioids which they created, and when are these powers that be going to realize this snowball is about to go over a cliff if something is not done to correct the course of events ASAP..!!! As we are clearly on the verge of a CATACLYSM...!

But hey and on a lighter note speaking of cataclysms - lol. Asteroid Apophis is right around the corner now and set to arrive in 2029 for the first potential swipe at earth. But nothing to see there either. Its only publicly scheduled to pass within 20,000 miles of Earth and the size of the Rose bowl (if nothing changes in 6 more years of travel). No worries about a "keyhole pass" then either, which would pull it in for direct impact possible on its way back out again in 2034 or 2036 I forget.. For perspective the moon is about 250,000 miles away. And Apophis minimally will pass MINIMALLY much closer than our man made satellites orbit n 2029. But NOOOO.. No worries... That's only a Potential DINASAUR KILLING EXCTINTION LEVEL EVENT.. Drug czars ending the US or interstellar rocks. What's the difference in the end...o_O:rolleyes::)
 
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I find it amusing all the advertisement lately as if they have sealed the deal and all the opioid fuss is in the past. And of course omitting other substance and its current role and effect in society.

The lack of personal responsibility for folks' decisions and life choices has reached levels of negligence and depravity now dwarfing the Roman Empire. From frivolous litigation succeeding when folks spill hot coffee (which was indeed that wrong left turn at Albuquerque) on themselves and then complaining that they were burned, to a society that allows children to dictate to their parents, and when a company is held liable for misuse of a product that was manufactured to strict quality guidelines - SOMETHING IS WRONG... This is all the equivalent of cranking up the oven and placing your head inside and then blaming someone that no "head protection" was installed... Except TODAY, somehow it appears like so much fun that all your friends have to try it too. And after all, the first thing to fail on a product is the luxury safety features. So how long till we create a world of false comfort and faux security just waiting to break. And all at once. But in short we are creating a world of idiots to which pick up wild snakes and then wonder why they got bit. How does this apply to medical science and prescribing in the US today? Can anyone follow directions anymore? How is it that a person's poor moral code and simple inability to follow directions results in false culpability of drug manufacturers and prescribing physicians.?? And why are others made to pay for another man's sins?

Or are opioid pain medications just an opportune target due to the specific market, and larger more protected markets are causing improper attacks and martyrizations. Why not go after companies poisoning the environment? Or creating products with real hidden dangers? Or Criminals committing atrocious crimes? Why is "Civil Legality" so opportune for attack and duress.? Are physicians just fish swimming SHARKS.? Are they that weak. Yet ever so important? Its not adding up... And I have news for you opioids were dirt cheap there was no monsoon of profit making taking place.

The folks abusing Opioid pain medications KNEW WHAT THEY WERE DOING. So to ponder where this all stops, we must also consider where and how it started. Civil litigation fueled by Government intervention is not helping matters either. What is the real purpose of regulation, or lack thereof. Is there some unseen agenda, aside from general insanity and social malfeasance? And if so what is it? Because the situation is turning on its side right now and once it flips like a ship its going straight to the bottom. THE SAME CONUNDRUM OF IDEALS, BEHAVIORS, AND VALUES is affecting other avenues of life equally now... The "Opioid Crises" was merely a symptom of a failing society as a whole. Translated - Opioids just may not be the PROBLEM...

The recent unprecedented Practicing of Medicine by the US DEA on this broad and arbitrary scale is improper and unsettling to the security of the democracy of the United States of America. Generalized threatening and terrorization of legitimate pharmaceutical retailers, as well as physicians is further diminishing the capacity of the US Health Care Market to operate objectively and effectively. Thus resulting in an overall diminishment of the practice of health care in the United States. Doctors should not live in fear of doing their jobs properly. The net psychological effect on practicing physicians is damaging on a fundamental level which spills over negatively into all forms of illness and treatments to which they address. Not to mention the financial and legal burdens passed down in cost to consumers and health insurance providers. The initiative was poorly constructed and implemented.
1. Yes certain areas of opioid use in medicine required more control.
2. Opioid users and abusers will get their drugs one way or the other.
3. The re-scheduling of Hydrocodone and essentially the removal of available opioids from the legitimate healthcare market is creating CRIME AVENUES - which due to their nature, most likely can not be undone.
4. New illegal opioid and illegal drug distribution chains and paths which will never be destroyed once started. Illegal Chinese market makers are dumping Fentanyl on the US market. Amongst every other illegal and improper vectors which are venturing to profit from this new opportunity. FENTANYL IS TOO SMALL IN PHYSCICAL SIZE TO CONTROL AND PREVENTS IT'S ILLEGAL DISTRIBUTION. PERIOD. (Poor Planning PERIOD)
5. New chemical analogs, similar drugs, and other illegal drug types are now also being designed, created, and distributed too quickly to regulate.
6. Creation of counterfeit pill markets using fentanyl and worse MANUFACTURED BY HACKS that improperly construct fake pills contain improperly high if not lethal doses of active ingredient - Fentanyl.
7. Re-birth of heroine markets. Heroin also now tainted with fentanyl which is even more deadly and all to increase profit.
8. Increased DEMAND for other illegal drugs in attempts by drug users and legitimate pain sufferers to compensate.
9. Legalization of MEdical Marijuana for PAIN Mitigation IS NOT a proper solution, as this market opening up is enabling youth to misuse and essentially retarding the upcoming generation irrevocably. It's a no-brainer that marijuana damages mental development in developmental adolescents. Let's not forget that marijuana is a SCHEDULE ONE SUBSTANCE (What is going on here!?!?!!!). DEA Drug scheduling is based PRIMARILY on POTENTIAL FOR ABUSE.
10. Creation of NEW ILLEGAL DRUG CONSUMERS AS FUNDAMENTAL CHANGE IN CONSUMER MARKET PSYCHOLOGY EMERGES.
11. Removal of legal prescription opioids HAS NOT lowered the death rate. (This means it has INCREASED IT - FYI....)
12. The demonization of hydrocodone , as a specific drug, was political at best. All told to date...
13. It would be a safe to speculate that all middle aged hydrocodone users that WERE/ and before 2014 and now EITHER (a) Dead, (b) Suffering and disabled due to discontinuation, (c) Using alcohol and other substance to compensate loss of access to hydrocodone.
14. Hydrocodone was a fairly safe and extremely effective pain medication which was demonized and banned in an arbitrary inclusion into the opioid control re-regulation efforts. Its not unfair to speculate that the re-scheduling of hydrocodone to a schedule II controlled substance was politically and unjustifiably motivated; and with poor pre-thought and planning. While hydrocodone is also abused by some users, the negative effects of said drug in terms of overdose deaths, perceived off-label market value, and most notably addictive properties - WAS IMPROPERLY REPRESENTED AND GROSSLY EXAGGERATED. It has been demonstrated in clinical studies that the addictive and other negative effects of hydrocodone are dwarfed by other lines or stronger opioids, including oxycodone.
15. The partial illegalization (State to state determinant) of the natural opioid substitute KRATOM, was pre-mature and most likely improper. The biological action of Kratom DOES APPEAR to be partially effective in terms of pain mitigation at the Opioid MU Receptor, and with minimal negative effects including market abuse. Kratom appears safely cost prohibitive and also appears to have limited lethality in use. Kratom sales and distribution control should be re-evaluated in all states at this time. In short, Kratom makes most users WANT TO BARF....
16. A complete re-evaluation of the war on opioids in terms of medical market use and distribution lines is strongly encourages AT THIS TIME.
17. BEFORE IT'S TOO LATE...
18. Lastly and certainly not least, it should be noted that converting pain patients to other analgesics such as NSAIDs is improper and poorly conjectured as the negative effects of NSAID pain medications from long term use will be catastrophic in terms of gastric and vascular damage -minimally... With consideration of the emerging positive data on the "Value of the gut" which is an ORGAN unto itself, AND which may even be the only ORGAN to elicit DIRECT CONTOL over the BRAIN, NSAIDs MAY BE CATASTROPHIC with long term chronic use. It is well documented that NSAID medications damage the gut resulting in anemia generating ulcerations, damage to mitochondria, and most likely a myriad of other biological intestinal disorders, permanent kidney damage and STROKE. NSAID USE ALONE may very well result in many illnesses with consideration of the emerging data on the broad and CRITICAL functional value of the gut. As a longer term more indirect and insidious negative consequence of long term NSAID use, these medications may ALSO very well cause vascular damage on a colossal scale which could possibly result in population-wide blood clotting disorders requiring anti-coagulant medication for MANY users ultimately. Are we looking at an NSAID APOCALYPSE of brain-warped, gut-failed, blood-clotted zombies?? Seriously..

And trust me - NO ONE cares about tomorrow. Else they would be working for today. You will be left to fend for yourselves. As you are now already.

SO what is the true cost? You say, "Oh, you are being irrational, eventually the demand will go away and this will be successful.." But at what cost...? And somehow the latter experience always seems to expedite the the eventual expedition of principle conditions.
- Rampant alcoholism and its sociological effects on physical health, psychological health, and resulting consequence in action of intoxicated behavior.
- Do you think these folks running around shooting up malls are on opioids? Don't think so. Drunk or stoned perhaps. Why don't we hear these STATS?!!!
- How much money in alcohol rehabilitation cost. After all the two PRIMARY TRIGGERS to enabling a trip to a REHAB are ALCOHOL AND BENZO's, as these have been deemed the two drugs which are considered "immediately life threatening upon direct cessation of use".
- How many people will go into the ER bleeding out internally from NSAID related ulcers?
- How many people will have heart attacks and strokes from NSAID USE?
- What is the COST of the long term effect of NSAID USE.
- How many children will die after being given a new drug analog which is now created due to the opioid crackdown? FYI - Kids were not really even into pain pills. Not before all the hype anyway...
- How many people will drink themselves to death and how far down with early alcoholism from onlookers and exposed children trickle?
- How many more kids will see their parents drinking more and be more likely to drink themselves and get into accidents harming both themselves and others?
- Was the internet and proliferation of "social media" even considered in this decision to upheaval the opioid market. And how that expedites the other evils?
- HOW LONG TILL SOME DRUG DEALER THAT WOULD NOT HAVE EXISTED OTHERWISE CAUSES HARM TO YOU OR YOUR FAMILY...!!!!
- the list goes on and on and one...

WHY IS IT THAT THEY JUST DID NOT ALLOW THE BEAST TO SLEEP AND START MORE SLOWLY WITH THE CONTROL MEASURES??? WHY...? Because I THINK they woke it's mother.. And she's pissed....
Just a quick question:

Are you speaking about how people are filing law suits against oxy maker?

DT
 
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