Everyone's different, All I can tell you is at a low enough dose, there's no appetite suppression effect, As long as it's .25mg for Sema, an effective dose for diabetes, you should be ok insulin sensitivity and blood glucose wise.
Rarely though, .25 mg Sema still induces appetite suppression. If you go with Tirz, the minimum diabetes effective dose is 2.4mg, and much less likely to induce appetite suppression at that level, while still providing the insulin/BG effects you're seeking.
Both are not only sustainable, but intended and best used indefinitely. A rarity among pharmaceuticals, there's nothing but health benefits to GLP/GIP hormone supplementation. (with very rare exceptions).