SLU-PP-332 Dosing Confusion – Anyone Familiar with Receptor Activity / Best Practices?

[Matthex69]

Hey everyone,

I’ve been looking into SLU-PP-332 recently and noticed a huge discrepancy in dosing recommendations. Most fitness/biochem guys like Vigorous Steve suggest doses between 250 mcg and 1 mg max. But then you’ve got Chinese vendors selling 20 mg tablets, and a lot of users report feeling absolutely nothing at 1 mg only at much higher doses do they start to feel the real effects.

So what’s the deal here? Does anyone actually understand the mechanism of action, especially which receptors SLU-PP-332 activates ERRα and ERRγ and how that ties into effective dosing?

I’m also curious what the best timing strategy would be for taking it, and whether this compound needs to be cycled or if it can be taken continuously. Do you need to build up tolerance before it kicks in?

 

[Mac11wildcat]

The high dose people will never stop. 250mcg is the place to start. 500mcg a good dose. 750-1g pushing it. Preference for me is to take it AM and early PM (around training). I’ll wait for someone smarter to chime in on the rest.

 

[eery]

The high dose people will never stop. 250mcg is the place to start. 500mcg a good dose. 750-1g pushing it. Preference for me is to take it AM and early PM (around training). I’ll wait for someone smarter to chime in on the rest.

What have you personally seen from slupp332 at different doses? do you think it has many applications or would you only use it during certain time periods like prep or cruises/health phases?

 

[Middus]

The high dose people will never stop. 250mcg is the place to start. 500mcg a good dose. 750-1g pushing it. Preference for me is to take it AM and early PM (around training). I’ll wait for someone smarter to chime in on the rest.

If we go by animal studies alone, A human equivalent dose of 250 mcg would be like a pinch of salt to season a cauldron of meat..
Then again there aren't human studies for us to know whether to adopt heq of the mice dose or figure out where the effective dose starts from. However the original 250 mcg dose seems like guess pure work

 

[dick_starbuck]

Allegedly the human doses converted from the animal studies are in the milligrams not micrograms.

I will say around 1.5mg a day is where I saw the most results. To be fair I was using 1.5mg MOTS-C, 750mcg of reta, and 10mg methylene blue a day with it. So who knows what's really doing what.

 

[Mac11wildcat]

If you converted animal studies to human doses on most drugs you’d be dead or dying in very short time (Anadrol, Cardarine, etc). All doses we have are largely arbitrary. If you crank ATP production that hard on large doses of stuff like this you’re gonna have some pretty shitty issues down the road.
On that topic, make sure you’re using something like this with it: Amazon.com

 

[oldgrey]

What is most interesting to me is how it seems to affect people differently. I know some people who say they start to feel super "hot" on even 500mcg, whereas I can take 10mg and "feel" nothing. Used 3 different brands and many different doses and I don't seem to respond the way some people do.. Therefore, I truly think it is VERY individual. Always start with smallest dosage.
PLUS, now you not only have oral, but injectable versions... apparently that's another animal.

 

[dick_starbuck]

What is most interesting to me is how it seems to affect people differently. I know some people who say they start to feel super "hot" on even 500mcg, whereas I can take 10mg and "feel" nothing. Used 3 different brands and many different doses and I don't seem to respond the way some people do.. Therefore, I truly think it is VERY individual. Always start with smallest dosage.
PLUS, now you not only have oral, but injectable versions... apparently that's another animal.

I tried the injectable. Every place I put it swelled up so bad I had to stop after a week.

 

[oldgrey]

I tried the injectable. Every place I put it swelled up so bad I had to stop after a week.

damn, where did you get it from?

 

[Middus]

If you converted animal studies to human doses on most drugs you’d be dead or dying in very short time (Anadrol, Cardarine, etc). All doses we have are largely arbitrary. If you crank ATP production that hard on large doses of stuff like this you’re gonna have some pretty shitty issues down the road.
On that topic, make sure you’re using something like this with it: Amazon.com

Well for the like of Anadrol and Cardarine studies exist in humans.
Also one has to separate doses aimed at determining long term safety (toxicity in animal models) of a drug from tests for effectiveness.
The cardarine doses that showed a boost in mice energy levels are somewhat in line with heq calculations.
I doubt oral imbibition of 250mcg will do anything. Even if I was to extrapolate with bro science, many other agonists, whether of the PPAR, REV-erb or GLP receptors, usually have their dosages in the mgs..

 

[dick_starbuck]

damn, where did you get it from?

Chimera. A research chemical Grey area spot. Only place I could find with with injectable SLU.

 

[Luke391]

If we go by animal studies alone, A human equivalent dose of 250 mcg would be like a pinch of salt to season a cauldron of meat..
Then again there aren't human studies for us to know whether to adopt heq of the mice dose or figure out where the effective dose starts from. However the original 250 mcg dose seems like guess pure work

animal doses do not scale 1:1 to human doses. if it were so a normal test dose would be like 10grams.

 

[Sampei]

animal doses do not scale 1:1 to human doses. if it were so a normal test dose would be like 10grams.

That's why animal doses conversion to human have an specific equation and by that equation the average dosage should be 150/300mg day xD

 

[Middus]

animal doses do not scale 1:1 to human doses. if it were so a normal test dose would be like 10grams.

A 1:1 ratio for SLUPP mice dosage would be in the 2-4 g range

 

[Middus]

animal doses do not scale 1:1 to human doses. if it were so a normal test dose would be like 10grams.

In mice, one trial 30mg/kg and another trial 50mg/kg twice daily intraperitoneal.
Human equivalent = Multiply by 0.081. If feeling nerdy, get the actual weight of the mice and plot in to heq formula. As I'm to lazy for that, I'll just share a 'rough guide'.



As Rightly stated by @Mac11wildcat , these aren't cannon-law.
There have been therapies (especially immunity related therapy) where translating Mice safety doses to HeqDose resulted in death and disability.
But Just doing guess work based on several agonists out there makes me doubt the 250 mcg dose. If it works for you, well who am I to say It's not working for you?

 

[Mac11wildcat]

In mice, one trial 30mg/kg and another trial 50mg/kg twice daily intraperitoneal.
Human equivalent = Multiply by 0.081. If feeling nerdy, get the actual weight of the mice and plot in to heq formula. As I'm to lazy for that, I'll just share a 'rough guide'.

View attachment 323294

As Rightly stated by @Mac11wildcat , these aren't cannon-law.
There have been therapies (especially immunity related therapy) where translating Mice safety doses to Heq resulted in death and disability.
But Just doing guess work based on several agonists out there makes me doubt the 250 mcg dose. If it works for you, well who am I to say It's not working for you?

Completely fair.

I’ve also heard the mixed statements of feeling like you’re on jet fuel at 500mcg and others not feeling anything. Who knows.

When there is a severe lack of human data id always err on the low side. My first real run with it is coming here soon. Will be happy to report back.

 

[Ateam2023]

Completely fair.

I’ve also heard the mixed statements of feeling like you’re on jet fuel at 500mcg and others not feeling anything. Who knows.

When there is a severe lack of human data id always err on the low side. My first real run with it is coming here soon. Will be happy to report back.

whats your plan on dosages etc?

 

[Sampei]

I don't feel shit at the moment at 50/70mg 3x a day but I just started so who knows

 

[Middus]

I don't feel shit at the moment at 50/70mg 3x a day but I just started so who knows

I'm in the same boat. Sold all my unopened 250mcg bottles. Like many people I am guilty of not testing for isolated effect. I was taking 50mg preworkout and assumed it was the SLU that was causing warmth (Of which I hadn't actually checked to read anecdotes of warmth so that felt like some sort of confirmation). However I decided to drop Mots-c and NAD that I was also taking pre workout and didn't notice much warmth (that being said the weather was harsh that week). Anyway, I had a Hb test and my iron dropped and not knowing what to blame I simply dropped the SLU.
This is just my experience. Not sure it's tanking anyone's Hb/iron levels

 

[Mac11wildcat]

whats your plan on dosages etc?

I do what my coach says when it’s time to prep SLU isn’t in yet so don’t know the dosage but my guess is 250 to 500 up to 750-1mg max.