SLU-PP-332 has no oral bioavaiability

[Proud Pangolin]

I just wanted to share with you what i read in this study about SLU-PP-915 ( an supposedly oral bioavaiable SLU-PP-332.

So probably thats why you cant feel shit however this claim isnt backed here by any source/literature but it comes from the developers of SLU-PP-332 so yeah....

Is there any injectable SLU-PP-332 available in a big concentration? Even with an injectable form you would still have to inject like 100mg per day

 

[Duke309]

What paper is this from?

 

[Proud Pangolin]

What paper is this from?

https://www.sciencedirect.com/science/article/pii/S0022356525403000?__cf_chl_tk=8n0Lz1b0mmpj4aIXeLsY__puRQtVoBcWJlQImBO9pJU-1770818147-1.0.1.1-8cYjUlJIi77ut0Uoae20uGEB1gjSKwwxTvlb0d4g08I

 

[Proud Pangolin]

Fig. 1. SLU-PP-915 enhances exercise capacity and induces Ddit4 expression in a similar manner to SLU-PP-332. Running distance (A) and time (B) to exhaustion of male mice treated with an acute dose of SLU-PP-332 (50 mg/kg, i.p., black bar), SLU-PP-915 (20 mg/kg, i.p., gray bar), or vehicle control (intraperitoneal, white bar) for 1 hour before running (n = 6/group). Ddit4 expression from (C) quadriceps or (D) soleus from the same mice indicated earlier was determined by qPCR. Mice were euthanized when they reached exhaustion and tissues were collected (n = 6/group). ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; $P < .05, between SLU-PP-332 and SLU-PP-915.


However there is no empirical evidence for the claim. Meaning, they havent linked anything/put a reference to back it up

 

[Duke309]

I wasn't able to access the reference papers on SLU-PP-332 on sci-hub, but from what I can read from them they only looked at 332 with intraperitoneal administration and don't mention oral administration.

It could be possible that humans have oral bioavailability of SLU-PP-332, it is just worse than injection.

 

[SubparMarioBro]

However there is no empirical evidence for the claim. Meaning, they havent linked anything/put a reference to back it up

Correct. It’s just the people who developed SLU-PP-332 saying that their own internal tests have shown that it isn’t orally bioavailable. Presumably they’re lying about the drug they developed because they want you to think it’s garbage?

 

[Photon]

Is there any injectable SLU-PP-332 available in a big concentration? Even with an injectable form you would still have to inject like 100mg per day

You could try injecting the API directly like Test or Tren suspension and pray daily that it gets dissolved