SLU-PP-332 has no oral bioavaiability

[Proud Pangolin]

I just wanted to share with you what i read in this study about SLU-PP-915 ( an supposedly oral bioavaiable SLU-PP-332.

So probably thats why you cant feel shit however this claim isnt backed here by any source/literature but it comes from the developers of SLU-PP-332 so yeah....

Is there any injectable SLU-PP-332 available in a big concentration? Even with an injectable form you would still have to inject like 100mg per day

 

[Duke309]

What paper is this from?

 

[Proud Pangolin]

What paper is this from?

https://www.sciencedirect.com/science/article/pii/S0022356525403000?__cf_chl_tk=8n0Lz1b0mmpj4aIXeLsY__puRQtVoBcWJlQImBO9pJU-1770818147-1.0.1.1-8cYjUlJIi77ut0Uoae20uGEB1gjSKwwxTvlb0d4g08I

 

[Proud Pangolin]

Fig. 1. SLU-PP-915 enhances exercise capacity and induces Ddit4 expression in a similar manner to SLU-PP-332. Running distance (A) and time (B) to exhaustion of male mice treated with an acute dose of SLU-PP-332 (50 mg/kg, i.p., black bar), SLU-PP-915 (20 mg/kg, i.p., gray bar), or vehicle control (intraperitoneal, white bar) for 1 hour before running (n = 6/group). Ddit4 expression from (C) quadriceps or (D) soleus from the same mice indicated earlier was determined by qPCR. Mice were euthanized when they reached exhaustion and tissues were collected (n = 6/group). ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; $P < .05, between SLU-PP-332 and SLU-PP-915.


However there is no empirical evidence for the claim. Meaning, they havent linked anything/put a reference to back it up

 

[Duke309]

I wasn't able to access the reference papers on SLU-PP-332 on sci-hub, but from what I can read from them they only looked at 332 with intraperitoneal administration and don't mention oral administration.

It could be possible that humans have oral bioavailability of SLU-PP-332, it is just worse than injection.