Steroids gains vs HGH IGF-1 gains

[Vely19]

are gains made from HGH or IGF-1 more sustainable than gains made from steroids

 

[Type-IIx]

Not by any measure. GH/IGF-I increases total body size (mitogenesis) & muscle size (myogenesis), but the GH-R and IGF-IR are susceptible to tachyphylaxis (desensitization) due to reliance on phosphorylation and signaling pathways, unlike the AR that is up-regulated in human skeletal muscle by AAS. Human skeletal muscle hypertrophy and amino acid recycling is subject to impermanence, just as connective tissues are, due to metabolism and turnover.