Sublingual semaglutide/tirzepatide

[BigOldBastard]

I just saw a video from a compounding pharmacy on a sublingual semaglutide they make. Unfortunately there were no details in the video. Anyone tried this?

 

[Grey Spartan]

My TRT clinic has it but I have not tried it.

 

[iris]

@Ghoul will be here shortly to tell you it's a no go.

 

[Ghoul]

Retarded mad scientists in small town drug stores handing Eli Lily and the FDA everything they need to shut down the good compounding pharmacies.

 

[iris]

Told ya

 

[mochul]

The molecule is too large to get absorbed. And digestion will completely destroy it

 

[BigOldBastard]

The molecule is too large to get absorbed. And digestion will completely destroy it

Nope. They compound it regularly. It's also marketed as Rybelsus

 

[DugPrime]

Is insulin syringes illegal in your country?

 

[BigOldBastard]

Nope. They compound it regularly. It's also marketed as Rybelsus

The real question is how could you homebrew a sublingual with semaglutide or tirzepatide

 

[mochul]

Why can’t you?

 

[DugPrime]

The real question is how could you homebrew a sublingual with semaglutide or tirzepatide

With saline.

 

[mochul]

Nope. They compound it regularly. It's also marketed as Rybelsus

Well that is oral. It contains certain ingredients that makes it more stable thtough digestive system. But it’s not effective at all and the dosage is extremely higher than sub q sema

 

[mochul]

With saline.

I suggest you take some chem and biology classes before touching this drugs without your doctor consult

 

[BigOldBastard]

You just

Well that is oral. It contains certain ingredients that makes it more stable thtough digestive system. But it’s not effective at all and the dosage is extremely higher than sub q sema

You just said the molecule was too big to be absorbed. What did you think sublingual meant?

 

[iris]

Have a look at this

So far we have not seen any oral glp-1 RA drug being overly successful. And there is a reason for it. I don't think this will change as the most optimal application method for these drugs is via injections.

Oral GLP agonists will be prohibitively expensive for the foreseeable future.

The top dose requires 2800mg of the peptide PER WEEK, at a time when they're struggling to produce a tiny fraction of that.

A pharma exec said these will be exclusively marketed in wealthy western countries due to their cost. It will be a "last choice" option for those in desperate need but have insurmountable needle phobia.

 

[Ghoul]

Well that is oral. It contains certain ingredients that makes it more stable thtough digestive system. But it’s not effective at all and the dosage is extremely higher than sub q sema

Oral requires 90x the dose. It's absurd.

Throw in the tremendous variability via oral (or sublingual) and it's a completely impractical alternative.

 

[BigOldBastard]

Oral requires 90x the dose. It's absurd.

Throw in the tremendous variability via oral (or sublingual) and it's a completely impractical alternative.

Then why do compounding pharmacies make it? Why was Rybelsus developed? It's obviously just another method of administration, nothing absurd about it.

 

[BigOldBastard]

Has anybody made it? That's the only question say whatever opinions you may have regarding its efficacy

 

[iris]

Then why do compounding pharmacies make it? Why was Rybelsus developed? It's obviously just another method of administration, nothing absurd about it.

If I were to hazard a guess, from an uninformed point of view, it would be that the pill may do something about blood glucose, but not fat loss.

 

[Spaceman Spiff]

Nope. They compound it regularly. It's also marketed as Rybelsus

No it isn't. That's very different