Swolen hands fron Tesamorelin ?!

[Proud Pangolin]

So basically about 4 weeks ago i switched one (the dose before bed) of my three daily doses of 100mcg CJC no DAC + 100mcg GHRP-2 with 2mg Tesamorelin + 600mcg Ipamorelin.

(So morning and after the gym CJC and GHRP-2 and before bed Tesamorelin and Ipamorelin)

For the last couple of days i have like a really swolen feeling of my hands especially after waking up. Making a fist is hard and it hurts. Even grabbing something tight hurts. Monday i even had tge feeling my feet were swolen during legday but this kinda went away while my hand stayed the same/got worse.

Now this sounds like a typical GH symptom. Why typical? Well because when i ran GH i never had sideeffects.

This really surprises me becaue:
1. I woukdnt have thought that 2mg Tesamorelin + 600 mcg Ipamorelin is such a big difference to 100mcg (saturation dosage) CJC no DAC + GHRP-2.

2. I wouldnt have thought that Tesamorelin can actually raise my GH/igf-1 so much to create such sideeffects.


(Or my kidney fail and im going to die in a couple of days)

Anyways, i guess i cant really do.anything about it besides dropping the Peptides (which i wont) ?

 

[IndividualMan]

2mg tesa & .6mg Ipa is a bit high, no? 1 full vial of 1 compound (fine on its own) & 3x the usual dosage of the other?
CJC no DAC +Tesa/Ipa would be a better combo.
Only way to combat this is to drop the peptides/lower the dosage.
also, get bloodwork. you do not know what your current IGF is. Do you even have a baseline reference for IGF?

 

[Proud Pangolin]

2mg tesa & .6mg Ipa is a bit high, no? 1 full vial of 1 compound (fine on its own) & 3x the usual dosage of the other?
CJC no DAC +Tesa/Ipa would be a better combo.
Only way to combat this is to drop the peptides/lower the dosage.
also, get bloodwork. you do not know what your current IGF is. Do you even have a baseline reference for IGF?

Well 2mg is the dosage that was unsed in studys and is prescribed in the USA

And why would i pair a GHRH (cjc no dac) with another GHRH (Tesamorelin). The sole reason why im not using 3x Tesmorelin + Ipamorelin ist the price.

Obviously you need 20x more Tesamorelin per dosage than CJC no dac and 6 times more Ipamorelin than GHRP-2
(most say that 400mcg is enough, officially i decided to go.with 500mcg but as im always pulling a little more into the syringe its probably closer to 600mcg)

And on top of thise Tesamorand Ipamorelin are significantly more expensive than CJC no Dac and GHRP-2.

Seriously even at 3x daily CJC no DAC + GHRP-2 is comically cheap to run.


And about the igf-1 values:
I actually dont have my baseline however i know how high my igf-1 was with GH and with CJC +GHRP-2

Where i live doing bloodwork is not only expensive but its very time consuming. Money wouldnt even be the problem but you need to get a doctors apointment first to talk about it. The next free date is.going to be in like 2 months. Simply to tell.the doctor in 20 seconds that you simply want to do a bloodwork. Then you will need to come.two weeks later (if you are lucky) for the blood test.
(Funny enough i just had a bloodsample taken today for thryoid hormones and no it was impossible to also add igf-1 to it because im not an official.patient of them or some bs like that... anyways)

So yeah bloodwork is a pain in the ass and also i dont really know how that would help me.

Igf- 1 ranges are so high ane symptoms accure at very individual levels. So even with a baselevel wont tell me much.

 

[endtropy]

I've been taking 1mg tesa nightly, I also only run it five days a week. Maybe consider cutting back on daily dosing and or breaking on weekends?

 

[IndividualMan]

Well 2mg is the dosage that was unsed in studys and is prescribed in the USA

And why would i pair a GHRH (cjc no dac) with another GHRH (Tesamorelin). The sole reason why im not using 3x Tesmorelin + Ipamorelin ist the price.

Obviously you need 20x more Tesamorelin per dosage than CJC no dac and 6 times more Ipamorelin than GHRP-2
(most say that 400mcg is enough, officially i decided to go.with 500mcg but as im always pulling a little more into the syringe its probably closer to 600mcg)

And on top of thise Tesamorand Ipamorelin are significantly more expensive than CJC no Dac and GHRP-2.

Seriously even at 3x daily CJC no DAC + GHRP-2 is comically cheap to run.


And about the igf-1 values:
I actually dont have my baseline however i know how high my igf-1 was with GH and with CJC +GHRP-2

Where i live doing bloodwork is not only expensive but its very time consuming. Money wouldnt even be the problem but you need to get a doctors apointment first to talk about it. The next free date is.going to be in like 2 months. Simply to tell.the doctor in 20 seconds that you simply want to do a bloodwork. Then you will need to come.two weeks later (if you are lucky) for the blood test.
(Funny enough i just had a bloodsample taken today for thryoid hormones and no it was impossible to also add igf-1 to it because im not an official.patient of them or some bs like that... anyways)

So yeah bloodwork is a pain in the ass and also i dont really know how that would help me.

Igf- 1 ranges are so high ane symptoms accure at very individual levels. So even with a baselevel wont tell me much.

??? are you EU based? Germany possibly?
just go to an independent lab. they got one in every major city, and you do not need a doctors referral for it. 5-10 bucks for most blood markers, 20 for test & e2, IGF pricing can be all over the place. they send the results via Email or you can pick them up in person.

also, just stacking secretagogues to the sky is a stupid way to go about this. either take the cheap shit, the normal amount of the expensive stuff, or just take regular old GH. works the best, unless you are specifically in it to get less fat, in which case tesamorelin is slightly more effective.


Also, IGF baseline is pretty dang important. my IGF for example is above reference for my age, so taking exogenous GH below 3-4 IU/day ( Pharma Norditropin or Chinese UGL does not matter) is useless for me. slightly above 2IU/day puts me in the exact same place. Secretagogues also dont do much for me, only 10-20% increases at max. dosages, like 40mgs MK677. I would not have known that that was the case without baseline IGF.

 

[masternak]

Swollen hands sound rough, man. Maybe try backing off the Tesa a bit and see if it helps? ‍

 

[Proud Pangolin]

??? are you EU based? Germany possibly?
just go to an independent lab. they got one in every major city, and you do not need a doctors referral for it. 5-10 bucks for most blood markers, 20 for test & e2, IGF pricing can be all over the place. they send the results via Email or you can pick them up in person.

also, just stacking secretagogues to the sky is a stupid way to go about this. either take the cheap shit, the normal amount of the expensive stuff, or just take regular old GH. works the best, unless you are specifically in it to get less fat, in which case tesamorelin is slightly more effective.


Also, IGF baseline is pretty dang important. my IGF for example is above reference for my age, so taking exogenous GH below 3-4 IU/day ( Pharma Norditropin or Chinese UGL does not matter) is useless for me. slightly above 2IU/day puts me in the exact same place. Secretagogues also dont do much for me, only 10-20% increases at max. dosages, like 40mgs MK677. I would not have known that that was the case without baseline IGF.

Yes! Germany! Independent lab is a good idea for the future.

Well the thing is, GH is a lot more "complicated":
1. As you said, it may not make sense to take only 4IU

2. You have to monitore you bloodsugar

3.Even though not a big risks with moderate dosages, you stilk have a risk for unwantes tissue growth because you are not only avoiding the negative feedbackloop but also eliminating another regulatory mechanism: pulsative GH release.

4. Pulsative GH is a lot more anabolic. Basiacally the sytemic igf-1 level doenst tell you much. For anabolism the autocrine igf-1 is relevant. Thats why you have such huge difference in anabolic responses with similar igf-1 levels. Thats also the reason why even though systemic igf-1 didnt continue to increase in studys with more than 6IU rHGH but bodybuilders report more anabolic effect with higher dosage.
In lower rHGH dosages sytemic igf-1 has even a negative effect on autocrine igf-1 which seems to be overwritten at higher dosages and of course while rHGH increases systemic igf-1 which may surpress autocrine igf-1 it also increases autocrine igf-1 at the same time.

Its complicated and i havent understood it completely yet but i tried to break it down.

So Peptides or to.me.more accurate GH pulses increases autocrine igf-1 a lot better and are therefore more anabolic (in context of the same GH release/level)

Also i even saw bloodwork of some guys who achieved higehr igf-1 levels with peptides than with 4 and even 6IU hgh if you believe them. (Bloodwork was posted but of course you cant verify if they actually took 6IU HGH)


I also wanted to attack my lovehandels so thats why i chose Tesamorelin. Also based on my feeling and well now the swolen hands, Tesamorelin is a lot more potent than CJC-no dac.

At the same time im not a fan if MK-677 or CJC- WITH DAC because

1. MK-677 makes you very hungry
2. You get a constant GH release resukting in basically exactly the same problems (insulinrwsistance) as with HGH
3. I dont think its such a good idea to hammer you p. gland constantly.

I really dont see the point in unsing MK-677 or CJC with DAC by anyone. Sole purpose would be if somebody is already on GH (meaning your gland is already shut down) and you are taking MK-677 for bulking because its Gherelin action and very long halflife makes you hungry the whole da