Broskie
Member
Well, dantrolene is the treatment for malignant hyperthermia (the cause of death from DNP OD); but there exists no dedicated reversal agent for the compound.
To my understanding; dantrolene is more of a symptomatic treatment rather than the cure; and only time without hyperthermia is curative while the chemical clears.
There was some very recent research I read last year that just painted an ominous picture of DNP overdose regardless of medical intervention. the title of one of them was "Dantrolene is not the answer..." or something like that.
I would assume that not all ODs result in death; but I think some degree of disability is certain with overdose.
Medicine is not my field of expertise; but I read and studied it enough to give the compound the highest level of respect and attention to detail.
On the other hand: I believe, if used in moderation in respect to dosage and time, DNP is one of the better products for fat loss; in that, it has no adverse effects on the heart. Sibutramine, phentermine, and the other stimulant medications seem to all have some increased risk of cardiovascular problems.
And don't get me started on clenbuterol: I know people love it but the only time I was ever really concerned for my life from a drug was after my first and only dose of clenbuterol. A man's heartbeat should not shake the bed while trying to sleep-----this I know for sure.
"We present a case of a healthy 25-year-old girl who took two tablets of DNP, purchased from an overseas online retailer. She was managed with aggressive, invasive cooling measures and 2.5 mg kg–1 dantrolene. Despite this, her temperature continued to rise exponentially to 41.5°C. Cardiac arrest occurred and resuscitation was unsuccessful. To our knowledge, this is the first reported case of the ineffective use of dantrolene in acute DNP poisoning. We review the pathophysiology of DNP toxicity and argue that the use of dantrolene therapy is biochemically implausible, based on poor evidence and likely to be futile. We have contacted the UK National Poisons Information Service (NPIS/TOXBASE) to propose changes to the management of acute DNP toxicity."
"2,4 Dinitrophenol Associated Hyperthermia Treated Successfully with Dantrolene
Louise Kao, James Mowry Indiana University, Indianapolis, IN, USA
Background: 2,4 Dinitrophenol (DNP) has well known toxicity. Dantrolene has been been successfully used in a single case report. We report another case of dantrolene use for DNP associated hyperthermia. Case report: 22 year old previously healthy male was found confused and diaphoretic. Upon arrival to the Emergency Department, he related that 4 hours prior he had taken a double dose of his bodybuilding supplements. Bottles provided included hydroxyzine, creatine, taurine, levothyroxine, and DNP. On presentation, his initial vital signs were normal other than mild tachycardia at 113 bpm. He was confused, diaphoretic and tremulous. The remainder of exam was unremarkable. Initial laboratory evaluation: Sodium 139 mmol.L, Potassium 4.1 mmol/L, Chloride 109 mmol/L, CO2 18 mmol/L, BUN 34 mmol/L, Creatinine 2.11 mmol/L, Glucose 499 mg/dL, TSH and T4 both in normal range, and Creatine phosphokinase 456 units/L. Toxicology testing including ethanol, acetaminophen, aspirin, and urine drug screen containing amphetamine, methamphetamine, barb, benzo, cannabinoid, cocaine, opiate, PCP were negative. 8 hours after hospital arrival, he was increasingly disoriented with severe respiratory distress. His vital signs were: T 38.6oC; HR 113 bpm; BP 114/45; RR 63 breaths/min; oxygen saturation 97% on 4 Liters of oxygen. He required intubation for respiratory failure. He was given dantrolene 180 mg intravenously. Temperature reached a maximum of 40.0oC. He received two additional doses of dantrolene over the next 10 hours for a total of 7 mg/kg. Hyperthermia resolved. He was extubated on hospital day #4 and discharged on hospital day #6 in good condition. Discussion: DNP has had a rise in popularity due to internet availability. DNP causes uncoupling of oxidative phosphorylation and clinical effects include hyperthermia, tachycardia, diaphoresis, and in fatal cases cardiovascular collapse. Dantrolene has been successfully used in a single published case report to our knowledge. Dantrolene may ameliorate the hypermetabolic state in DNP toxicity by lessening excitation-contraction coupling in muscle cells and thus attenuate hyperthermia. Conclusion: We present a case of DNP associated hyperthermia, successfully treated with dantrolene in addition to good supportive measures. This case adds to the sparse existing published evidence for the use of dantrolene in DNP toxicity."
It seems there are mixed results. Regardless, I would not expect dantrolene to save your life from a DNP overdose. Dantrolene is meant to treat malignant hyperthermia caused by volatile gaseous anesthesia in people who are genetically susceptible. Trying to treat anything else with it is a gamble.
"Dantrolene has been successfully used in a single published case report to our knowledge."
