I guess that might be the case if E2 dips too low, but you could also be like me and sleep better with better mood on low ish E2 and be more motivated to train harder and eat cleaner and bigger. High e2 lowers my appetite hard af.
Honestly I’m not convinced there is some linear increase in anabolism with e2 levels. Really just seems like there’s a minimal threshold for e2 to potentiate certain effects of test and DHT. To be fair, e2 likely also protects against certain effects such as hair loss from androgens too, but I doubt it’s that much more than that.
For reference, on my first test only cycle, all the so-called DHT-derived effects like tingly scalp, oily scalp, oily skin, moodiness, aggression were far more well controlled when I started controlling my estrogen more aggressively. Before that I legit felt like a burger from Wendy’s and could hardly get a good night’s sleep from the sweating and waking up
All this said, if I don’t see much of a difference from primo in terms of physique or e2 levels like 6-8 weeks out, I’m open to dropping it and maybe increasing test by a bit, all while still controlling e2 proactively. Might be a tough choice to make between either dropping primo or increasing it to try and garner some benefit from it
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