Ateam2023
Member
take as much as you can afford, just like hgh,,
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- Thread starter TheLobster
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The growth factor tgf ß tends to be elevated 15-20 days after last injection. It's also the one which promotes the creation of new blood vessels. I mean its main job is to push up the collagen synthesis for new tissue such as vessels.
Some articles suggest that its also the same pathway in which kidneys would usually get damaged through diabetis although research is very thin there. All they know its most likely caused through the tgf ß pathway which is why TB is also seen as cancer-progressing assistant as it uses the same pathway.
At the same time other studies suggest TB can help with diabetis induced nerve damage so yeah. Science doesn't seem 100% clear on it either.
Research is very thinn on this so i would take with a grain of salt, they are also talking about insanely high tgf ß values, not sure where it was posted but someone here said its like the equivalent of 20-25mg of TB a day.
Ateam2023
Member
again these links are just quick , basic information, as you investigate it further it gets easier to understand, but NOTHING beats good ol fashioned "feelz" on this , its very individualistic it seems, some swear by it, some Not so much,,
So bpc causes excessive red blood cells and not having any feelings or just an overall blah about everything? anhedonia…
Damn i got gut issues so i was hoping to give it a whirl to see if it helped fix some… but excessive blood cells and having a blah feeling might not be very productive…
Did not really came across anything in regards BPC, TB only in high doses and long term. The studies kinda remind me of Cardarine, some suggest it causes cancer some suggest its good against cancer.
As long as you dont overdo it with TB and run extraordinary doses like +20mg a day and still do some bloodwork just to monitor things it should be fine.
I have only seen 2 cases myself where someone had a crazy high red blood cell count after high-dose TB as part of an injury protocol. Seems extremely rare but still to be on the lookout for. (Both used more 5mg TB daily over a 3 month period)
Polycythaemia vera caused by TB was then treated with medication to slow down the red blood cell production.
Bodybuilders tend to just donate blood for that but in the long run that depletes your Iron levels and when you are on a GLP it makes it even more difficult for the body to absorb iron creating a devils cycle
Dirthand
Member
Feelings are way over rated.. You don't need them..
Do u know what drugs they used to slow that down or got a link so i can research further?
BamaCrazy
Banned
I couldn’t find that study but below are the drugs in use and some being studied.
Current drugs
Drugs being used in Clinical trials
- Peginterferon alfa-2a.
- Givinostat.
- Idasanutlin.
bigMoJo
Member
That's seriously interesting. Could you please link the study(/ies) associated with the increased hematocrit?
Those can be hard to get and should only be used as the last resort as they also have a bunch of side-effects
Look through the tgf ß, the growth factor which gets directly pushed up and greatly boosted by TB500 and its purposes i.e. blood vessel construction, red blood cell creation which starts a wide cycle of new tissue/cell (re)generation. It's not well studied at all, hence all the conflicting suggestions and articles you will come across
TheLobster
Subscriber
GERMANY, FRANCE, SPAIN, IRELAND, UK , BELGIUM, ITALY %99
What happened to Italy? XD
TheLobster
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Spaceman Spiff
Subscriber
PV is a precancerous blood condition/disorder(or cancer depending on who you are talking to)
I don't see how TB would cause PV. It's not curable either, just manageable
It happens very rarely but is a thing, medication that inhibits and slows down red blood cell creation is then used when other options no longer work like donating blood and with ferritin levels crashed. Science lacks studies in regards to that unfortunately to really draw a conclusion
All i could find is that its because of the tgf ß up regulation through TB.
BamaCrazy
Banned
I don’t either. I was just providing drugs that are used to treat the condition.
bigMoJo
Member
@Nidus
In your previous posts you cite "articles" and "studies" as your source for this information (TB500 in high doses causes Erythrocytosis, or Secondary Polycythemia Vera)...
I understand TGF-β (Transforming Growth Factor-beta) has been studied to "influence"
erythropoiesis (red blood cell production), but that's not the same as erythrocytosis (increased or significantly high red cell mass or red blood cells). Simply put... production versus saturation.
TGF-β can "influence" many physiological functions. However, a peptide (i.e. TB500) that may increase or promote TGF-β function doesn't necessarily equate to development to harmful degree.
It would be helpful if you could provide/cite a study where erythropoietin (EPO), and increase thereof, is actually measured. Otherwise, to surmise anecdotes from Reddit—the place where irrational ideas and flawed logic go to die—are accurate, warrants substantial "scrutiny."
bigMoJo
Member
Which medications?
Spaceman Spiff
Subscriber
Donating blood does not slow down blood production...
in PV they may use what @BamaCrazy mentioned.
Although Peginterferon is not being studied in trials... its approved.
Ropeg and Besremi
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