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AlexDavis43 said:
They have the same amino acid chain according to the Perplexity link Ateam posted. Frag lacks the aldehyde group, which increases it's stability. It doesn't make a whole lot of sense.

View attachment 323477

so I just basically agree with:
Click to expand...
again these links are just quick , basic information, as you investigate it further it gets easier to understand, but NOTHING beats good ol fashioned "feelz" on this , its very individualistic it seems, some swear by it, some Not so much,,
 
Nidus said:
Just be careful, BPC but mainly TB500 can boost TGFβ which also boosts production in red blood cell count and can lead to an increased hematocrit. Doesn't really happen that often but there are reports of people experiencing it on TB500.

Not saying it will be the case but just something to keep in mind.
Click to expand...

So bpc causes excessive red blood cells and not having any feelings or just an overall blah about everything? anhedonia…

Damn i got gut issues so i was hoping to give it a whirl to see if it helped fix some… but excessive blood cells and having a blah feeling might not be very productive…
 
Avies48 said:
So bpc causes excessive red blood cells and not having any feelings or just an overall blah about everything? anhedonia…

Damn i got gut issues so i was hoping to give it a whirl to see if it helped fix some… but excessive blood cells and having a blah feeling might not be very productive…
Click to expand...

Did not really came across anything in regards BPC, TB only in high doses and long term. The studies kinda remind me of Cardarine, some suggest it causes cancer some suggest its good against cancer.

As long as you dont overdo it with TB and run extraordinary doses like +20mg a day and still do some bloodwork just to monitor things it should be fine.

I have only seen 2 cases myself where someone had a crazy high red blood cell count after high-dose TB as part of an injury protocol. Seems extremely rare but still to be on the lookout for. (Both used more 5mg TB daily over a 3 month period)

Polycythaemia vera caused by TB was then treated with medication to slow down the red blood cell production.

Bodybuilders tend to just donate blood for that but in the long run that depletes your Iron levels and when you are on a GLP it makes it even more difficult for the body to absorb iron creating a devils cycle
 
Nidus said:
Did not really came across anything in regards BPC, TB only in high doses and long term. The studies kinda remind me of Cardarine, some suggest it causes cancer some suggest its good against cancer.

As long as you dont overdo it with TB and run extraordinary doses like +20mg a day and still do some bloodwork just to monitor things it should be fine.

I have only seen 2 cases myself where someone had a crazy high red blood cell count after high-dose TB as part of an injury protocol. Seems extremely rare but still to be on the lookout for. (Both used more 5mg TB daily over a 3 month period)

Polycythaemia vera caused by TB was then treated with medication to slow down the red blood cell production.

Bodybuilders tend to just donate blood for that but in the long run that depletes your Iron levels and when you are on a GLP it makes it even more difficult for the body to absorb iron creating a devils cycle
Click to expand...

Do u know what drugs they used to slow that down or got a link so i can research further?
 
Nidus said:
Just be careful, BPC but mainly TB500 can boost TGFβ which also boosts production in red blood cell count and can lead to an increased hematocrit. Doesn't really happen that often but there are reports of people experiencing it on TB500.

Not saying it will be the case but just something to keep in mind.
Click to expand...
That's seriously interesting. Could you please link the study(/ies) associated with the increased hematocrit?
 
Avies48 said:
Do u know what drugs they used to slow that down or got a link so i can research further?
Click to expand...

BamaCrazy said:
I couldn’t find that study but below are the drugs in use and some being studied.

Current drugs

Drugs being used in Clinical trials​

Click to expand...

Those can be hard to get and should only be used as the last resort as they also have a bunch of side-effects

bigMoJo said:
That's seriously interesting. Could you please link the study(/ies) associated with the increased hematocrit?
Click to expand...
Look through the tgf ß, the growth factor which gets directly pushed up and greatly boosted by TB500 and its purposes i.e. blood vessel construction, red blood cell creation which starts a wide cycle of new tissue/cell (re)generation. It's not well studied at all, hence all the conflicting suggestions and articles you will come across
 
Spaceman Spiff said:
PV is a precancerous blood condition/disorder(or cancer depending on who you are talking to)


I don't see how TB would cause PV. It's not curable either, just manageable
Click to expand...
It happens very rarely but is a thing, medication that inhibits and slows down red blood cell creation is then used when other options no longer work like donating blood and with ferritin levels crashed. Science lacks studies in regards to that unfortunately to really draw a conclusion

All i could find is that its because of the tgf ß up regulation through TB.
 
Nidus said:
Look through the tgf ß, the growth factor which gets directly pushed up and greatly boosted by TB500 and its purposes i.e. blood vessel construction, red blood cell creation which starts a wide cycle of new tissue/cell (re)generation. It's not well studied at all, hence all the conflicting suggestions and articles you will come across
Click to expand...
@Nidus
In your previous posts you cite "articles" and "studies" as your source for this information (TB500 in high doses causes Erythrocytosis, or Secondary Polycythemia Vera)...
Nidus said:
[...]
Some articles suggest that its also the same pathway in which kidneys [...]
Click to expand...

Nidus said:
Did not really came across anything in regards BPC, TB only in high doses and long term. The studies kinda remind me of Cardarine, some suggest [...]
Click to expand...

I understand TGF-β (Transforming Growth Factor-beta) has been studied to "influence"
erythropoiesis (red blood cell production), but that's not the same as erythrocytosis (increased or significantly high red cell mass or red blood cells). Simply put... production versus saturation.

TGF-β can "influence" many physiological functions. However, a peptide (i.e. TB500) that may increase or promote TGF-β function doesn't necessarily equate to development to harmful degree.

It would be helpful if you could provide/cite a study where erythropoietin (EPO), and increase thereof, is actually measured. Otherwise, to surmise anecdotes from Reddit—the place where irrational ideas and flawed logic go to die—are accurate, warrants substantial "scrutiny."
 
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