Tirz Fatigue - solid AAS cycle can help maybe?

[eryximachus]

I've been feeling fatigued since starting tirzepatide. I am on TRT only currently but have gear around ready to ramp up. I've been reading on reddit this is a common problem, and a purported benefit of retatrutide. I had been clinging to my med spa providing Tirz, but I'm at the point where I'm considering all options to help with the fatigue. Switch up the meds, ditch the meds, start an amping cycle, and so on.

Anyone else getting Tirz fatigue? Does it possibly go away once you hit 10+mg?

 

[Jfrost89]

Throw in some tesofensine 250 2xday. It amazing for its cognitive benefits as well as appetite suppression.

 

[KernelPanicFrenzy]

I've been feeling fatigued since starting tirzepatide. I am on TRT only currently but have gear around ready to ramp up. I've been reading on reddit this is a common problem, and a purported benefit of retatrutide. I had been clinging to my med spa providing Tirz, but I'm at the point where I'm considering all options to help with the fatigue. Switch up the meds, ditch the meds, start an amping cycle, and so on.

Anyone else getting Tirz fatigue? Does it possibly go away once you hit 10+mg?

am at 15mg, its only gotten worse the more ive done

 

[glpfun]

I was thinking of trying a low dose of modafinil to see if that combats the tirz lethargy

 

[Ghoul]

I was thinking of trying a low dose of modafinil to see if that combats the tirz lethargy

Combats all lethargy, but if you're not eating enough, you may find your appetite even weaker.

 

[Verivus]

I get intense fatigue the first 2 days post-injection on sema, then I feel normal for the rest of the week. It's not my deficit because I count calories and I always eat the same calorie-wise every day

 

[xrayphoton13]

What's impressive to observe among the Reddit weight loss peptide groups, besides people needlessly turning themselves into guinea pigs exposed to risks they're completely unaware of, is the psychological phenomenon of mass "folie à deux", aka shared delusions.

Setting aside the fact all of these drugs work just fine to provide significant, sustained weight loss without stacking or administering multiple times a week, but this "fatigue solved by Reta" claim.

Dive into the clinical trials, involving thousands of closely monitored users, and it's clear Reta induces a more rapid loss of weight, and as expected, a HIGHER rate of fatigue than Tirz, in line with the more rapid reduction in calorie intake.

I ran semaglutide and then tirzepatide over the last 2 years and lost 125 lbs. I never noticed fatigue. I do remember people talking about it on semaglutide but you never heard about it on tirzepatide. Not until reta got popular anyway. Then all the sudden everyone on tirzepatide is fatigued all the time. That certainly isn't what I remember in my own experience

 

[Ghoul]

I ran semaglutide and then tirzepatide over the last 2 years and lost 125 lbs. I never noticed fatigue. I do remember people talking about it on semaglutide but you never heard about it on tirzepatide. Not until reta got popular anyway. Then all the sudden everyone on tirzepatide is fatigued all the time. That certainly isn't what I remember in my own experience

Mass psychosis is a real phenomenon.

I could set up 5 fake profiles, start posting comments about Reta induced erectile dysfunction and an inability to orgasm all over the internet, and how switching to Cagri fixed it. In a couple of months I'm certain it would be "real" and "common knowledge".

 

[glpfun]

Mass psychosis is a real phenomenon.

I could set up 5 fake profiles, start posting comments about Reta induced erectile dysfunction and an inability to orgasm all over the internet, and how switching to Cagri fixed it. In a couple of months I'm certain it would be "real" and "common knowledge".

Why is mass psychosis more believable than some people responding to different drugs differently? People respond to different anabolic compounds differently so why wouldn’t these be different? Especially when they act on more receptors. Studies are great but only a small piece of the picture and not necessarily correct or reproducible, the bar for studies nowadays is significantly lower than it was 20 years ago

 

[Ghoul]

Why is mass psychosis more believable than some people responding to different drugs differently? People respond to different anabolic compounds differently so why wouldn’t these be different? Especially when they act on more receptors. Studies are great but only a small piece of the picture and not necessarily correct or reproducible, the bar for studies nowadays is significantly lower than it was 20 years ago

Because Phase III and extended clinical trials lasting multiple years, including over 10,000 closely monitored subjects, with only a minuscule percentage reporting that effect, nearly the same amount as were given placebo (water injections), vs the very large and ever increasing percentage of UGL Tirz users reporting this strongly suggests a psychosomatic effect.

That's why.

The entire reason for placebos being given to subjects in every clinical trial is because the power of suggestion is well understood to be a potent force capable of inducing many side effects.

 

[RekTest]

I dont remember people suggesting fatigue on tirz back when I was doing research and personally, I never got it.
I do believe, if you read something and you believe it, your body can create side effects, when otherwise they wouldn’t have been there.
Placebo effect?

 

[glpfun]

I dont remember people suggesting fatigue on tirz back when I was doing research and personally, I never got it.
I do believe, if you read something and you believe it, your body can create side effects, when otherwise they wouldn’t have been there.
Placebo effect?

I got tirz fatigue before ever hearing about it :shrug: guess I didn’t really cause the study said I shouldn’t

 

[RekTest]

I got tirz fatigue before ever hearing about it :shrug: guess I didn’t really cause the study said I shouldn’t

And what were you on? Solely tirz or a stack?

 

[glpfun]

And what were you on? Solely tirz or a stack?

Just tirz. Also worth noting the US pharma industry has a rich history of releasing drugs that have no issues during clinical trials and have issues later. Accutane during pregnancy, Trovan an antibiotic from the 80s and liver toxicity, a statin called baycol that gave people rhabdo, xigris for treating sepsis all kinds of examples I could keep going. Saying that everyone who is getting fatigue is the result of mass psychosis is incredibly dismissive of all the issues with clinical trials.

 

[RekTest]

Just tirz. Also worth noting the US pharma industry has a rich history of releasing drugs that have no issues during clinical trials and have issues later. Accutane during pregnancy, Trovan an antibiotic from the 80s and liver toxicity, a statin called baycol that gave people rhabdo, xigris for treating sepsis all kinds of examples I could keep going. Saying that everyone who is getting fatigue is the result of mass psychosis is incredibly dismissive of all the issues with clinical trials.

Why did you not at minimum run a TRT dose along side the tirz?

You cut calories and your test tanked. Like TANKED.
Theres videos of people documenting their test levels on cuts and they go literally from 7-800 to below 300 iirc

 

[glpfun]

Why did you not at minimum run a TRT dose along side the tirz?

You cut calories and your test tanked. Like TANKED.
Theres videos of people documenting their test levels on cuts and they go literally from 7-800 to below 300 iirc

My test was already tanked was like 219, I found out I had low t right when I was starting tirz and it took me a couple months to get started on a trt protocol, still too early to tell if it’s helping been only a week

 

[RekTest]

My test was already tanked was like 219, I found out I had low t right when I was starting tirz and it took me a couple months to get started on a trt protocol, still too early to tell if it’s helping been only a week

You wont know minimum 6 weeks, but I would bet your fatigue goes away

 

[psauce]

I know not everyone here is necessarily an athlete or bodybuilder, but if you are, you are more likely to have a different reaction to medications than most other people. That's especially true when the medication interacts with a molecule that is strongly associated to exercise response, whether it's designed training or just chasing your dog.

The *main* effect of the drugs will almost always function identically or highly similarly, because we all share a fundamental biochemistry. But how we use our metabolisms and the energetic demands we ask our bodies to adapt to are different. I don't have much trouble believing that, in some populations, fatigue is a noticeable side-effect.