Tirzepatide and Colitis Ulcerative.

[Alex2000]

Hi, I've tried to search but haven't found any information on this. Does anyone know if there are any contraindications for using tirzepatide in people with ulcerative colitis? Thanks.

 

[Wizbang]

I do not believe there are any contraindications, GLP-1s have been shown especially in animal models to have some benefit for crohns and UC type IBD.

 

[Spaceman Spiff]

Hi, I've tried to search but haven't found any information on this. Does anyone know if there are any contraindications for using tirzepatide in people with ulcerative colitis? Thanks.

What search are you using bro?

 

[Alex2000]

@Spaceman Spiff Sorry for my bad translation, what I actually meant was that i found studies showing clear improvements with the use of GLP-1s, and others suggesting they’re not recommended due to side effects like heavy digestion, diarrhea, etc.. so it's a bit confusing.
Thank you.

 

[BP_6]

Conds

@Spaceman Spiff Sorry for my bad translation, what I actually meant was that i found studies showing clear improvements with the use of GLP-1s, and others suggesting they’re not recommended due to side effects like heavy digestion, diarrhea, etc.. so it's a bit confusing.
Thank you.

Considering GLP-1's if you buy them on the underground market are currently very well priced, I would say give it a shot. For such a frustrating condition to have, I would think it would be worth it to give it a full run and see if it helps out.

 

[Spaceman Spiff]

@Spaceman Spiff Sorry for my bad translation, what I actually meant was that i found studies showing clear improvements with the use of GLP-1s, and others suggesting they’re not recommended due to side effects like heavy digestion, diarrhea, etc.. so it's a bit confusing.
Thank you.

That makes a lot more sense. I was a little confused when you we're asking such a basic question. For this type of sensitivity I would advise for you to reach out to your doctor

 

[Ghoul]

Hi, I've tried to search but haven't found any information on this. Does anyone know if there are any contraindications for using tirzepatide in people with ulcerative colitis? Thanks.

I've written about UC and GLPs before, but since you asked I've taken the opportunity to familiarize myself with the latest info.

No, there are no contraindications.

GLP's in general are known to improve intestinal health.

The safety of GLP-1s for UC patients is well established. If its active UC, start low, titrate slowly, stay well hydrated, be cautious of signs of significant flare ups, and stay in touch with your GI doctor, but flare ups appear very rare and anecdotal even with active UC.


There's a TON of research on animals and in vitro with human tissue that consistantly shows GLPs reduce UC symptoms. When it can be applied directly to the affected part of the colon it can even heal UC into remission. (novel meds to deliver GLPs like this are in development).

Retrospective studies show diabetics with UC or Crohns on GLPs vs other drugs to manage glucose have 50-60% lower risk of needing colon surgery.

So the short answer is, except in the case of severe active UC, Tirz is safe to use with UC. While randomized clinical trials haven't been done yet, there's significant observational evidence it helps ease symptoms, and stops or even reverses ulcerative colitis.

https://www.mdpi.com/2227-9059/13/5/1128#

"Surrogate data on better IBD composite outcomes have been reported with the use of GLP-1RAs, including a lower risk of surgery, hospitalization, corticosteroid use, and/or the initiation of advance therapies. "


Here's a clinical report of a case of complete remission of UC on a patient with a GLP-1.

A Novel Use of Liraglutide: Induction of Partial Remission in Ulcerative Colitis and Ankylosing Spondylitis

Ulcerative colitis and ankylosing spondylitis treatment options are limited to a few classes of medications at this time. Those options provide improvement for some patients, but leaves many with ongoing, unremitting symptoms. We report a case of ulcerative colitis (UC) with comorbid ankylosing...

www.clinmedjournals.org

Let me know if you want more studies on any particular point (safety, animal studies etc), I only linked what I thought most relevant.

 

[Alex2000]

Thank you all guys! I have some tirzepatide and I’ll start with the lowest dose

 

[verylargeshoes]

My UC is in remission thanks to Entyvio, so I can't talk about using GLP-1s with an active flare. But both Tirz and Reta have caused no obvious issues for my ulcerative colitis. My gastroenterologist's PA had no concerns with me starting a GLP-1. Definitely check with yours, though.

GLP-1s did lead to some constipation which isn't great, as I've also got some length of "redundant colon". I've had good results managing that with some oat fiber in my protein shake and a daily dose of MiraLAX. I tend to avoid psyllium as it can be irritating. The only other gastric effects I had were from Reta at a high dose (10mg/5days), when I had a long bout of hiccups due to (presumably) slow stomach emptying leading to vagus nerve irritation.

Definitely take the process slowly. It can take a couple of weeks or more to fully feel the effects of an increased dose. I got impatient and titrated up too quickly with Reta.