I think there is something to the once weekly dosing. Downregulation of some pathways support appetite suppression, then you're a little hungry for a day or two while they recover, then you hit 'em again.
Not sure these drugs are best utilized EOD. No studies, just speculation.
Plus once-weekly shows great results in clinical trials. I appreciate these anecdotal feedbacks tho
I've been using Sema, and then Tirz for years now, UGL and Pharma. Currently on 15mg Zepbound pens. Taking it once a week is the only way. Every other day is bro science treating GLP/GIP agonists like testosterone. These drugs are metabolism regulators, not stimulant like appetite suppressants that slowly wear off.
Once you reach stable blood level concentrations, you'll still feel hungrier on some days than others, but use it long enough and you'll realize that's based on your own metabolic cycles, and not the drug. You can find yourself hungriest 5 days after pinning, and then experience max suppression on day 6.
I have to use caution eating around noon, because it's easy to trigger sides by eating too quicky, while 3 hours later I can squeeze in a "cheat" without getting the dreaded "hiccup / puke" side effect.
Raising the once a week dose will raise baseline appetite suppression and squelch the hunger level on the days of least suppression, that's why you're supposed to titrate up. Novo Nordisk advises discontinuing if you can't make it to 1.7mg with Sema and Lilly advises discontinuing if you can't make it to 10mg with Tirz (more recently they added 7.5mg primarily for smaller females). It will still be up and down through the week and dependent on time of day.
GLP/GIP agonist effectiveness is based on the proportion of total receptors hit. They're everywhere, from your brain to nerves in your toes (where they exert a neuroprotective effect and stimulate neurogenesis, but I digress). It takes time and a steady dose to saturate them.
There is no "tolerance" to GLP/GIP agonists. A good analogy is to think of your body having a weight "thermostat". If your weight is below this setting your body will stimulate appetite using physical and psychological methods. You'll think about food. Your mouth will water at the sight of food. Your sense of smell is heightened. Above that set weight and it uses the same bag of tricks to push you back down. Food seems unappealing, your stomach contracts, you may experience acid reflux. These drugs change the setting on that "thermostat". If it's hypothetically 200lbs at a dose of 5mg, and you're above that, it'll suppress appetite. As you get closer to that weight, appetite suppression will lessen, then stop. Put on 10lbs and appetite suppression will return, 20lbs and it'll get even stronger.
Trying to "even it out" is a fools errand and you end up creating peaks from multiple doses that cross each other and lead to awful side effects. Just increase the once a week dose.