Tirzepatide max dosage

[anon55]

Hello mesoRx !
I'm currently on tirzepatide 20mg once a week and no longer feel it. I can eat and think about food, even do cheat meals almost like I used to do. Weight is not going back. But I hate the food noise, my diet is becoming harder to maintain.
Should I increase the dose to 25 mg weekly? To be honest I kinda want to try if needed up to 30mg weekly.
What's your thoughts? Is there really risks? More than those that we know? Have someone tried those huge dosages?

Thanks

 

[anon55]

From 81 to 59kg 1m72, Started in august 2024.
Currently stacking with mirabegron 100mg, 24mg of salbutamol, 100ug T4 ,32.5 T3 and melanotan II. I started few weeks ago testosterone undecanoate 200mg every two weeks.

 

[Ghoul]

Hello mesoRx !
I'm currently on tirzepatide 20mg once a week and no longer feel it. I can eat and think about food, even do cheat meals almost like I used to do. Weight is not going back. But I hate the food noise, my diet is becoming harder to maintain.
Should I increase the dose to 25 mg weekly? To be honest I kinda want to try if needed up to 30mg weekly.
What's your thoughts? Is there really risks? More than those that we know? Have someone tried those huge dosages?

Thanks

First, a plateau is normal, the "maintenance dose". But weight regain is not.

Secondly, while the max dose for pharma is 15mg, we know there's a safety buffer in there, since the max applies to everyone from. 4' 100lb woman to a 6'7" 400lb man, and there is a mg/kg dose response.

Finally, in my experience, UGL is about 25% weaker at the same dose as pharma. so 20mg is close to 15mg pharma in effect.

Personally I see little risk in 25mg, possibly 30mg, but I'm not endorsing that.

If you start regaining, say more than 5% at the same dose. Something's wrong and needs to be looked into, like a bad batch.

Finally, be sure you're diluting each dose to .5ml.

 

[anon55]

First, a plateau is normal, the "maintenance dose". But weight regain is not.

Secondly, while the max dose for pharma is 15mg, we know there's a safety buffer in there, since the max applies to everyone from. 4' 100lb woman to a 6'7" 400lb man, and there is a mg/kg dose response.

Finally, in my experience, UGL is about 25% weaker at the same dose as pharma. so 20mg is close to 15mg pharma in effect.

Personally I see little risk in 25mg, possibly 30mg, but I'm not endorsing that.

If you start regaining, say more than 5% at the same dose. Something's wrong and needs to be looked into, like a bad batch.

Finally, be sure you're diluting each dose to .5ml.

Thank you very for the answer. I will give a try then. I reconstitute and inject right after, usually with 0.75mL up to 1mL subQ.

 

[anon55]

I initially wanted to add a GLP1/glucagon receptors agonist instead such as mazdutide, survodutide or pemvidutide but these are hard to find labtested and costly.
I don't want to add reta because it might be to strong on the GIP side.

 

[Ghoul]

Thank you very for the answer. I will give a try then. I reconstitute and inject right after, usually with 0.75mL up to 1mL subQ.

That's good. Really no downside to over diluting other than over 1 ml can get uncomfortable.

The normal course of events is, you hit goal weight at a certain dose and stay there indefinitely, no noticeable effects or sides, just "normal" feeling. But of course not everyone gets to goal by 15mg. Sliding back would be an issue though, and isn't normal, since any weight regain should trigger a return of appetite suppression.

 

[dick_starbuck]

Have you thought about cargi/Sema as an addition?

 

[nickwhite]

How fast did you titrate up?

 

[AlexDavis43]

Have you thought about cargi/Sema as an addition?

In addition to tirz? Getting into wild west territory.

 

[dick_starbuck]

In addition to tirz? Getting into wild west territory.

Chase irons did a video on cargi/Sema with reta and raved about it.

The reta takes care of the nausea from cwrgi/Sema, and the cargi/Sema adds some nice appetite suppression since reta isn't GREAT for reducing appetite.

In my experience of being on reta for maybe 4 or 5 weeks now from 2mg to 3.5mg, there isn't much appetite suppression. More so reduction in "food noise". I recently added 2mg tirz to this and noticed more appetite suppression. Is this smart? I have no idea. Cargi/Sema or Sema on its own might have been better. Something like .25mg a week? I don't know.

 

[aljowa]

Finally, in my experience, UGL is about 25% weaker at the same dose as pharma. so 20mg is close to 15mg pharma in effect.

Would you say this "~25% weaker than pharma" rule of thumb could be applied to all UGL peptides (including GH)?

 

[PaintDrinker]

25mg ugl was fine for me, literally 0 sides. It was something like 99.7% purity tested not sure how much that matters with glps but had no issue on that dose. K4L 20mg tirz kits

 

[AlexDavis43]

Chase irons did a video on cargi/Sema with reta and raved about it.

It's the MO of a lot of online influencers to rave about new exciting compounds early when they come out, so their followers think they're getting cutting edge information. Then when things don't pan out, no one remembers, and they're on to the next thing.

Do they ever come out and say "yeah that compound I raved about wasn't as good as I originally thought"?

 

[rxzed]

It's the MO of a lot of online influencers to rave about new exciting compounds early when they come out, so their followers think they're getting cutting edge information. Then when things don't pan out, no one remembers, and they're on to the next thing.

Do they ever come out and say "yeah that compound I raved about wasn't as good as I originally thought"?

shiny object syndrome

 

[dick_starbuck]

It's the MO of a lot of online influencers to rave about new exciting compounds early when they come out, so their followers think they're getting cutting edge information. Then when things don't pan out, no one remembers, and they're on to the next thing.

Do they ever come out and say "yeah that compound I raved about wasn't as good as I originally thought"?

Yeah, Chase does actually. He makes jokes about when he was all in on the "safer use" bandwagon.

 

[Sampei]

Chase irons did a video on cargi/Sema with reta and raved about it.

The reta takes care of the nausea from cwrgi/Sema, and the cargi/Sema adds some nice appetite suppression since reta isn't GREAT for reducing appetite.

In my experience of being on reta for maybe 4 or 5 weeks now from 2mg to 3.5mg, there isn't much appetite suppression. More so reduction in "food noise". I recently added 2mg tirz to this and noticed more appetite suppression. Is this smart? I have no idea. Cargi/Sema or Sema on its own might have been better. Something like .25mg a week? I don't know.

Go to 10mg and we will talk about appetite suppression. Reta starting dosage is more like 4mg then 2mg.
So you ain't even there, before stacking shit I would arrive close to the max dosage.

I wouldn't stack anyway but that's your own choice of course

 

[dick_starbuck]

Go to 10mg and we will talk about appetite suppression. Reta starting dosage is more like 4mg then 2mg.
So you ain't even there, before stacking shit I would arrive close to the max dosage.

I wouldn't stack anyway but that's your own choice of course

You're probably right. I do like to try new things though. All roads lead to Rome eventually.

I'll either have a horror story to share or a good review so others can learn.

 

[noteablequotable]

I know you got a few downvotes because you're talking about deviating from currently approved protocols, but almost every GLP-1 is being tested for efficacy and safety at higher doses. I'll make a separate post with the details for anyone who is interested.

I can't give medical advice because I'm not a doctor, but increasing your Tirz dose is probably best. There will eventually be a study about the effects of whatever Tirz dose you end up taking, but we will probably never know the health impacts associated with some of these "stacked" combinations, especially at high doses.

 

[anon55]

How fast did you titrate up?

Great question, I started at 5mg and stayed at leat 3 months on it and then 7.5 mg for 1 months. I titrated up to 10 then 12.5 and 15 pretty fast. I'm on 20mg since 2 weeks
Thanks everybody for yours answers. I'm going to try 25mg next week.

 

[anon55]

Do you if tirzepatide effecf on receptors is linear or more like telmisartan or even like a statin?
Most of the benefits come from a low dose and after 15mg there no much differences like between 20 and 40 of rosuvastatin?