I’m currently on reta, and I’m wondering, from anyone who’s used both, how is the difference in appetite suppression strength between it and tirz? Lets say I’m on 5mg reta, what dose would roughly be equivalent to that in terms of appetite suppression with tirz? I know it’s probably individual, but in your experience how was it?
MESO-Rx
Anabolic Steroids
Tirzepatide vs Retatrutide appetite suppression strength
- Thread starter Dhtcoper123
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ostrichsak
New Member
Tirz certainly has a higher impact to the GLP1 receptors. Not as much as Semaglutide but certainly far more than Reta which, of the three agonists, the GLP1 is the weakest of the bunch. Hard to say how much, since everyone is different.
I'll assign an arbitrary # to it though to give you an idea but the hunger suppression of Tirz is at least 50% greater than that of Reta whereas Sema may be 100% greater than Reta & 50% more than Tirz.
Again, all arbitrary #'s but just to assign some sort of metric for conversations sake.
I've seen some people add in a little Tirz once per week at a start very low dose (if you got this route) strictly for the satiety effect. There was also some well-known "oops" scenarios where they were combined at the lab that were found in 3rd part testing (subtle reminder to test your peptides). I still think that this may have been more of a requested stack that got mislabeled or something along those lines more so than I think it was a legitimate mix-up by the labs.
Using a little Tirz w/Reta as the primary weight loss peptide may result in a lower Glucagon agonist (since you likely wouldn't be dosing Reta as high to titrate for weight loss if you're getting those other two agonist as overlap from Tirz also) so while it's common, I'm not sure it's the best way to go. Maybe for some though.
You can also check into Cagrilintide as well. This may be a better option if all you want is the satiety effects since Tirz will not only be adding a stronger GLP1 agonist to Reta but it will also increase the GIP agonist as well. Common dosage for this use is 1.5mg sub-Q once per week. I'd suggest starting with 500mcg though to see if that gets the desired effect.
Keep in mind that the half life of Cagri is about a week so it takes about a month of weekly injections to reach a steady-state in your system. It's best to give it a month to reach this level to see if it has the desired effect on hunger. If not, move up to 1mg and finally 1.5mg per week, if needed. You can go up from there but I'd take smaller steps and give the increased dose time to reach a steady state each time.
I'll assign an arbitrary # to it though to give you an idea but the hunger suppression of Tirz is at least 50% greater than that of Reta whereas Sema may be 100% greater than Reta & 50% more than Tirz.
Again, all arbitrary #'s but just to assign some sort of metric for conversations sake.
I've seen some people add in a little Tirz once per week at a start very low dose (if you got this route) strictly for the satiety effect. There was also some well-known "oops" scenarios where they were combined at the lab that were found in 3rd part testing (subtle reminder to test your peptides). I still think that this may have been more of a requested stack that got mislabeled or something along those lines more so than I think it was a legitimate mix-up by the labs.
Using a little Tirz w/Reta as the primary weight loss peptide may result in a lower Glucagon agonist (since you likely wouldn't be dosing Reta as high to titrate for weight loss if you're getting those other two agonist as overlap from Tirz also) so while it's common, I'm not sure it's the best way to go. Maybe for some though.
You can also check into Cagrilintide as well. This may be a better option if all you want is the satiety effects since Tirz will not only be adding a stronger GLP1 agonist to Reta but it will also increase the GIP agonist as well. Common dosage for this use is 1.5mg sub-Q once per week. I'd suggest starting with 500mcg though to see if that gets the desired effect.
Keep in mind that the half life of Cagri is about a week so it takes about a month of weekly injections to reach a steady-state in your system. It's best to give it a month to reach this level to see if it has the desired effect on hunger. If not, move up to 1mg and finally 1.5mg per week, if needed. You can go up from there but I'd take smaller steps and give the increased dose time to reach a steady state each time.
Ok, thanks for giving me a general idea! My problem is, I have a good deal on a kit of 30mg vials of tirz, but I don’t know if I will be able to use them up in time. I know that in general reconstituted peptides should only be used for 6 weeks. I just don’t know if I will be able to use 5mg a week haha. I’m currently on 5mg of reta and pretty suppressed. Worst case scenario I’ll have to just throw away whats remaining after the 6 weeks mark I guess. If GLP 1s don’t have some sort of longer shelf life I don’t know about but I doubt that.
ostrichsak
New Member
The official USP guidance is 28 days. Understand that your "6 weeks" is alreayd blowing pas that by 50% so it's not something to be taken lightly. That doesn't mean that I personally haven't gone past that but my process is iron clad. I buy from good sources and 3rd party test. That doesn't do much for contaminants though but the hope is that if the masses are good and they test well that the labs process hopefully involves top tier sterility protocols. It certainly doesn't guarantee it though.
I then filter using individually wrapped USP certified filters and use only USP certified vials to filter my peptides into. I also then keep them dark and refrigerated 100% unless I'm drawing to inject. When I draw I use proper sterility and cleaning protocols as well.
Assuming you're doing all of that... you can start taking more freedoms with that 28-day rule with slightly lowered risk. But the risk is always there. I'm fine with people pushing that timeline but it's improtant that they fully understand the risks associated and take every precaution within their power to keep things as safe as possible.
If you're cutting corners and buying peptides that are too large because the price is good you're going to end up in the hospital or worse to save ten or twenty bucks. Not very wise.
Choose your peptide weight based on the best "deal" is a poor plan. Always determine what your dose will be, try to project what it may be in situations where a titration is part of the plan (Reta & Tirz, for instance) and then find the best deal on the actual size you need. If you go for the lowest price per mg you'll end up with a 50mg+ vial that lasts you 8-9 months on your starting protocol. You'll throw over half of it out and even wasting all of that will likely still have you in a high risk timeframe for months.
I'd highly recommend that you don't do it. Throw the lyophilized powder in the freezer and get a proper size vial. 10mg is ideal if you're just starting out as you'll (likely) be on 1mg per week for the first month and titrating up to 1.5-2mg the 2nd month. Get yourself a 10mg vial and then plan to go to 15mg or maybe a 20mg the 2nd phase.
I sure hope you're not starting out on 5mg per week as your first time using a GLP1 peptide. Your 2nd post made it sound like that may be the case. If so, you're getting some terrible advice.
Reta shows no sign of significant degredation even past 90 days. Only thing that might happen is that the potency decreases.
Same goes for other peptides. If you are using a sterile environment and bac water, peptides in general will not degrade significantly (one could argue HGH as the exemption).
Same goes for other peptides. If you are using a sterile environment and bac water, peptides in general will not degrade significantly (one could argue HGH as the exemption).
Deezznutzz
Member
I had the opposite results. Tirz appetite suppression is way stronger than Sema. Have not tried reta yet.
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