This might be too obvious to say, but I haven't seen it mentioned yet so I'll add it just in case.
5ARIs like Fin and Dutasteride won't protect you against hair loss from Primo and Var. All these drugs do is compete with androgens to bind the 5AR enzyme. But Primo and Var don't interact with 5AR in any meaningful way, so Fin/Dut only protect you from your test base converting to DHT, not your Primo/Var. Primo/Var don't convert into any other meaningfully active metabolites the way test does with DHT/E2. So you can't manipulate that aspect and are stuck dealing with Primo/Var in their "final form."
If you suspect that Primo is accelerating hair loss, you would need to use a topical anti-androgen to compete with the Primo for binding to your scalp androgen receptors. These are drugs like
| RU58841 | Limited human testing; experimental; thought to be the most effective of the bunch. Kinda sketchy. |
| Pyrilutamide (KX-826) | FDA approved for OTC sale as a cosmeceutical. Decent human testing that suggests reasonable efficacy, but some question marks do arise where it performed similar to placebo at some points. |
| Clascoterone (Breezula) | FDA approved for acne (Winlevi), pre-approval for androgenic alopecia. Haven't looked into efficacy for AGA. |
| Fluridil (Eucapil) | OTC in some EU countries. Never heard of it being used in US. |
If you're not trying to go nuclear and take several drugs, the methodology
@Ghoul is recommending is sound. Take a 5ARI, and that'll neutralize the DHT aspect of your test base, which significantly lower your total androgenic load on your scalp. The minoxidil will help to slowly regrow part of what you've lost since puberty.
But you wanna have "full coverage," (protect against Primo and other AAS besides test) ya gotta add a topical AA as well. The most effective (but def the most sketchy) is RU58841, and the least sketchy but not-likely-as-effective-as-RU option (FDA approved for OTC sale) is KX-826, which you can buy directly from the pharma company that made it, Kintor. Google it, I think Koshine is the store they sell it from. On Amazon too. Kinda expensive, but worth it if you don't wanna dip into the RU58841 experimentation.
However, legit miniaturization (the permanent, unreversible death of hair follicles) is unlikely to be noticeable so quickly and discretely even on a 12-week cycle. So it might just be the AI effects of Primo making your hair look weak and brittle from low e2. Fortunately, if this is the case, your hair will return to normal once your e2 normalizes. There's also telogen effluvium, which is temporary hair shedding from stress and shit like that, which as I understand it, is pretty common on cycle.
So most likely, this thinning you're noticing is probably temporary. But if you care about your hair, and you have any reason to believe you're genetically predisposed to male pattern baldness (most hispanic men are to some degree), then this is a good wake-up call to start figuring out how to protect yourself, especially if you plan to blast into the future.
Good luck bro.
