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Anabolic Steroids

MESO-Rx Exclusive Trenbolone facts - series on unique characteristics of different steroids

mikeh1998 said:
That’s a really interesting anecdote thanks.

I’ve had a problem in the past couple of weeks where I always had to pee at 3-4 AM and couldn’t go back to sleep even after controlling water intake and so on.

Took some ashwagandha last night and that solved it, got a full actual 8 hours with good REM. Only change was that I was lazy asf and couldn’t get out of bed. Usually even if my sleep is trash I get out of bed pretty quick.

Probably too low cortisol, if I had to guess.
Click to expand...
I've heard some ppl cycle on and off of it. Sounds alot better than using it long term.

ofc if u get no zombie or annoying side effects, might as well keep it but just a suggestion.
 
Raiders789 said:
Yea bro 100% im glad you're feeling the same!

Just curious, what else are you running on ur blast? In my (limited)experience, I notice a huge difference in sides when looking at the dose relative to my total AAS intake at the time. Like on trt + microdosing tren I got pretty bad sides, but on a higher test + mast + var blast im using 4x the tren and getting way less sides and feel great. I'd figure it there must be some sort of relative androgen exposure that contributes to sides, and maybe this is why guys that do really high tren only cycles get horrible side effects.
Click to expand...
Hey brother, came across your post. Be easy with the Tren at High doses for other reasons not pertaining to mood. Tren sides dont magically disappear with more gear. It’s because tren behaves differently depending on what else you’re running, and the relative ratios of androgens can absolutely affect how you feel.

Tren sides hit harder when tren is the dominant androgen​

When you run:
TRT Test (low) + small tren dose
Your androgen environment is like 70% tren, 30% test.

Back when i first started Tren there was a 1:1 ratio recommended. Bro Science started dropping testosterone when on tren because of the "5x" strength of tren to test.
  • Testosterone stabilizes mood, dopamine, emotion regulation
  • Mast (DHT derivative) has anti-estrogenic, mood-boosting properties
  • Var (DHT derivative) gives clean energy and mental clarity
  • All together → they dilute the tren “neurochemical punch”
 
Last edited:
Nidus said:
Keep us updated on how it goes!
Click to expand...
Update here… I ran 100 mg Tren Ace pw.

I gained so much more muscle in that 10 weeks compared to any 10 week period that I used testosterone even at >500 mg pw.

I looked dry as hell and my face looked way more sexy and intimidating rather than a little puffy and soft.

Can’t remember my test dose at this time but it was probably 100 mg with 25 mg exemestane pw.

Tren really changed my personality for the better, now that I can analyze things in hindsight.

I generally became more willing to chase my goals rather than agonizing over what could go wrong or how behind I am. I became way more confident with women and they were super receptive to it.

I think a lot of the mental changes were caused by my appearance being so much better though. Looking better = higher self esteem = less procrastination/laziness because living just feels so much more “worth it”.

I do remember feeling like my sleep was a little worse but checking my Apple Watch data there really wasn’t a significant difference, so I think that was just in my head.

Btw I didn’t get any real strength gain from switching from high T to low T + 100 tren. Honestly idk what’s really wrong with me but it seems like since starting roids I am getting bigger but the strength gains aren’t really there? I train pretty hard 5-7x per week, each set 0-2 RIR, 25 sets per workout…

And on the first day of injecting tren ace I genuinely almost passed out from what I think was low blood sugar but my gym buddy saved me by getting me a Powerade. Kind of shocking that happened from a single 14 mg injection but since then I always carry Powerade with me.

I got bad shoulder acne and upper back acne from tren which I never got from test. But I’m on accutane now so not worried about that happening again.

I hated doing daily injections but want to run Tren again… 4 days ago I’ve started a new cycle…. 100 mg test, no AI, 400 mg Tren E pw. Split into 2 injections per week.

I know 400 is high but I can just lower the dose if I can’t handle it. I’m also injecting daily for the past 4 days so I can “frontload” it.

Going to run this for 15 weeks (so till March 3) goal being aesthetics aesthetics aesthetics. Wish me luck. I’m running HGH 2-4 IU per day too (for now just 2 IU but will titrate up maybe).

After those 15 weeks I’ll probably just switch to something like 250 test + 25 mg exemestane pw and then re-run tren a while later. Also considering stanozolol, oxandrolone to substitute tren but that’s another story.

I don’t really see myself returning to high T doses. I think that if I get bad androgenic sides (specifically hair loss) from tren I would quit it and use high testosterone + 5AR blockers instead. I’m 27 and have the thickest jet black hair out of anyone I know and 0 recession or thinning so far.

Tren.
 
mikeh1998 said:
Update here… I ran 100 mg Tren Ace pw.

I gained so much more muscle in that 10 weeks compared to any 10 week period that I used testosterone even at >500 mg pw.

I looked dry as hell and my face looked way more sexy and intimidating rather than a little puffy and soft.

Can’t remember my test dose at this time but it was probably 100 mg with 25 mg exemestane pw.

Tren really changed my personality for the better, now that I can analyze things in hindsight.

I generally became more willing to chase my goals rather than agonizing over what could go wrong or how behind I am. I became way more confident with women and they were super receptive to it.

I think a lot of the mental changes were caused by my appearance being so much better though. Looking better = higher self esteem = less procrastination/laziness because living just feels so much more “worth it”.

I do remember feeling like my sleep was a little worse but checking my Apple Watch data there really wasn’t a significant difference, so I think that was just in my head.

Btw I didn’t get any real strength gain from switching from high T to low T + 100 tren. Honestly idk what’s really wrong with me but it seems like since starting roids I am getting bigger but the strength gains aren’t really there? I train pretty hard 5-7x per week, each set 0-2 RIR, 25 sets per workout…

And on the first day of injecting tren ace I genuinely almost passed out from what I think was low blood sugar but my gym buddy saved me by getting me a Powerade. Kind of shocking that happened from a single 14 mg injection but since then I always carry Powerade with me.

I got bad shoulder acne and upper back acne from tren which I never got from test. But I’m on accutane now so not worried about that happening again.

I hated doing daily injections but want to run Tren again… 4 days ago I’ve started a new cycle…. 100 mg test, no AI, 400 mg Tren E pw. Split into 2 injections per week.

I know 400 is high but I can just lower the dose if I can’t handle it. I’m also injecting daily for the past 4 days so I can “frontload” it.

Going to run this for 15 weeks (so till March 3) goal being aesthetics aesthetics aesthetics. Wish me luck. I’m running HGH 2-4 IU per day too (for now just 2 IU but will titrate up maybe).

After those 15 weeks I’ll probably just switch to something like 250 test + 25 mg exemestane pw and then re-run tren a while later. Also considering stanozolol, oxandrolone to substitute tren but that’s another story.

I don’t really see myself returning to high T doses. I think that if I get bad androgenic sides (specifically hair loss) from tren I would quit it and use high testosterone + 5AR blockers instead. I’m 27 and have the thickest jet black hair out of anyone I know and 0 recession or thinning so far.

Tren.
Click to expand...
400mg of Tren E... you should be just fine. Tren A is the fickle one if not paying attention. E Kept me vascular and semi lean on a larger diet without the ED or EOD pins. Be easy but if you can handle the pre Slaughter Cattle Steroid.. Get after it.
 

Atherosclerotic and pro-inflammatory​

Trenbolone likely antagonizes MR (mineralocorticoid receptor)​

Impaired corticosteroid metabolism and activation of minerolocorticoid receptor (MR) has been associated with cardiovascular disease (Briet and chiffrin, 2010; Hadoke et al., 2009; Lastra et al., 2010). [10].

Antagonism of the MR inhibits the aldosterone-induced absorption of sodium ion (Na⁺) in the kidneys, collecting duct principal cells (Rafestin-Oblin et al., 2002), and affecting Na⁺ transport in the bladder. [11]. The principal consequences of MR antagonism are electrolyte disturbances (consequences of impaired aldosterone action) and the development of hypertension and cardiovascular disease.

Trenbolone, likely by acting analogously to the research steroid metribolone, antagonizes the MR, and so exerts atherosclerosis (plaque buildup in arteries) and inflammation, harmful to the heart.
Click to expand...

After 15 pages nobody noticed this? The last part doesn't make any sense.

If Metribolone = MR antagonist (blocks MR)
and drugs that block MR like eplerenone are used in heart failure for their cardioprotective effects. Then trenbolone which is similar to metribolone must also be an MR antagonist. This would mean tren lowers blood pressure, lowers inflammation etc.

The whole thing is backwards. I think you meant tren activates MR but there is no evidence of that and the since the part about metribolone blocking MR is correct, the whole argument was built on a backwards assumption.


@Type-IIx
 
juicebro said:
After 15 pages nobody noticed this? The last part doesn't make any sense.

If Metribolone = MR antagonist (blocks MR)
and drugs that block MR like eplerenone are used in heart failure for their cardioprotective effects. Then trenbolone which is similar to metribolone must also be an MR antagonist. This would mean tren lowers blood pressure, lowers inflammation etc.

The whole thing is backwards. I think you meant tren activates MR but there is no evidence of that and the since the part about metribolone blocking MR is correct, the whole argument was built on a backwards assumption.


@Type-IIx
Click to expand...

You are right about the logic error — MR antagonism by itself is generally cardioprotective, so the original post’s causal chain is backwards. But the original post is also partly right that tren (and tren-like drugs) are cardio-toxic — just via other mechanisms, not via MR antagonism alone.
 
Happy Madison said:
You are right about the logic error — MR antagonism by itself is generally cardioprotective, so the original post’s causal chain is backwards. But the original post is also partly right that tren (and tren-like drugs) are cardio-toxic — just via other mechanisms, not via MR antagonism alone.
Click to expand...
I'm not claiming tren is good for you. Just pointed out the error.

What you are saying is that steroids are bad for you and tren is one of them. We know that. No arguing about that. It's just that the article is called "Trenbolone facts".... Okay I know very well the research on tren is super scarce. I think the only study on tren and its cardiovascular effects is a study done on rats which only demonstrates positive effects lol.
 
juicebro said:
I'm not claiming tren is good for you. Just pointed out the error.

What you are saying is that steroids are bad for you and tren is one of them. We know that. No arguing about that. It's just that the article is called "Trenbolone facts".... Okay I know very well the research on tren is super scarce. I think the only study on tren and its cardiovascular effects is a study done on rats which only demonstrates positive effects lol.
Click to expand...

Hey, thanks for clarifying — I totally agree that it’s important to separate the mechanistic claim (the MR antagonism thing) from the broader, real-world risks of tren.

You’re right that research on tren is scarce, especially in humans — most of what we have is from animal studies or case reports. But that doesn’t mean it’s harmless. — not to argue for or against tren use, but to point out real concerns that go beyond the mechanism you mentioned.

That said, I’d add a few practical, evidence-based points so people don’t walk away thinking “no human data = harmless”:

Trenbolone isn’t approved for humans and controlled human trials are basically non-existent, so most of what we rely on are animal studies, case reports, and AAS (anabolic-androgenic steroid) literature.

There are multiple human case reports linking tren use to serious cardiac events (MI, heart failure, stroke). Case reports don’t prove causation for everyone, but they’re important warning signals because many users are young and otherwise healthy when these events happen

Broader AAS literature consistently shows cardiovascular risk (hypertension, adverse lipid changes, cardiomyopathy, pro-arrhythmic remodeling). Tren is extremely androgenic/potent, so it fits into that high-risk category even if some isolated animal models found short-term metabolic benefits.

Animal studies are mixed — some rat models show metabolic improvements or reduced infarct size in very specific conditions, but animal dosing, duration, and physiology differ from human recreational use, so you can’t safely generalize protective effects to people.




  1. Shahsavari-nia et al. (2014) – A Young Man with Myocardial Infarction due to Trenbolone Acetate
    • A 23-year-old bodybuilder developed MI (heart attack) after chronic tren use.
  1. Câmara, Costa Viana & Monte Alto (2024) – Adverse Effects of Trenbolone: A Structured Review of Case Reports in Humans
    • Systematic review of 23 human cases: most commonly reported adverse effects were cardiovascular (heart failure, MI, stroke), liver injury, kidney damage, and psychiatric issues.
 
Happy Madison said:
400mg of Tren E... you should be just fine. Tren A is the fickle one if not paying attention. E Kept me vascular and semi lean on a larger diet without the ED or EOD pins. Be easy but if you can handle the pre Slaughter Cattle Steroid.. Get after it.
Click to expand...
I have injected probably around 750 mg tren over 8 days to “kick off” my Tren E cycle…

I have legit become a little retarded. I think it’s because of sleep deprivation. Definitely have heart burn, breathing heavy, heart rate is up, worse sleep quality.

Going to just not inject for a few days and then go to a regular schedule of test/tren 75/175 Tues Fri for a total of 150 mg test 350 mg tren pw.

Wish me luck guys

1763843922957.webp
 
Happy Madison said:
Hey brother, came across your post. Be easy with the Tren at High doses for other reasons not pertaining to mood. Tren sides dont magically disappear with more gear. It’s because tren behaves differently depending on what else you’re running, and the relative ratios of androgens can absolutely affect how you feel.

Tren sides hit harder when tren is the dominant androgen​

When you run:
TRT Test (low) + small tren dose
Your androgen environment is like 70% tren, 30% test.

Back when i first started Tren there was a 1:1 ratio recommended. Bro Science started dropping testosterone when on tren because of the "5x" strength of tren to test.
  • Testosterone stabilizes mood, dopamine, emotion regulation
  • Mast (DHT derivative) has anti-estrogenic, mood-boosting properties
  • Var (DHT derivative) gives clean energy and mental clarity
  • All together → they dilute the tren “neurochemical punch”
Click to expand...
I have always advocated for Tren to not be run without test and mast. same with nandrolone. Needs primo or mast in there. The ratios you can play around with. I’m currently running 420 test, 350 mast, and 140 tren and I feel great. No side effects whatsoever.
 
Happy Madison said:
Hey brother, came across your post. Be easy with the Tren at High doses for other reasons not pertaining to mood. Tren sides dont magically disappear with more gear. It’s because tren behaves differently depending on what else you’re running, and the relative ratios of androgens can absolutely affect how you feel.

Tren sides hit harder when tren is the dominant androgen​

When you run:
TRT Test (low) + small tren dose
Your androgen environment is like 70% tren, 30% test.

Back when i first started Tren there was a 1:1 ratio recommended. Bro Science started dropping testosterone when on tren because of the "5x" strength of tren to test.
  • Testosterone stabilizes mood, dopamine, emotion regulation
  • Mast (DHT derivative) has anti-estrogenic, mood-boosting properties
  • Var (DHT derivative) gives clean energy and mental clarity
  • All together → they dilute the tren “neurochemical punch”
Click to expand...
stop spamming this thread with A.I bullshit
 
RockyP said:
I have always advocated for Tren to not be run without test and mast. same with nandrolone. Needs primo or mast in there. The ratios you can play around with. I’m currently running 420 test, 350 mast, and 140 tren and I feel great. No side effects whatsoever.
Click to expand...
Where do you come up with the odd weird numbers of doses 420 test 140 Tren - that’s so silly man lol
 
mikeh1998 said:
Data is from my Apple Watch

I wanted to start with a bang so I can titrate down later. I’m paying the price for that right now :)
Click to expand...
I feel like my heart is going to explode like a nuke whenever I walk more than 50 ft I’m a dumbass. Gotta wait for this shit to clear my system…
 
mikeh1998 said:
Update here… I ran 100 mg Tren Ace pw.

I gained so much more muscle in that 10 weeks compared to any 10 week period that I used testosterone even at >500 mg pw.

I looked dry as hell and my face looked way more sexy and intimidating rather than a little puffy and soft.

Can’t remember my test dose at this time but it was probably 100 mg with 25 mg exemestane pw.

Tren really changed my personality for the better, now that I can analyze things in hindsight.

I generally became more willing to chase my goals rather than agonizing over what could go wrong or how behind I am. I became way more confident with women and they were super receptive to it.

I think a lot of the mental changes were caused by my appearance being so much better though. Looking better = higher self esteem = less procrastination/laziness because living just feels so much more “worth it”.

I do remember feeling like my sleep was a little worse but checking my Apple Watch data there really wasn’t a significant difference, so I think that was just in my head.

Btw I didn’t get any real strength gain from switching from high T to low T + 100 tren. Honestly idk what’s really wrong with me but it seems like since starting roids I am getting bigger but the strength gains aren’t really there? I train pretty hard 5-7x per week, each set 0-2 RIR, 25 sets per workout…

And on the first day of injecting tren ace I genuinely almost passed out from what I think was low blood sugar but my gym buddy saved me by getting me a Powerade. Kind of shocking that happened from a single 14 mg injection but since then I always carry Powerade with me.

I got bad shoulder acne and upper back acne from tren which I never got from test. But I’m on accutane now so not worried about that happening again.

I hated doing daily injections but want to run Tren again… 4 days ago I’ve started a new cycle…. 100 mg test, no AI, 400 mg Tren E pw. Split into 2 injections per week.

I know 400 is high but I can just lower the dose if I can’t handle it. I’m also injecting daily for the past 4 days so I can “frontload” it.

Going to run this for 15 weeks (so till March 3) goal being aesthetics aesthetics aesthetics. Wish me luck. I’m running HGH 2-4 IU per day too (for now just 2 IU but will titrate up maybe).

After those 15 weeks I’ll probably just switch to something like 250 test + 25 mg exemestane pw and then re-run tren a while later. Also considering stanozolol, oxandrolone to substitute tren but that’s another story.

I don’t really see myself returning to high T doses. I think that if I get bad androgenic sides (specifically hair loss) from tren I would quit it and use high testosterone + 5AR blockers instead. I’m 27 and have the thickest jet black hair out of anyone I know and 0 recession or thinning so far.

Tren.
Click to expand...
ur main problem with getting strength gains is the incredibly high volume ur doing, yes youll get muscle gains but for strength its better to lift as heavy as possible for like 5-6 reps 2-3 sets max so ur total sets honestly shouldnt be over 9-10 for a day
 
mikeh1998 said:
Update here… I ran 100 mg Tren Ace pw.

I gained so much more muscle in that 10 weeks compared to any 10 week period that I used testosterone even at >500 mg pw.

I looked dry as hell and my face looked way more sexy and intimidating rather than a little puffy and soft.

Can’t remember my test dose at this time but it was probably 100 mg with 25 mg exemestane pw.

Tren really changed my personality for the better, now that I can analyze things in hindsight.

I generally became more willing to chase my goals rather than agonizing over what could go wrong or how behind I am. I became way more confident with women and they were super receptive to it.

I think a lot of the mental changes were caused by my appearance being so much better though. Looking better = higher self esteem = less procrastination/laziness because living just feels so much more “worth it”.

I do remember feeling like my sleep was a little worse but checking my Apple Watch data there really wasn’t a significant difference, so I think that was just in my head.

Btw I didn’t get any real strength gain from switching from high T to low T + 100 tren. Honestly idk what’s really wrong with me but it seems like since starting roids I am getting bigger but the strength gains aren’t really there? I train pretty hard 5-7x per week, each set 0-2 RIR, 25 sets per workout…

And on the first day of injecting tren ace I genuinely almost passed out from what I think was low blood sugar but my gym buddy saved me by getting me a Powerade. Kind of shocking that happened from a single 14 mg injection but since then I always carry Powerade with me.

I got bad shoulder acne and upper back acne from tren which I never got from test. But I’m on accutane now so not worried about that happening again.

I hated doing daily injections but want to run Tren again… 4 days ago I’ve started a new cycle…. 100 mg test, no AI, 400 mg Tren E pw. Split into 2 injections per week.

I know 400 is high but I can just lower the dose if I can’t handle it. I’m also injecting daily for the past 4 days so I can “frontload” it.

Going to run this for 15 weeks (so till March 3) goal being aesthetics aesthetics aesthetics. Wish me luck. I’m running HGH 2-4 IU per day too (for now just 2 IU but will titrate up maybe).

After those 15 weeks I’ll probably just switch to something like 250 test + 25 mg exemestane pw and then re-run tren a while later. Also considering stanozolol, oxandrolone to substitute tren but that’s another story.

I don’t really see myself returning to high T doses. I think that if I get bad androgenic sides (specifically hair loss) from tren I would quit it and use high testosterone + 5AR blockers instead. I’m 27 and have the thickest jet black hair out of anyone I know and 0 recession or thinning so far.

Tren.
Click to expand...
also if u insist on running tren that high use ru58841 at the very least to protect face skin and hair cuz once u lose collagen/hair its alot harder to recover it than prevent losing it
 
Happy Madison said:
Its accurate info.. Sorry it would take you a month to break it down with Crayola and a napkin pumpkin. Get with the times. Come down from your mums skirt
Click to expand...
just because it came from a.i does not mean it is accurate.
youre another one of these guys who thinks they are smart now lol.
dunning krueger effect

a month to break it down for me? like you aren't just copy and pasting a.i lmao
 
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