"Wegovy Rewired My Brain"

[Ghoul]

Something that's been casually observed for years, GLP class drugs soon to be a major component in treating addictions of all kinds.

“Wegovy rewired my brain. I have no desire for cigarettes and minimal desire for alcohol.”

How a Fortune 50 VP controlled his "20 pack-year" and a 5- to 6-drink a night habits.

recursiveadaptation.com

 

[Ghoul]

Trading one addiction for another for most weak useless folks, others might be able to develop good habits for the long term even after cessation of the GLPs...
but at least glps are improving health (we hope...) for the ones addicted to them long term.
I have my popcorn ready for the next decade ,either way this is going to be entertaining.

Fucking steroid abuser thinks we're not drug addicts. smh

Nothing says natural "strength" like injecting artificial hormones to assuage psychological issues, body dysmorphia and insecurity.

It's most likely the same age GLP "addicts" who'll be waving goodbye as your LVH or stroked out corpse is lowered into the ground.

 

[BeardedGuy]

I quit smoking while on Tirz. Today is actually 69 days nicotine free. Nice.
Longest ever adult nic free time.
Here’s something to note… I’m hungry again. In the beginning of Tirz, my “food noise” was totally under control. Now after quitting, it’s almost back to the old level. Even on Tirz, even with increased doses.
Thought: Is there only “so much” a GLP/GIP can do? If fixes one “issue” it’s maxed out and can’t help another “issue” too much? Just my anecdote.

 

[Ghoul]

I quit smoking while on Tirz. Today is actually 69 days nicotine free. Nice.
Longest ever adult nic free time.
Here’s something to note… I’m hungry again. In the beginning of Tirz, my “food noise” was totally under control. Now after quitting, it’s almost back to the old level. Even on Tirz, even with increased doses.
Thought: Is there only “so much” a GLP/GIP can do? If fixes one “issue” it’s maxed out and can’t help another “issue” too much? Just my anecdote.

Immunogenicity is a strong possibility.

It worsens when taking a break and returning to protein based drugs like GLPs.

Essentially an immunity develops, and your body clears it out of your system more quickly, causing a loss of effectiveness.

I saw this years ago when people "took a break" from Sema and suddenly everything was "bunk", but worked for others.

 

[BeardedGuy]

Immunogenicity is a strong possibility.

It worsens when taking a break and returning to protein based drugs like GLPs.

Essentially an immunity develops, and your body clears it out of your system more quickly, causing a loss of effectiveness.

I saw this years ago when people "took a break" from Sema and suddenly everything was "bunk", but worked for others.

I’ve never taken a break.
But that said, quitting was easier than ever. So, still a fan of “off label” uses.

 

[aljowa]

I quit smoking while on Tirz. Today is actually 69 days nicotine free. Nice.
Longest ever adult nic free time.
Here’s something to note… I’m hungry again. In the beginning of Tirz, my “food noise” was totally under control. Now after quitting, it’s almost back to the old level. Even on Tirz, even with increased doses.
Thought: Is there only “so much” a GLP/GIP can do? If fixes one “issue” it’s maxed out and can’t help another “issue” too much? Just my anecdote.

I’ve never taken a break.
But that said, quitting was easier than ever. So, still a fan of “off label” uses.

Congratulations on stopping smoking, that's huge. More power to you.

I recently introduced my mom to sema. She's been a smoker for 45 years. Less than two weeks in on 0.25mg/week and she's gone from a pack a day to under half a pack. I'm holding out hope that this can be the magic bullet that kills her addiction, but even if it just reduces her smoking I'll consider it a win.

 

[BeardedGuy]

Congratulations on stopping smoking, that's huge. More power to you.

I recently introduced my mom to sema. She's been a smoker for 45 years. Less than two weeks in on 0.25mg/week and she's gone from a pack a day to under half a pack. I'm holding out hope that this can be the magic bullet that kills her addiction, but even if it just reduces her smoking I'll consider it a win.

The biggest challenge I’ve found with Tirz, potentially more so w Sema, is to just simply listen to your body. We do SO MUCH out of habit… why snack? It’s snack time, that’s why.
It’s so hard to push through.

 

[Ghoul]

The biggest challenge I’ve found with Tirz, potentially more so w Sema, is to just simply listen to your body. We do SO MUCH out of habit… why snack? It’s snack time, that’s why.
It’s so hard to push through.

In my experience not listening to the "stop" signal is the cause of most GLP sides. Do not eat past your appetite is the advice I offer to newbies,

Sema especially, is a brutal teacher in this regard. But learn you will....

 

[BeardedGuy]

In my experience not listening to the "stop" signal is the cause of most GLP sides. Do not eat past your appetite is the advice I offer to newbies,

Would agree. To be fair, most of us have never had a “stop” signal to notice. It’s a new phenomenon for us.
I’m trying to get my “signal” back. May be immunogenicity, may be “ate through from habit”… who knows. I’m trying to stack a bit of Sema with the Tirz to break through.

 

[Ghoul]

Would agree. To be fair, most of us have never had a “stop” signal to notice. It’s a new phenomenon for us.
I’m trying to get my “signal” back. May be immunogenicity, may be “ate through from habit”… who knows. I’m trying to stack a bit of Sema with the Tirz to break through.

That signal gets very weak, even just eating at structured meal times subtly undermines it over a lifetime.

 

[AlexDavis43]

View attachment 319244

https://www.ajgponline.org/article/%20S1064-7481(23)00394-9/fulltext

Excess body fat houses inflammatory macrophages that secrete all kinds of cytokines. Some of which involved in mental wellness, other diseases, etc.

Reducing that body fat, even before statistically significant reductions in total body weight, can help with many conditions.

*Enter the anti-GLP1 knuckle dragger hate comments. But it works with other methods that induce an energy deficit. (talking about gen pop not bodybuilders on a cut)

 

[aljowa]

The biggest challenge I’ve found with Tirz, potentially more so w Sema, is to just simply listen to your body. We do SO MUCH out of habit… why snack? It’s snack time, that’s why.
It’s so hard to push through.

The power of habit over our behavior on a subconscious level is really astounding once you pause and reflect on it. One of the most fascinating aspects of habits to me is the extent to which once a habit is formed, the mind seems to internalize this idea that the habit is a foundational pillar of your life that you were innately born with. It is as if all of the habits you engage in at a particular time in your life have always been there, and it is impossible to either cease them or form new ones. The mind seems to form a buffer around habits. It certainly takes a significant amount of mental fortitude to overcome this, but if/when you do, it then retrospectively seems like it wasn't that big of a deal. You think, like, "Why did it take me so long to get rid of that habit? Why the hell was I mindlessly doing that for so long?"

All habits aren't necessarily negative, either. Many of people's typical daily habits are quite positive/useful. For instance, I wake up and the first thing I do is brush my teeth and shower; I don't pause and consciously ask myself, "But why am I doing this?" Habits are like so many other things in life, neither inherently good or bad; it just depends on context. Just another example of how our mind is constantly attempting to simplify things in order to navigate existence more easily. On a very ironic level, the evolution of consciousness in the human mind is perhaps the most impressive and perplexing thing in the known universe, and yet the mind really seems to not want to think or exert cognitive energy, which is the defining feature of it. It's like having a superpower, but your mind does everything it can to discourage you from using it.

 

[BeardedGuy]

The power of habit over our behavior on a subconscious level is really astounding once you pause and reflect on it. One of the most fascinating aspects of habits to me is the extent to which once a habit is formed, the mind seems to internalize this idea that the habit is a foundational pillar of your life that you were innately born with. It is as if all of the habits you engage in at a particular time in your life have always been there, and it is impossible to either cease them or form new ones. The mind seems to form a buffer around habits. It certainly takes a significant amount of mental fortitude to overcome this, but if/when you do, it then retrospectively seems like it wasn't that big of a deal. You think, like, "Why did it take me so long to get rid of that habit? Why the hell was I mindlessly doing that for so long?"

All habits aren't necessarily negative, either. Many of people's typical daily habits are quite positive/useful. For instance, I wake up and the first thing I do is brush my teeth and shower; I don't pause and consciously ask myself, "But why am I doing this?" Habits are like so many other things in life, neither inherently good or bad; it just depends on context. Just another example of how our mind is constantly attempting to simplify things in order to navigate existence more easily. On a very ironic level, the evolution of consciousness in the human mind is perhaps the most impressive and perplexing thing in the known universe, and yet the mind really seems to not want to think or exert cognitive energy, which is the defining feature of it. It's like having a superpower, but your mind does everything it can to discourage you from using it.

Great points! I have no proof but I would think it’s two things: I did this yesterday and I survived; I should do that again.
“Thinking” is expensive, calorically and time-wise. It’s quite a luxury, really.
So, the body needs a good reason to dedicate resources to anything beyond the survival/spread seed thoughts.

 

[Country Club Hero]

Fucking steroid abuser thinks we're not drug addicts. smh

Nothing says natural "strength" like injecting artificial hormones to assuage psychological issues, body dysmorphia and insecurity.

It's most likely the same age GLP "addicts" who'll be waving goodbye as your LVH or stroked out corpse is lowered into the ground.

Ghoul, a tad off topic but something I’ve wondered about. Do you vigorously shake your reconstituted vial of Tirzepatide before drawing?

Or do you swirl it like with GH or other fragile peptides? And I’m talking about UGL Tirz that comes in a lypholized puck and needs reconstitution.

Also, fascinating topic. There’s a host of benefits from the glp drug class. It is crazy effective at allowing the user to reach goals with some minor discipline implementations. Just tons of benefits to these drugs overall. I’m so hoping the potential negative side effects don’t prove to be too bad. Almost too good to be true so that’s really my main concern. I guess we will see over time.

But yeah, I’ve been wondering if I should shake the piss outta my Tirz vial before drawing or not lol

 

[29trt]

Fucking steroid abuser thinks we're not drug addicts. smh

Nothing says natural "strength" like injecting artificial hormones to assuage psychological issues, body dysmorphia and insecurity.

It's most likely the same age GLP "addicts" who'll be waving goodbye as your LVH or stroked out corpse is lowered into the ground.

Where did you find your balls ? Were they in the accutane box or at the end of a sema vial?

Let's not talk about who is going to die sooner ..as your fat bastard genetics is going to get you no matter how much glp's you are on .

 

[aljowa]

Great points! I have no proof but I would think it’s two things: I did this yesterday and I survived; I should do that again.
“Thinking” is expensive, calorically and time-wise. It’s quite a luxury, really.
So, the body needs a good reason to dedicate resources to anything beyond the survival/spread seed thoughts.

That is certainly a plausible theory, and the most common one that the science seems to have settled on, for the time being. From a reductionist perspective, survival and reproduction seem to be the fundamental goals motivating virtually all animal actions on a psychological level; and if one accepts the legitimacy of the theories of evolution and natural selection, it really couldn't be any other way. I'm not sure where exactly I stand on the essentialism debate, but if all biological life does indeed share an essential feature, survival/reproduction would likely be it. It's not a very elegant way to view human life, lol, but that doesn't have any bearing on the truth of the matter. Kind of reminds me of that scene from the first Matrix film where Agent Smith tells Neo that when the machines classified the human species, they concluded that they fit appropriately in the category of a virus, because they observed that humans did not assimilate and coexist with their environment, they just reproduce and consume the resources around them with disregard.

Still doesn't explain the evolution of consciousness, though. Consciousness doesn't seem to be necessary for survival or reproduction. You can argue that in many ways it can prove to be quite detrimental to both. As you aptly phrased it, "thinking" is indeed quite expensive, so the fact that this capacity continued to develop in the human mind to such an excessive degree, well past the point of ensuring basic survival, is truly mysterious.


But I digress. Carry on with the relevant discussion of the unfolding GLP-1 revolution. I feel like my post epitomizes that meme, "Sir, this is a Wendy's." Haha.

 

[IronMetal_2]

In my experience not listening to the "stop" signal is the cause of most GLP sides. Do not eat past your appetite is the advice I offer to newbies,

Sema especially, is a brutal teacher in this regard. But learn you will....

So true. Tirz is a bit more forgiving. With Sema, I had one incident where I pushed beyond my appetite and the following night was a disaster Lol

 

[explodingHeart]

Something that's been casually observed for years, GLP class drugs soon to be a major component in treating addictions of all kinds.

“Wegovy rewired my brain. I have no desire for cigarettes and minimal desire for alcohol.”

How a Fortune 50 VP controlled his "20 pack-year" and a 5- to 6-drink a night habits.

recursiveadaptation.com

Hi Ghoul. I used deep search on perplexity and let it compile/summarize a lot of user experiences on GLPs addiction//mood/ADHD. Want me to dump it?

 

[LawrenceofUSA]

Would agree. To be fair, most of us have never had a “stop” signal to notice. It’s a new phenomenon for us.
I’m trying to get my “signal” back. May be immunogenicity, may be “ate through from habit”… who knows. I’m trying to stack a bit of Sema with the Tirz to break through.

Are you opposed to reta? Waiting for fda approval?

 

[BeardedGuy]

Are you opposed to reta? Waiting for fda approval?

Not opposed but Tirz is doing everything except hunger suppression and Reta has less suppression than Tirz.
Now, however, I’m learning about “receptor burnout” and that Sema+Tirz is not a great idea. So I’ll probably skip that plan. Maybe Cagri to help w appetite.

 

[Ghoul]

Not opposed but Tirz is doing everything except hunger suppression and Reta has less suppression than Tirz.
Now, however, I’m learning about “receptor burnout” and that Sema+Tirz is not a great idea. So I’ll probably skip that plan. Maybe Cagri to help w appetite.

I agree it's best not to fuck around with multiple GLPs, but receptor burnout is bullshit. Sounds like what some are using to explain a loss of effectiveness.