"Wegovy Rewired My Brain"

[Ghoul]

Something that's been casually observed for years, GLP class drugs soon to be a major component in treating addictions of all kinds.

“Wegovy rewired my brain. I have no desire for cigarettes and minimal desire for alcohol.”

How a Fortune 50 VP controlled his "20 pack-year" and a 5- to 6-drink a night habits.

recursiveadaptation.com

 

[explodingHeart]

Something that's been casually observed for years, GLP class drugs soon to be a major component in treating addictions of all kinds.

“Wegovy rewired my brain. I have no desire for cigarettes and minimal desire for alcohol.”

How a Fortune 50 VP controlled his "20 pack-year" and a 5- to 6-drink a night habits.

recursiveadaptation.com

So it's clear that using peptides that have been sitting for a while is dangerous and will accrue aggregates?

Ex: I used 3 month old MT2 and I had very bad reaction, while a fresh vial gives me hardly any reaction.

 

[joemidlife]

There's definitely something real about how these meds affect the brain. I quit alcohol cold turkey after three weeks on Mounjaro, but my digestion tanked hard after that.

When I looked deeper, the Ozempic lawsuit summary showed thousands of cases where people had similar nerve-related issues

 

[Middus]

There's definitely something real about how these meds affect the brain. I quit alcohol cold turkey after three weeks on Mounjaro, but my digestion tanked hard after that.

When I looked deeper, the Ozempic lawsuit summary showed thousands of cases where people had similar nerve-related issues

at least 85% of the things listed in the Lawsuit are non starters..
And then there's the case that anyone with went with UGL or Compounding pharmacies are already excluded.

 

[Ghoul]

at least 85% of the things listed in the Lawsuit are non starters..
And then there's the case that anyone with went with UGL or Compounding pharmacies are already excluded.

Yeah it's going nowhere. Truly serious issues resulting in injury are very few and far between, and most of those involved gastroparisis or eye nerve problems, only in those with diabetes where preexisting nerve damage likely existed. Both of those issues happen at high rates in those populations without GLPs. GLP drugs were just the final straw.

 

[BigDadd7]

So it's clear that using peptides that have been sitting for a while is dangerous and will accrue aggregates?

Ex: I used 3 month old MT2 and I had very bad reaction, while a fresh vial gives me hardly any reaction.

You used something that had been reconstituted for 3 months?

 

[Ghoul]

You used something that had been reconstituted for 3 months?

It is possible under the right conditions for some peptides to be stable, reconstituted, for a couple of years. Zepbound and Wegovy pens (Tirz and Sema). They don't even use BAC. Just sterile water, and PH adjusters. That's it, similar long shelf lives for pharma rHGH pens, insulin, Repatha etc.

But of course besides being manufactured, stored, and shipped in perfect conditions, the solution and container it's in are absolutely free of contaminants, biological and otherwise. Unlike the crap we get made by a 3rd class chemist's assistant with a Whatsapp handle and a filthy basement on his day off from the Wuhan Bat Disease research lab.

Was just reading a report analyzing 200 samples of UGL rHGH. Nothing surprising here.

 

[nail3r]

The day I started Sema, was the day I never touched my vape again.

I had previously been trying to get off, I had 3 failed attempts and I thought about it all the time. So I went into sema knowing that it may help me quit. It was so easy. What a relief.

 

[SlamSumTest]

which of the 3 do you think shine the brightest for overall health benefits (sema, tirz, Reta)?

 

[malfeasance]

who are convinced metabolic regulation isn't a thing, but merely a lack of willpower (which of course they possess and fatties don't)

Just like I (and, well, most) do not really have the internal drive to perform consistently at HIIT, and most just use it as an excuse to cut their cardio short because they are lazy.

Yeah, I mean, cocaine would probably help me hit the high intensity part of it, but that does not make it untrue that I simply lack the internal drive to do high intensity consistently to be true HIIT.

I mean, I like peanut butter, ice cream, and beer, too. I actually lusted after those things during competition prep. But I had a goal.

This is merely the latest delusion among a string of them, "it is not a lack of willpower." Before the "obesity drug" fad came along it was not this "willpower" delusional claim. The deluded fatties were instead busy telling me how little they actually ate. They had "tried everything" and they just were not blessed with a fast metabolism, that they got fat eating almost nothing. I would stare in disbelief, like, what are you talking about, I fucking know you and just watched you wash down a 3000 calorie meal with another 1000 or so in alcohol, a regular nightly routine. But, hey, guess what? The "obesity drug" works for them, too.

 

[SlamSumTest]

Just like I (and, well, most) do not really have the internal drive to perform consistently at HIIT, and most just use it as an excuse to cut their cardio short because they are lazy.

Yeah, I mean, cocaine would probably help me hit the high intensity part of it, but that does not make it untrue that I simply lack the internal drive to do high intensity consistently to be true HIIT.

I mean, I like peanut butter, ice cream, and beer, too. I actually lusted after those things during competition prep. But I had a goal.

I mean, that is the latest delusion, "it is not a lack of willpower." I mean, before the "obesity drug" fad came along it was not this "willpower" delusional claim. The deluded fatties were instead busy telling me how little they actually ate. They had "tried everything" and they just were not blessed with a fast metabolism, that they got fat eating almost nothing. I would stare in disbelief, like, what are you talking about, I fucking know you and just watched you wash down a 3000 calorie meal with another 1000 or so in alcohol, a regular nightly routine. But, hey, guess what? The "obesity drug" works for them, too.

It is interesting really. I’ve noticed how many people around me are “food obsessed,” like, every activity revolves around food where to me it is something that simply keeps me alive but won’t mind a nice meal or snack obviously. I care more about the fact that a dinner/lunch is a way to bring friends around, then you have people who are super picky/fussy and care so much about that burger or pizza joint.

When my friends want to go out to eat, to me the food is the secondary activity, to others it is an obsession.

You also have the folks who treat diet and food as religion with extreme black or white thinking (carnivore, keto, won’t touch anothing with sugar, Paul Saladino, Santa Cruz, blah blah).

I always found it odd, but maybe I’m the odd one? lol. I’m guessing a blend of autism/adhd especially with people in the diet religion crowd.

 

[malfeasance]

. I'm technically obese, however, the nurse practitioner said I was "vain" when she saw me?! lol The funny thing is, they have no problem giving me amphetamines but not the drugs that will help my entire body with less side effects.

Vain!

What was your response to that bitch?

 

[Ghoul]

which of the 3 do you think shine the brightest for overall health benefits (sema, tirz, Reta)?

Long term use they all offer similar longevity / health span benefits, indirectly over time by improving insulin sensitivity and reducing inflammation, and directly via GLP-1 receptor activation in many types of tissue, ie blood vessel endothelium, nerves, heart muscle, etc, but areas where each has a particular strength:

Sema - Neurological / Psychological benefits (anti-consumption / anti-addiction). Smaller molecule crosses blood brain barrier much more efficiently than the other two.

Tirz - Best glucose control / insulin sensitivity. Most balanced benefits overall, long term use tolerable, possible mild reactive hypoglycemia at high doses. (annoying but not dangerous), no known health harm risk.

Reta - Best for rapid liver fat reduction (NAFLD), long term use tolerable, no reactive hypoglycemia, but increased risk of possible cardiac remodeling / heart fibrosis and issues triggered by elevated heart rate.

 

[IronMetal_223]

Long term use they all offer similar longevity / health span benefits, indirectly over time by improving insulin sensitivity and reducing inflammation, and directly via GLP-1 receptor activation in many types of tissue, ie blood vessel endothelium, nerves, heart muscle, etc, but areas where each has a particular strength:

Sema - Neurological / Psychological benefits (anti-consumption / anti-addiction). Smaller molecule crosses blood brain barrier much more efficiently than the other two.

Tirz - Best glucose control / insulin sensitivity. Most balanced benefits overall, long term use tolerable, possible mild reactive hypoglycemia at high doses. (annoying but not dangerous), no known health harm risk.

Reta - Best for rapid liver fat reduction (NAFLD), long term use tolerable, no reactive hypoglycemia, but increased risk of possible cardiac remodeling / heart fibrosis and issues triggered by elevated heart rate.

Definitely agree with @Ghoul here. Glucose control was astonishing even on a fairly low dosage (3.75 mg) of tirzepatide per week. While these drugs shouldn't usually cause hypoglycemia, I frequently went hypo on it. fasting glucose was 65 mg/dL.

I am on Ozempic right now and while I gained some weight back, mentally I feel a lot better. It seems to help my OCD tendencies.

 

[Ghoul]

Definitely agree with @Ghoul here. Glucose control was astonishing even on a fairly low dosage (3.75 mg) of tirzepatide per week. While these drugs shouldn't usually cause hypoglycemia, I frequently went hypo on it. fasting glucose was 65 mg/dL.

I am on Ozempic right now and while I gained some weight back, mentally I feel a lot better. It seems to help my OCD tendencies.

Yeah, all the trials using GLP as an anti addiction treatment seem to be focusing on Sema as the most effective for that purpose, along with most of the anecdotal “came for the weight loss but my addiction to xxxxx disappeared along with the fat” anecdotes are overwhelmingly from Sema users.

 

[TheCup]

"GLP-1 modulates dopamine levels and glutamatergic neurotransmission, which results in observed behavioral changes."

Can GLP-1 Be a Target for Reward System Related Disorders? A Qualitative Synthesis and Systematic Review Analysis of Studies on Palatable Food, Drugs of Abuse, and Alcohol - PMC

The role of glucagon-like peptide 1 (GLP-1) in insulin-dependent signaling is well-known; GLP-1 enhances glucose-dependent insulin secretion and lowers blood glucose in diabetes. GLP-1 receptors (GLP-1R) are also widely expressed in the brain, and ...

pmc.ncbi.nlm.nih.gov

 

[SlamSumTest]

Yeah, all the trials using GLP as an anti addiction treatment seem to be focusing on Sema as the most effective for that purpose, along with most of the anecdotal “came for the weight loss but my addiction to xxxxx disappeared along with the fat” anecdotes are overwhelmingly from Sema users.

I’m on retatrutide and threw my vape out. That mental craving isn’t there as much and in the past when I tried to quit, I’d resort to snacking. But even now I view food as fuel and not to curb boredom. My caffeine habit is also down to 1 cup a day instead of 3.

This stuff really is amazing. I started this to get from my natural set point of 15% to 10% without the excessive food noise but notice a ton of benefits — I also seem to have more physical & mental energy despite dropping a lot of body fat.

It looks like I’m reaping a lot of the reward of the anti addiction properties, but this is Reta which to my knowledge doesn’t target GLP1 as much. I think I am going to try semaglutide next and stay on it indefinitely. I suspect I’m already very insulin sensitive as I’ve been 14-15% most of my life and eat a 60-70% carb diet, so not sure if tirz would be a benefit. My issues have always revolved around an addictive personality.