Why do i feel nothing from injections but feel transdermals

[Tyler81]

Here's a question.

I have been doing somewhat of a combined protocol of injections with gel.

The thing is, when I do an injection, anywhere from 50mg to 100mg, it just feels like im shooting water and I feel no benefits from it. No libido benefits. No mood benefits (infact 2-3 days after injection I fall into a bad depression which only lifts about a week after the shot)

So I do an injection, feel depressed for 3-5 days after doing it, and I continue the gel and I feel better after a week. But unlike the gel, I dont FEEL the injection at all.

When I apply the gel, I feel the rise and fall of my testosterone levels during the day.

I can FEEL it.

Why dont I feel any benefits from injections??????

Does it take time for injections to "kick in" as people say?

Im freaking glad I didnt ask my endo to switch to injections because i dont feel anything from them and I just feel moody when I do an injection. It basically sucks.

Whereas when I apply the gel in the morning, I feel it peaking around 5hours and I feel it dropping down after 8 hours. I can actually feel it.

Can someone explain this?

The gel feels much smoother and level and i dont have depression issues on it.

 

[Tyler81]

To add to this:

I am going to stop doing injections all together because i literally DREAD doing them.

Here's how it goes:
1. I do an injection
2. I feel depressed as fuck for 5 days
3. I continue the gel and the depression lifts after a week

I do another injection hoping for a different result but same thing happens.

Injections make me depressed as fuck!!!!!

And i dont think its estrogen because I have been doing aromasin to manage E2.

 

[dyna5]

that is interesting Tyler. i am doing injections and wonder if thats why im some friggin depressed. remember, T stimulated your central nervous system.mi suspect injections give a higher peak value the first few days after the injection and that in itself can cause it. whereas gel are much more stable from day to day.
did you do a comparison as to how high your dht goes on both?

 

[Tyler81]

that is interesting Tyler. i am doing injections and wonder if thats why im some friggin depressed. remember, T stimulated your central nervous system.mi suspect injections give a higher peak value the first few days after the injection and that in itself can cause it. whereas gel are much more stable from day to day.

Yeah. I really think it is the "peak level" that makes me depressed versus other theories such as estrogen which people put forward. When the gel was absorbing better for me, I would feel depressed on higher doses 7.5 or 10 g of the gels. But Iw would feel very good at 5g.

One theory I have is that very high TT (which injections cause due to the spike) might impact other systems in the body such as adrenal glands and thyroid to function less effectively.

It's just a theory and I cant know for sure.

All I know is that everytime I do a damn injection no matter whether it's 10mg, 25mg, 50mg, or 100mg, i feel depressed as fuck as the injection peaks and for a few days after and then the depression slowly lifts but it repeats the minute I do another injection.

At this point I am basically scared to do any more injections because I dread the depression that follows them.

 

[Tyler81]

DHT could be a factor and it could be why I "feel" the gels more than injections.

 

[chemman]

I don't have any ideas, but I do find this topic to be very interesting. I'm having one hell of a time with my depression right now. Idk if injections are making it harder to beat or not. I also have a variety of other issues that are certainly contributing.

 

[Tyler81]

I don't have any ideas, but I do find this topic to be very interesting. I'm having one hell of a time with my depression right now. Idk if injections are making it harder to beat or not. I also have a variety of other issues that are certainly contributing.

Yeah im not really sure.

All i know, anytime I do an injection I get horrible depression. It lasts about 3-5 days. It is worst when the injection is peaking about 3 days in. It lifts in about a week.

I dont have any such issues with gels.

I was almost going to ask my doctor to switch me to injections (because they are plan more convinent) but I am literally scared of the depression I feel after each injection.

Even the combined protocol I was considering doesnt make sense because I dread doing an injection even once a month.

 

[chemman]

Yeah im not really sure.

All i know, anytime I do an injection I get horrible depression. It lasts about 3-5 days. It is worst when the injection is peaking about 3 days in. It lifts in about a week.

I dont have any such issues with gels.

I was almost going to ask my doctor to switch me to injections (because they are plan more convinent) but I am literally scared of the depression I feel after each injection.

Even the combined protocol I was considering doesnt make sense because I dread doing an injection even once a month.

Have you ever asked your doctor about this? Does he have any ideas?

 

[Tyler81]

Have you ever asked your doctor about this? Does he have any ideas?

When I decided to commit to TRT i had already tried several delivery methods - patches, injections, clomid, and testim. Out of all those testim felt the smoothest to me and that's why i decided on it. My doctor wanted to prescribe me injections but I told him: "I dont feel as good on them. I prefer the gels." but i didnt really expand on that.

I believe he thinks im scared of injections or the peaks and troughs are what I am referring to.

Its not the peaks and troughs because I dont feel good at any point on injections. Guys who complain about the peaks and troughs at least feel good until the next shot is coming up where they dip a bit and feel bad. I feel plain bad from the moment I do an injection until i stop doing them! LOL

I could ask him but the issue is, I have a mood disorder too (bipolar 2) so he will probably think its related to that. It could be who knows - maybe it makes it worse.

All i know, as much as i *want* to switch to injections for lifestyle reasons it doesnt seem like I can realistically do it until i figure out why they make me depressed.

 

[chemman]

When I decided to commit to TRT i had already tried several delivery methods - patches, injections, clomid, and testim. Out of all those testim felt the smoothest to me and that's why i decided on it. My doctor wanted to prescribe me injections but I told him: "I dont feel as good on them. I prefer the gels." but i didnt really expand on that.

I believe he thinks im scared of injections or the peaks and troughs are what I am referring to.

Its not the peaks and troughs because I dont feel good at any point on injections. Guys who complain about the peaks and troughs at least feel good until the next shot is coming up where they dip a bit and feel bad. I feel plain bad from the moment I do an injection until i stop doing them! LOL

I could ask him but the issue is, I have a mood disorder too (bipolar 2) so he will probably think its related to that. It could be who knows - maybe it makes it worse.

All i know, as much as i *want* to switch to injections for lifestyle reasons it doesnt seem like I can realistically do it until i figure out why they make me depressed.

Yea man it could be a lot of things going on. I'm going to stop reading into this too much, lol. My gut feeling is that it is not the issue for me.

Injections are much better from a lifestyle perspective. I'm already on a decent list of meds, so being able to shoot on sunday and then shoot on wednesday at the same time as my humira shot really streamlines things. Applying the gel every day would suck. And I live in a hot and humid climate, so this summer would have been a total disaster with being covered in sweat all day long.

 

[Tyler81]

Yea man it could be a lot of things going on. I'm going to stop reading into this too much, lol. My gut feeling is that it is not the issue for me.

Injections are much better from a lifestyle perspective. I'm already on a decent list of meds, so being able to shoot on sunday and then shoot on wednesday at the same time as my humira shot really streamlines things. Applying the gel every day would suck. And I live in a hot and humid climate, so this summer would have been a total disaster with being covered in sweat all day long.

Yeah I know what you mean, believe me. The gels are a pain in the ass and if I could switch I would. This combined protocol I am trying was basically a "trial run" before I was going to formally ask my doctor to switch me to injections.

The funny thing is, he has NO problems switching me to injections and he wanted me to start me to them in the first place. I am doing this combined protocol because I wanted to make sure i want to switch since my transdermal gel is expensive and it;'s 90% covered under insurance.

Unfortunately, ive done maybe.... 4 injections eow and everytime the same shit happens.

Im basically going to abandon them for now.

As for your situation yeah i wouldnt overthink it.... your issue might be different.

That said, if you are at the end of your rope ie you have tried EVERYTHING then at least you can think: "Well, Tyler gets depressed on injections and feels good on gels, its a long shot but maybe that MIGHT work"

As shitty and annoying as it is applying gels, i would do this for the rest of my life rather than feel depressed as fuck like i feel after I do an injection. Truth.

 

[Tyler81]

Also keep in mind there are new and innovative delivery systems. Alot of guys on this forum has really positive things to say about "Axiron" which is like an underarm deoderant type application.

Even BBC is considering switching SOLELY to Axiron. So it must be good.

When it becomes available for me, I am going to switch to that too.

 

[chemman]

Yeah I know what you mean, believe me. The gels are a pain in the ass and if I could switch I would. This combined protocol I am trying was basically a "trial run" before I was going to formally ask my doctor to switch me to injections.

The funny thing is, he has NO problems switching me to injections and he wanted me to start me to them in the first place. I am doing this combined protocol because I wanted to make sure i want to switch since my transdermal gel is expensive and it;'s 90% covered under insurance.

Unfortunately, ive done maybe.... 4 injections eow and everytime the same shit happens.

Im basically going to abandon them for now.

As for your situation yeah i wouldnt overthink it.... your issue might be different.

That said, if you are at the end of your rope ie you have tried EVERYTHING then at least you can think: "Well, Tyler gets depressed on injections and feels good on gels, its a long shot but maybe that MIGHT work"

As shitty and annoying as it is applying gels, i would do this for the rest of my life rather than feel depressed as fuck like i feel after I do an injection. Truth.

So you inject every 14 days?

I'm considering going back to EOD injections. More needle sticks, but I don't recall having this degree of depression on that protocol. But I've definitely got some other shit going on in my life that is depressing no doubt about it. So it is hard to say what is what. So damn frustrating.

 

[foreveryoung]

So you inject every 14 days?

I'm considering going back to EOD injections. More needle sticks, but I don't recall having this degree of depression on that protocol. But I've definitely got some other shit going on in my life that is depressing no doubt about it. So it is hard to say what is what. So damn frustrating.

over the years I've done everyday, EOD, E3D, four day, five day, weekly,etc and if I had to pick the one best out of all of them I think E3D would be it for me

 

[chemman]

over the years I've done everyday, EOD, E3D, four day, five day, weekly,etc and if I had to pick the one best out of all of them I think E3D would be it for me

Interesting. That works out to roughly 2x/week

 

[Tyler81]

So you inject every 14 days?

I'm considering going back to EOD injections. More needle sticks, but I don't recall having this degree of depression on that protocol. But I've definitely got some other shit going on in my life that is depressing no doubt about it. So it is hard to say what is what. So damn frustrating.

Yeah something like that.

I've done maybe 4-5 injections total over the span of two months. Most have been 50(ish) but i've also done 100 and as low as 10-20mg.

100 makes me very depressed. But even 10-20 makes me depressed.

I really wish I could figure it out because I do want to switch to injections.

For now I will either stay on the transdermals with possibly a MONTHLY injection.

Or just drop the injections all together.

 

[Tyler81]

The only reason I am even doing injections is because im at the max dose of transdermal and I feel like it's not absorbing properly based on my strength in the gym, libido, and overall well-being. Yes, the bloodtest is showing 550 or so which is fine but 550 at 10g is very low!!!!! I used to routinely test 550 with 5g gel!!!!!!!!!!!!

The scary part is, that 550 was 800 when I first switched to 10g.

So definetly the absorption is getting worse and I am worried about it.

Damn injections make me depressed as fuck tho.

 

[keriheat]

@ Tyler, Have you ever been on injections and not used Testim or gels?

I'm just wondering if using both is causing a problem, even to a small degree.

 

[Tyler81]

@ Tyler, Have you ever been on injections and not used Testim or gels?

I'm just wondering if using both is causing a problem, even to a small degree.

Yeah after using the patch, injections were the second form of TRT i tried. I was really optimistic about it and I was doing 100mg per week. I experienced the same type of debilitating depression that I experience now after each injection. Eventually I got so fed up that I quit TRT altogether because I couldnt deal with the depression from shots anymore!!! I stayed off TRT for 8 months trying to get my natural libido back but it never came back. So then I went onto Testim and i've been doing well on it until recently as it seems it is not absorbing as well anymore.

I forgot about the depression associated with shots but now I remember.

 

[Tyler81]

I did 100mg injection on Sunday night.

As expected, i feel depressed as fuck right now on Tuesday night. The shot hasnt even peaked yet so i am dreading tomorrow because i usually feel shitty for at least 5 days after I do an injection.

This is also NOT an E2 issue because this time I took aromasin and its made no difference whatsoever in how I feel.

I am thinking this has to do with "peak levels" .... I cannot apply 10g gel in one shot, I have to break it up in 5g and 5g twice daily. Similarily, i get bad depression with shots ESPECIALLY AS THE SHOT IS PEAKING IN MY SYSTEM!!!!!!!!!

This could put stress on adrenals and therefore I get depressed. Not really sure.

I have even tried to do 10mg shot and even that peaks too high for me.

Either way I am done with injections because i cannot deal with this depression.

Back to ONLY GELS.