MESO-Rx
Anabolic Steroids
Why do i feel nothing from injections but feel transdermals
- Thread starter Tyler81
- Start date
foreveryoung
New Member
have you ever actually done a protocol of injections for a while without interrupting it? like, when I inject every 3 days, what I was feeling the first week or two is not the way it eventually ends up once giving it a chance to even out and stay on the protocol for many weeks, I think it still is evening out months in to a protocol....... ai's even add more confusion to the situation in trying to figure out what is going on in what you are feeling and why at any given time
and then if you add brain chemistry into the mix, these are things that one wants to nudge slowly in the right direction I think
and then if you add brain chemistry into the mix, these are things that one wants to nudge slowly in the right direction I think
m_ob
New Member
DHT, in my honest opinion, has to be one of the main factors. I felt more of an overall vigor on gels, where as with the injections that is lacking. I think that vigor has a direct correlation to my sex drive which is increased by the DHT.
Possibly yeah.
Hunches:
1. Injections negatively impact my neurotransmitters causing depression
2. Injections cause too high peak testosterone levels putting stress on my system which might affect things such as adrenals maybe cortisol ....
Whatever it is, whenever i do an injection i get depression.
There is no way in hell i could inject every three days. The depression would cause me to jump off a bridge. When I inject, I get depression while the shot peaks and then even a few days after and then it slowly goes away. The moment I do another shot, I get brutal depression again.
If I did shots every three days I would have non stop depression.
Yeah definetly.
DHT is a more powerful hormone than testosterone. It is responsible for things such as libido, voice deepening, and other "male" characteristics.
Fuck man.
I just popped a Wellbutrin 150mg XL .... i have some left over from when I was taking it about a year ago. My depression after taking this most recent 100mg shot is so fucking bleak that I need something for the next few days while it lifts.
The nice thing about Wellbutrin, there is a dopamine kick when you first start taking it but it only lasts 2-3 days. Then it's most norepinepherine.
Will take this for few days and wait this out. I should feel better by the weekend.
Screw injections. I am going back to transdermals only.
I just popped a Wellbutrin 150mg XL .... i have some left over from when I was taking it about a year ago. My depression after taking this most recent 100mg shot is so fucking bleak that I need something for the next few days while it lifts.
The nice thing about Wellbutrin, there is a dopamine kick when you first start taking it but it only lasts 2-3 days. Then it's most norepinepherine.
Will take this for few days and wait this out. I should feel better by the weekend.
Screw injections. I am going back to transdermals only.
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That happens to me too when i inject cypionate into the muscle.I have been on hrt for six years,and when i began with 200mg a week injections i felt great ,but starting last year even a low dose of 100mg a week would get me depressed.I figured out that it has something to do with my low shbg levels(around 11 ).So in the last year i have been injecting 50mg to 60mg cypionate sub-q every other day and this protocal work great for me no depression,just feeling good,great libido.Now the only testosterone i can inject intermuscular is prop at 30mg three times a week with no problems,but i like cypionate sub-q because it is just more convenient.
Hmm interesting.
You know its funny because people always talk about SHBG and mine is pretty low too.
I also used to do GREAT at 5g gel until recently.
So maybe the low SHBG causes alot of free testosterone from a lower dose of testosterone and too much causes TOO MUCH free testosterone and causes problems.
I never thought of that.... it could be part of the explanation.
YEAH its probably something along those lines,and it might have something to do with a slow thyroid.In any case a small amount of test sub-q works really well.I have experimented with lower amounts IM injections (60mg) and did not like it.I only do well with sub-q cypionate shots or 30mg test prop shots in the muscle.
Yeah ive considered thyroid issue and ive done some recent labs to see if my thyroid has gotten worse since being on TRT. It will be interesting to see the result.
Unfortunately ive been doing subq and even doses under 60mg cause depression.
Im feeling decent after taking that Wellbutrin yesterday. That stuff is like an instant relief when you first start taking it but then there is a 4-6 week adjustment period where it stops working and then it starts working again.
The first few days however are awesome
I never have used injectables but have used androgel for almost 7 years so I cannot compare and contrast. I do know that gels do use the skin as a testosterone reservoir that slowly enters the blood stream.
Perhaps your depression is because you test really spikes high after a shot. I have no experience so I can't address that problem.
What I do know from many others and from personal experience is that transdermals can increase your libido tremendously. This is likely due to increased DHT?? androgel is the best libido booster that I am aware of.
I must admit that androgel hasn't totally cured my ED. If I keep my testosterone in the 600+ range and watch E2 I am pretty good for veing almost 63. I still need generic viagra or levitra to get a rock hard erection.
Gels simply don't work for all. I think the same is true for shots.
I would try one or the other for a given period of time and monitor how you feel. Experiment with dose and frequency of shots and applications.
Good luck to you!
Perhaps your depression is because you test really spikes high after a shot. I have no experience so I can't address that problem.
What I do know from many others and from personal experience is that transdermals can increase your libido tremendously. This is likely due to increased DHT?? androgel is the best libido booster that I am aware of.
I must admit that androgel hasn't totally cured my ED. If I keep my testosterone in the 600+ range and watch E2 I am pretty good for veing almost 63. I still need generic viagra or levitra to get a rock hard erection.
Gels simply don't work for all. I think the same is true for shots.
I would try one or the other for a given period of time and monitor how you feel. Experiment with dose and frequency of shots and applications.
Good luck to you!
Tyler, I hate to say this. One of my pet peeves is someone saying "It's all in your head"
You said this depression happens with 10mg 50mg 100mg. What do you think would happen if you injected with a placebo? I not say'n you dont get depression, I'm just curious as to the cause.
Also, I dont remember about your E2 levels. I thought you were injecting IM. If you are injecting SubQ, It might elevate your E2, hence depression. I know in another thread LW was speaking too elevated E2 with SubQ injections for some men.
I know nothing. I'm just trying to raise possibilities.
You said this depression happens with 10mg 50mg 100mg. What do you think would happen if you injected with a placebo? I not say'n you dont get depression, I'm just curious as to the cause.
Also, I dont remember about your E2 levels. I thought you were injecting IM. If you are injecting SubQ, It might elevate your E2, hence depression. I know in another thread LW was speaking too elevated E2 with SubQ injections for some men.
I know nothing. I'm just trying to raise possibilities.
Marky Mark
New Member
What injections were you on? Nebido, Sust 250, Enanthate?
Maybe you could try switching to a different injection.
Maybe you could try switching to a different injection.
Tyler, I hate to say this. One of my pet peeves is someone saying "It's all in your head"
You said this depression happens with 10mg 50mg 100mg. What do you think would happen if you injected with a placebo? I not say'n you dont get depression, I'm just curious as to the cause.
Also, I dont remember about your E2 levels. I thought you were injecting IM. If you are injecting SubQ, It might elevate your E2, hence depression. I know in another thread LW was speaking too elevated E2 with SubQ injections for some men.
I know nothing. I'm just trying to raise possibilities.
Hey no worries man. I am not gonna be offended by that suggestion. If it was the case that would be amazing. Unfortunately it is not because back in June I injected 10mg on a friday, and by monday i was noticeably depressed.
Now keep in mind, I want to feel good on injections. So when I do an injection I get optimistic that i will feel better or at least not bad and then when the depression starts setting in within 24hours of the injection i get discouraged.
I only change one variable at a time when I make changes to my protocol so when I do an injection there is NO OTHER VARIABLE CHANGING. So it definetly a cause/effect relationship. A direct correlation.
Its very frusterating to say the least. If I could figure it out it would make my life so much easier and better because then I could switch to once weekly injections.
But for now (until i figure it out) I have to continue the trandermals.
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Test E
I have considered Nebido actually. Because if "peaking" is the issue, maybe after Nebido peaks in my system i will feel better as it starts to drop down.............
But it's risky to try it because I know its a long acting ester that will be in my system for awhile.
Its encouraging that you have used Androgel for 7 years. I know some guys can stay on the transdermals for a long time with no issues.
I am having some absorption issues right now which is why I am experimenting with shots. I do all the stuff you do like shower, scrub my torso and apply to lowfat areas. But still having absorption issues.
Any ideas on how to maximize transdermal absorption ? i.e. get it into the skin's resevoir?
Here's an idea:
If the depression is being caused by the high peak TT (i feel worst as the shot is peaking) perhaps i could do one injection per month at say 400mg.
I would feel like shit for the first week, but after the injection peaks in my system, i would start to feel better as it starts to drop down and since the half life is 7-10 days I would be good for a month.
This is totally SPECULATION and i dont know if it would work like that.
All i know, whether i do 10mg, 50mg, 100mg, 150mg, i feel worse as the shot is PEAKING and then once it's peaked and few days after, i start to feel better.
If the depression is being caused by the high peak TT (i feel worst as the shot is peaking) perhaps i could do one injection per month at say 400mg.
I would feel like shit for the first week, but after the injection peaks in my system, i would start to feel better as it starts to drop down and since the half life is 7-10 days I would be good for a month.
This is totally SPECULATION and i dont know if it would work like that.
All i know, whether i do 10mg, 50mg, 100mg, 150mg, i feel worse as the shot is PEAKING and then once it's peaked and few days after, i start to feel better.
Pharmacokinetics and pharmacodynami... [Acta Endocrinol (Copenh). 1990] - PubMed - NCBI
Pharmacokinetics and pharmacodynamics of testosterone enanthate and dihydrotestosterone enanthate in non-human primates.
This study states that following an injection, androgen levels remain high for 3-5 days followed by a drop until they eventually get back to baseline.
This is consistent in how I feel bad for approx 3-5 days after an injection, and after 5 days when the levels start dropping down the depression i feel starts to lift.
This seems to be the exact opposite of most guys who feel good during the peak but feel bad closer to the end of the week.
Pharmacokinetics and pharmacodynamics of testosterone enanthate and dihydrotestosterone enanthate in non-human primates.
This study states that following an injection, androgen levels remain high for 3-5 days followed by a drop until they eventually get back to baseline.
This is consistent in how I feel bad for approx 3-5 days after an injection, and after 5 days when the levels start dropping down the depression i feel starts to lift.
This seems to be the exact opposite of most guys who feel good during the peak but feel bad closer to the end of the week.
