Why would masteron/primo lower libido?

[lebroseixoife-6939]

I've been doing TRT off and on for a few years now, and every time I take Masteron or Primo, it kills my libido. While the reported effects are supposed to raise libido, for me, it swells up my prostate, gives me a good feeling, and dries me out, but no libido increases. Whereas, if I take an AI, like Anastrozole, at .25mg once or twice a week, the old penis gets friendly and happy. I am in my early 40s, taking about 120mg of test cyp a week, two injections every 3.5/4 days. 6'1", 220 pounds. Depending on my feelings, I lift and run about 3-5 times weekly. I
My last test results (with some Masteron mixed in there, probably 10mg three times a week. I was taking p5p, but I stopped that since my prolactin was low. I sometimes take 3mg of boron.):
Test Total: 1444 ng/dl
Test Free: 358 pg/mL
SHBG: 16.3 nmol/L
prolactin: 4 ng/mL
Estradiol (non-ultrasensitive): 21 pg/mL

 

[Methyltst1993]

throw primobolan and drostanolone in the trash. That has nothing to do in TRT.
You have too low prolactin, estradiol and SHBG.

DHT derivatives mainly reduce SHBG and when it is low, sex libido goes down.

Take 120mg tst per week, nothing more. Divide the dose at least 3 times a week.
Prolactin, estradiol and SHBG will increase and libido will rise.

 

[lebroseixoife-6939]

throw primobolan and drostanolone in the trash. That has nothing to do in TRT.
You have too low prolactin, estradiol and SHBG.

DHT derivatives mainly reduce SHBG and when it is low, sex libido goes down.

Take 120mg tst per week, nothing more. Divide the dose at least 3 times a week.
Prolactin, estradiol and SHBG will increase and libido will rise.

That works. Thanks!

 

[bighunanballs]

throw primobolan and drostanolone in the trash. That has nothing to do in TRT.
You have too low prolactin, estradiol and SHBG.

DHT derivatives mainly reduce SHBG and when it is low, sex libido goes down.

Take 120mg tst per week, nothing more. Divide the dose at least 3 times a week.
Prolactin, estradiol and SHBG will increase and libido will rise.

agreed if youre not capable of dialing them in properly using constant blood work then dont fuck with the DHT's, its not TRT

 

[amazonas]

throw primobolan and drostanolone in the trash. That has nothing to do in TRT.
You have too low prolactin, estradiol and SHBG.

DHT derivatives mainly reduce SHBG and when it is low, sex libido goes down.

Take 120mg tst per week, nothing more. Divide the dose at least 3 times a week.
Prolactin, estradiol and SHBG will increase and libido will rise.

This is very true, i've tried both mast and primo on top of TRT, but i ALWAYS have better libido on Test only + AI. No matter what dosage i have tried. Primo destroyed my libido while i was on it for over a year and i had no idea the cause. It wasn't just "low e2" as other people say. Had several blood tests done showing optimal e2.

It simply crushed my SHBG and that's not good for libido.

Previously it was known that low SHBG = higher test = good. But that's not the case.

 

[UncleBuns]

I've been doing TRT off and on for a few years now, and every time I take Masteron or Primo, it kills my libido. While the reported effects are supposed to raise libido, for me, it swells up my prostate, gives me a good feeling, and dries me out, but no libido increases. Whereas, if I take an AI, like Anastrozole, at .25mg once or twice a week, the old penis gets friendly and happy. I am in my early 40s, taking about 120mg of test cyp a week, two injections every 3.5/4 days. 6'1", 220 pounds. Depending on my feelings, I lift and run about 3-5 times weekly. I
My last test results (with some Masteron mixed in there, probably 10mg three times a week. I was taking p5p, but I stopped that since my prolactin was low. I sometimes take 3mg of boron.):
Test Total: 1444 ng/dl
Test Free: 358 pg/mL
SHBG: 16.3 nmol/L
prolactin: 4 ng/mL
Estradiol (non-ultrasensitive): 21 pg/mL

30mg mast a week is a very small dose. Surprised it would have anything beyond a very minor effect. The answer to your problem is simple. If you take something and it makes you feel bad and don't take it. You're way over thinking this.

 

[Spaceman Spiff]

throw primobolan and drostanolone in the trash. That has nothing to do in TRT.
You have too low prolactin, estradiol and SHBG.

DHT derivatives mainly reduce SHBG and when it is low, sex libido goes down.

Take 120mg tst per week, nothing more. Divide the dose at least 3 times a week.
Prolactin, estradiol and SHBG will increase and libido will rise.

I agree it has nothing to do with trt.

Never heard of low shbg lowering libido other than from vigorous Steve

 

[y777]

Too much dopamine /noradrenaline in ur system makes it harder to desire something that raises dopamine.

Think “coke dick “

 

[FunkOdyssey]

i've tried both mast and primo on top of TRT, but i ALWAYS have better libido on Test only + AI. No matter what dosage i have tried. Primo destroyed my libido

Same here, adding primo and masteron to TRT only killed libido and caused depressed mood. Same with Proviron. In my personal experience, AI's are able to control E2 with less adverse effects than DHT derivatives, contrary to current trends in E2 management.

 

[EnhancedChimpTBK]

I don't understand your Masterson dosage at 10mg 3x a week. Did you mean 100mg 3x a week?

 

[lebroseixoife-6939]

I don't understand your Masterson dosage at 10mg 3x a week. Did you mean 100mg 3x a week?

That's not a typo. 10mg of mast prop three times a week. MWF. I have tried 1:1 ratios (so, 120mg a week) and almost nothing.

 

[HUGE McBIGLARGE]

Prolactin, estradiol and SHBG will increase and libido will rise.

I have no idea where people keep getting this idea from that prolactin helps sexual functioning. The studies we have show that in men, pharmacologically induced hypoprolactinemia causes improvements in sexual function.

 

[Methyltst1993]

DHT derivatives (Mesterolon, Primo) reduce the SHBG hormone and this is the result of low libido. Never use more than one DHT derivative in a cycle.

 

[HUGE McBIGLARGE]

What’s the mechanism behind SHBG improving libido?

 

[Spaceman Spiff]

What’s the mechanism behind SHBG improving libido?

Cause the word "sex" is in the acronym

Case closed

 

[FunkOdyssey]

Never heard of low shbg lowering libido other than from vigorous Steve

Ryan Root talks about this pretty often too:



View: https://youtube.com/shorts/AoLCt9hCV-o?si=ibQ3-1FmrzFDGHXY



View: https://youtu.be/lqs4abT2W6M?si=RJLnR93fIrd0fn_6

 

[HUGE McBIGLARGE]

Ryan Root talks about this pretty often too:



View: https://youtube.com/shorts/AoLCt9hCV-o?si=ibQ3-1FmrzFDGHXY



View: https://youtu.be/lqs4abT2W6M?si=RJLnR93fIrd0fn_6

Can’t find a source on it though. The closest thing I can find on SHBG and androgen sensitivity is this, which has nothing to do with what he said

Applicability of the SHBG androgen sensitivity test in the differential diagnosis of 46,XY gonadal dysgenesis, true hermaphroditism, and androgen insensitivity syndrome - PubMed

The sex hormone-binding globulin (SHBG) androgen sensitivity test has been used as a simple method to assess androgen receptor function in vivo. After a short term oral administration of the anabolic-androgenic steroid stanozolol the mean nadir serum concentration of SHBG is used as a measure of...

pubmed.ncbi.nlm.nih.gov

Here’s one explanation: because SHBG binds weakly to estradiol, a low SHBG could mean high free estradiol, or a skewed freeT/freeE2 ratio. Other than that I’ve got no idea. Not that I’m an expert of course.

 

[eryximachus]

Even if they don't know the mechanism, both Masteron and Primobolan were developed for breast cancer. AIs are just so far superior, the drugs stopped being manufactured. So there is that.

 

[UncleBuns]

Even if they don't know the mechanism, both Masteron and Primobolan were developed for breast cancer. AIs are just so far superior, the drugs stopped being manufactured. So there is that.

Mast was originally developed for breast cancer but everything else you've stated is wrong. I've never understood why bro scientists latch on to what a drug was originally developed for. AAS and many pharmaceuticals are developed with a certain use in mind, but then later it is found that it is much more useful for another purpose. There are so many examples of this in the pharmaceutical world. What's important is what the drug actually does, not what what the original developers were looking for.

Please, state your case why AI is "far superior". State your case why those drugs are bad because they aren't made by pharmaceutical companies anymore.

Pure nonsense. Try again.

 

[bighunanballs]

Mast was originally developed for breast cancer but everything else you've stated is wrong. I've never understood why bro scientists latch on to what a drug was originally developed for. AAS and many pharmaceuticals are developed with a certain use in mind, but then later it is found that it is much more useful for another purpose. There are so many examples of this in the pharmaceutical world. What's important is what the drug actually does, not what what the original developers were looking for.

Please, state your case why AI is "far superior". State your case why those drugs are bad because they aren't made by pharmaceutical companies anymore.

Pure nonsense. Try again.

Agreed, that was a pretty nonsensical statement.

An AI might be superior to masteron simply because masteron is not an AI lol. However if you need to run e2 higher to make use of your HGH maybe you want the estrogen beta receptor stimulation of masteron to keep gyno in check but reap other benefits to running e2 slightly elevated out of range.

Primo does have a metabolite that acts as an AI, how would running an AI be better than another anabolic that can act as an AI?