Wuhan Wansheng Biotechnology Co., Ltd. (USA, International)

These are fairly complicated drugs

One theory as to why they're so effective at once weekly dosing is that it causes downregulation of some receptors that take time to recover

A little hunger returning on day 5 or 6 (right before your next dose) might be part of how it works so effectively in clinical trials
Reta doesnt have as aggressive suppression as the other two buy its def there. On tirz I couldnt even think about fokd without getting nauseous. Reta im able to get food in thats needed but you get that full feeling early and aticks around. I dont want to lift and starve lol you never keep any gains. They way it works on gluclose is insane! Cant wait to see even at low dose how it does with the insulin sensitivity and added igf during a bulk
 
How long have you been taking it? I've been on a glp for 3 years. Have a feeling my dosing experience has been different than yours.
It will because you're not him amd hes not you. Everyome need to remember that when finding THEIR sweetspot
 
A little hunger returning on day 5 or 6 (right before your next dose) might be part of how it works so effectively in clinical trials
3x a week for the past 12 weeks. Down 22 lbs. I dunno. I'd rather not have the hunger rebound every week, so whatever magic is helping me avoid that I'll take it.
 

Why approved as once-weekly (not daily):​


Weekly dosing is chosen because superior long-term adherence/persistence (50–60% at 1 year vs. 20–35% for daily) outweighs the slightly flatter PK profile of daily dosing. Efficacy is essentially identical or slightly better with weekly at the same total exposure.


Why someone would still choose daily (or split doses):​


To dramatically reduce nausea/vomiting — daily micro-dosing gives an even flatter concentration curve and much lower Cmax, so peak-related GI side effects often disappear while keeping the same weekly exposure and full efficacy. Convenience is sacrificed for tolerability.
 
Even at 12mg Reta doesn't kill my appetite. Everyone responds differently and over time smaller doses become less and less effective.
Very true - some folks get the usual GLP appetite crushing form Reta, some get zero.

I just increased from 2 mg twice weekly to 2.5 mg twice weekly. 24 hours after the first dosage of 2.5 mg and my appetite is curbed quite a bit. That said I switched from Tirz to Reta specifically because even on a cut I could not eat enough on Tirz. I was able to get up to 3000-3200 cals daily for a few months on the 4 mg Reta but decided to bump it to keep things moving. I don't think I will go above 8 mg prior to taking a break from it.
 
Very true - some folks get the usual GLP appetite crushing form Reta, some get zero.

I just increased from 2 mg twice weekly to 2.5 mg twice weekly. 24 hours after the first dosage of 2.5 mg and my appetite is curbed quite a bit. That said I switched from Tirz to Reta specifically because even on a cut I could not eat enough on Tirz. I was able to get up to 3000-3200 cals daily for a few months on the 4 mg Reta but decided to bump it to keep things moving. I don't think I will go above 8 mg prior to taking a break from it.
lol it’s def hard to eat on TIrz which is great if you’re trying to cut and drop pounds but lean bulking not so much. I do find that THC helps with maintaining somewhat of an appetite.
Reta doesnt have as aggressive suppression as the other two buy its def there. On tirz I couldnt even think about fokd without getting nauseous. Reta im able to get food in thats needed but you get that full feeling early and aticks around. I dont want to lift and starve lol you never keep any gains. The way it works on gluclose is insane! Cant wait to see even at low dose how it does with the insulin sensitivity and added igf during a bulk
Rethinking my plan lol. I thought RETA would make it even harder to eat then TIRZ. If what you’re saying are the facts; well the I’m going to do the same thing during my bulk. Ill throw in the TIRZ during the last few weeks of my cut to quiet the hunger pains but the RETa I’ll take at low dose during my bulking cycle. Im excited

Gonna start with a little dbol for the first month. test, EQ, tren, mast, RETA through out the whole cycle and I’ll end with Winny and some
 
lol it’s def hard to eat on TIrz which is great if you’re trying to cut and drop pounds but lean bulking not so much. I do find that THC helps with maintaining somewhat of an appetite.
What I have not tried, and Idk if i will since I prefer Reta but if I do ever go back to tirz, is combining boldenone with tirz for the appetite bump.
 
lol it’s def hard to eat on TIrz which is great if you’re trying to cut and drop pounds but lean bulking not so much. I do find that THC helps with maintaining somewhat of an appetite.

Rethinking my plan lol. I thought RETA would make it even harder to eat then TIRZ. If what you’re saying are the facts; well the I’m going to do the same thing during my bulk. Ill throw in the TIRZ during the last few weeks of my cut to quiet the hunger pains but the RETa I’ll take at low dose during my bulking cycle. Im excited

Gonna start with a little dbol for the first month. test, EQ, tren, mast, RETA through out the whole cycle and I’ll end with Winny
Yeah its why a lot of lifters are turning to it along with the way it helps with insulin sensitivity and steady gluclose curves
 
What I have not tried, and Idk if i will since I prefer Reta but if I do ever go back to tirz, is combining boldenone with tirz for the appetite bump.
EQ works to. I’ve done that as well along with THC on my last cycle. 1st time adding any kind GLP-1. I’m leaner than I’ve ever been but def lost some muscle along the way. All good though. I will gain it right back when I bulk up.
 
These are fairly complicated drugs

One theory as to why they're so effective at once weekly dosing is that it causes downregulation of some receptors that take time to recover

A little hunger returning on day 5 or 6 (right before your next dose) might be part of how it works so effectively in clinical trials
Most likely it works in spite of, not because of, the low serum levels on day 5-6. And there is no evidence of down-regulation of receptors, given that people are still losing weight 1.5 years into the clinical trials at the same dose.
 
Most likely it works in spite of, not because of, the low serum levels on day 5-6. And there is no evidence of down-regulation of receptors, given that people are still losing weight 1.5 years into the clinical trials at the same dose.

Dan Drucker and Jim Johnson have commented on receptor downregulation being part of why once weekly dosing was so effective

I mean, you do you, if your protocol is working well for you, go for it
 
H36 kits from US and China warehouses are yellow tops. I bought some in August from US and China in October. What are the chances they are from the same batch? Anyone test H36 recently?
 
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