Wuhan Wansheng Biotechnology Co., Ltd. (USA, International)

Yes it’s a QC issue, don’t let them gaslight you.

“Oh we’ve been vacuum sealing vials for years for fun, it doesn’t actually mean anything, you know how much Chinese businesses enjoy spending money they don’t have to with useless extra work like this.”

Most of the cheaper vendors won’t do shit about it, but we need to keep calling it out.

Filter it to ensure sterility which of course is compromised, and to remove most of the aggregates that oxidative damage makes more likely to form, (you should be filtering regardless of vacuum).

Ensure the kit is refrigerated. I know most do anyway but some don’t, and without going too far down the rabbit hole, when peptides are damaged by oxidation, they can still function (attach to the receptor), but they become less stable to temperature degradation. So a peptide that might’ve been ok for a month at room temp (in dry form), let’s say losing 1%, may degrade 10% after being oxidized.

Here are 4 vials of different formulations of lyophiiized rHGH. The percentages at the top of the bars is the amount of oxygen left in the headspace (the empty area in the vial). Only the dark bars matter. You can see .75% oxygen makes the rHGH degrade nearly twice as fast at room temp as .45% oxygen.

View attachment 364579



Pharma doesn’’t use vacuum, it can fail because the continuous vacuum force on the stopper can suck in air, moisture, and bacteria if the seal isn’t perfect, movement in transport etc, causing degradation and loss of sterility, a major problem as far as they and the FDA are concerned.

Instead they vacuum and backfill with an inert gas like nitrogen. The funny thing is even the cheap lyophilization machines UGLs use can do this if someone hooks up a nitrogen canister. It would cost nearly nothing, and keep peptide quality up much longer, especially because unlike pharma, UGL peptides are exposed to uncontrolled temps in storage, an often very high heat in shipping container la (150°f+ in summer).

Nitrogen flush is standard for commercial manufacturers of peptides.

View attachment 364574

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The World Health Organization minimum standard for lyophilized rHGH includes nitrogen flush.

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Really appreciate this extensive context and validation of my concerns. I reiterated those concerns and a request for a reshipment to the rep, and even after he asked to see your specific response, he responded that I "missed the point" and suggested I invert the vial when injecting the BAC water. Obviously he's either misunderstanding or deliberately avoiding acknowledging the issue. In either case, I'm tired of arguing the point with this guy, so he's won, but for those considering an order, be aware that you should not count on a reshipment if you encounter the same issue.
 
Is it recommended to filter the oils if buying from these guys? I've also used the domestic sellers on this forum and never had to filter anything?
Id say yes for anything coming from china, we have no idea where/who's actually doing the brewing and with the strange colors and floaters aswell only seems right. Personally I dont buy oils anymore from them, only peptides. Canadian ugls i trust for oils.
 
I thought there were COA’s about the purity being close to 98% for reta 10mg. So the concern with reta 10mg is more about the vacuum seal and sterility?
 
I thought there were COA’s about the purity being close to 98% for reta 10mg. So the concern with reta 10mg is more about the vacuum seal and sterility?

One report doesn’t mean this lack of vacuum is a pattern. The point it shouldn’t be allowed to slide when it does happen. If anyone else comes forward that should give you pause. It would be helpful if anyone can confirm there’s hasn’t had this issue, so we’ll know if it’s most likely an isolated incident.
 
One report doesn’t mean this lack of vacuum is a pattern. The point it shouldn’t be allowed to slide when it does happen. If anyone else comes forward that should give you pause. It would be helpful if anyone can confirm there’s hasn’t had this issue, so we’ll know if it’s most likely an isolated incident.
Well I got some 10’s I can check out
 
Id say yes for anything coming from china, we have no idea where/who's actually doing the brewing and with the strange colors and floaters aswell only seems right. Personally I dont buy oils anymore from them, only peptides. Canadian ugls i trust for oils.
Ah that makes sense. I might look into the peptides but definitely don’t feel like having to filter oils so I’ll probably stay away from those lol
 
Ah that makes sense. I might look into the peptides but definitely don’t feel like having to filter oils so I’ll probably stay away from those lol
I’m not saying oils don’t need to be filtered but I believe peptides more so than oils are more likely needed to be filtered.
 
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Really appreciate this extensive context and validation of my concerns. I reiterated those concerns and a request for a reshipment to the rep, and even after he asked to see your specific response, he responded that I "missed the point" and suggested I invert the vial when injecting the BAC water. Obviously he's either misunderstanding or deliberately avoiding acknowledging the issue. In either case, I'm tired of arguing the point with this guy, so he's won, but for those considering an order, be aware that you should not count on a reshipment if you encounter the same issue.
Mind me asking which rep was that?
 
Hi

Does anyone know if the Acetic Acid Water that WWB sells is suitable for reconstituting the Alprostadil that he sells?

When I was about to order his Alprostadil and AA water together he mentioned that the AA water that they sell is specifically made to mix with AOD and he was unsure if it would mix with anything else other than that.

He’s unsure of what his costumers normally use to reconstitute Alprostadil, I would have assumed that it was the same AA water he sells but now I’m not certain myself either.

Thanks
 
Hi

Does anyone know if the Acetic Acid Water that WWB sells is suitable for reconstituting the Alprostadil that he sells?

When I was about to order his Alprostadil and AA water together he mentioned that the AA water that they sell is specifically made to mix with AOD and he was unsure if it would mix with anything else other than that.

He’s unsure of what his costumers normally use to reconstitute Alprostadil, I would have assumed that it was the same AA water he sells but now I’m not certain myself either.

Thanks
Doing a quick search, it looks like the name brand versions of this are reconstituted with bac water.


"Caverject Impulse (alprostadil) for injection contains sterile, freeze-dried alprostadil for reconstitution and sterile bacteriostatic water in a prefilled dual chamber glass cartridge. It is available in 10 mcg and 20 mcg strengths"
 
I thought there were COA’s about the purity being close to 98% for reta 10mg. So the concern with reta 10mg is more about the vacuum seal and sterility?

Got 3 kits of 10mg Reta, all of them are vacuumed so far, just got one vial that felt slightly „off“ and not fully vacuumed, but all fine so far. Shit is working great, I’m happy, wife is happy, friends are happy.
 
Order number 2 has arrived! Placed on 19th Nov, Tracking 22nd, Arrived 1st Dec. So 12 days from payment. All good no damage. I will check the vaccuum seals as I start using the stuff.

Couldn't resist getting some of the 100IU 10mL HGH vials! It will be interesting to see if the 10mL NAD+ and HGH bottles have good vacuum seals on them. Havent seen peptides in 10mL vials before and as far as I know they dont vacuum seal AAS, so will they have a machine to do 10mL vials?

I also placed another order on 28th with the black friday prices, waiting on tracking confirmation.
 
Doing a quick search, it looks like the name brand versions of this are reconstituted with bac water.


"Caverject Impulse (alprostadil) for injection contains sterile, freeze-dried alprostadil for reconstitution and sterile bacteriostatic water in a prefilled dual chamber glass cartridge. It is available in 10 mcg and 20 mcg strengths"
Agreed but a few PE forums advise AA water as does ChatGPT.

I appreciate u taking the time to search and trying to help out though :-)
 

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Agreed but a few PE forums advise AA water as does ChatGPT.

I appreciate u taking the time to search and trying to help out though :-)
You know what - that makes sense. The name brand ones are single dose injectors. So unless you plan on using your whole vial in one shot - chatgtp might be on to something...


Grok says this, btw:

Alprostadil for injection (the active ingredient in Caverject, Edex, Trimix/Quadmix/Bimix compoundscan be reconstituted with two different types of water, and the choice matters a lot for comfort, stability, and how long the vial stays usable.

### Bacteriostatic Water (BW or “Bac Water”)
- Contains 0.9–1% benzyl alcohol as a preservative
- What the FDA-approved brand-name products (Caverject, Caverject Impulse, Edex) all use
- Slightly less painful on injection because benzyl alcohol is a mild local anesthetic
- Officially approved for multi-dose use (the package insert says the reconstituted vial is good for 24 hours at room temperature, but many clinics and the manufacturer’s own stability data allow refrigerated storage for weeks)
- Downside: benzyl alcohol can, over weeks/months, slowly degrade prostaglandins (alprostadil is a prostaglandin E1). In practice this is rarely a very slow process when refrigerated, and most men finish a 5–20 µg vial long before significant potency loss occurs.

### Sterile Water with Acetic Acid 0.6% (“AA Water” or “Prostaglandin Reconstitution Solution”)
- Sold by many 503A/503B compounding pharmacies specifically for Trimix, Bimix, Quadmix
- Contains a tiny amount of acetic acid (vinegar) to drop the pH to ~4, which dramatically improves alprostadil stability
- No benzyl alcohol → no slow degradation of the prostaglandin
- Pharmacies that ship Trimix nationwide almost always use this because vials routinely last 3–6 months frozen and 30–90 days refrigerated with essentially zero potency loss
- Downside: the acetic acid makes the injection sting/burn noticeably more than bacteriostatic water for most men (some describe it as “hot” or “burning” for 30–60 seconds). A few guys don’t notice any difference, but the majority do.

### Why the difference in recommendations?

- Brand-name manufacturers (Pfizer, Schwarz Pharma/Endo) only tested and got FDA approval with bacteriostatic water, so that’s what they have to tell you to use.
- Compounding pharmacies and men who compound their own (or use “research” alprostadil) want maximum shelf life and rock-solid potency 3–6 months later, so they switched to the acetic-acid version years ago and have stability data showing it’s vastly superior for long-term storage.

### Practical advice most experienced users and urologists follow

- If you are using an official Caverject/Edex kit → just use the diluent they give you (it’s bacteriostatic water). You’ll finish the vial in a few weeks anyway.
- If you are using compounding-pharmacy Trimix/Quadmix/Bimix or raw alprostadil powder → most people use the acetic-acid water the pharmacy provides because the vial will last 3–6 months with no measurable loss of strength. Accept the extra sting or…
- Some guys who are very pain-sensitive ask the compounding pharmacy to reconstitute with bacteriostatic water instead (many pharmacies will do it on request). You trade a little shelf life for much less burn.

Bottom line
“Bac water” = less pain, perfectly fine shelf life for most people, required for FDA-approved products.
“AA water” = more sting, but near-perfect long-term stability, standard in the compounding world.

Choose based on how long you need the vial to last and how sensitive you are to injection-site burn.
 
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