Zero appetite

[Joseph Plunkett]

Id need to see you current blood work with the 100mcg dosage your on now, to get an idea on where your at, and if that dosage is even enough for you without that cycle.

Its not always as easy as increasing t4 , if your not a good converter, then it will just go to rt3 and not where you want it , making issues worse so to answer thats it be difficult.

As far as t3 , if labs and temperature and heart rate show and indicate that your lagging then there are a few supplements that work very well at rasing t3 naturally.

I know women that are 90lbs soak and wet and thee replacement is 100mcg and im guessing your much larger, so thats why im curious. Thyroid works on a negative feedback loop so if your under dosed taking t4 then your going to be more hypothyroid etc, untill you reach that doasge you need or untill t3 is added to correct the ratio.

2nd , why are you on 50mg a day of clomid? I can see a preventive doasge of 25mg a day or even 25mg 3x a week but your not getting any hpa recovery using clomid on that amount of gear fyi. If you were on trt then yes you could on 25mg of clomid. That alone could be effecting you.

Also you should add in some p5p for a bit of prolactin control prevention.

Check your temperature, morning afternoon and bedtime along with your heart rate prior to any activitys. This is beyond the best way to know how your metabolism is acting if done correctly.

Does p5p even work though?

If it does, I might some myself.

Although most supps are well….. a cash grab.

 

[Harley00]

Does p5p even work though?

If it does, I might some myself.

Although most supps are well….. a cash grab.

Yes p5p works, of coures its dosage dependent vs strength of the gear your on thats causeing prolactin issues, but p5p works for most , untill something stronger is needed.

I don't agree with supplements being cash grabs, supplements are great when used correctly, and thats if you know everything else that gets effected by the supplements your taking and use the supplements on a cycle bases for the purposes you need.

But...Test boosters i would agree are a cash grab, yeh they may lower shbg and add some free test , but for the general purpose of increasing test.. its a cash grab. For a splash of a boost for a pct protocol, sure might help there too but otherwise your wasting your money.

 

[AromasinSucks]

@TheIncredibleBulk it’s the clomid. Whenever I take any level dosage of it, my appetite nosedives. Remove it and watch your appetite come back.

 

[Gigantic]

@TheIncredibleBulk it’s the clomid. Whenever I take any level dosage of it, my appetite nosedives. Remove it and watch your appetite come back.

Mine came back, seems I adjusted to it anyway despite all compounds. Still on clomid.

 

[AromasinSucks]

Mine came back, seems I adjusted to it anyway despite all compounds. Still on clomid.

How long did it end up taking? Good to hear

 

[Gigantic]

How long did it end up taking? Good to hear

Like 3-4 weeks… it wasn’t great man. I basically stopped my bulk anyway since I’m having a dramatic improvement in my quality of life.

Basically, still on the cycle, but not actively trying to gain anything.

 

[TrenTrenTren]

Wait until a couple of weeks pass on that NPP... Jesus Christ.. I was insatiable

Me too. I got fat as hell. Never again with NPP for me.

 

[Megadick3000]

Like 3-4 weeks… it wasn’t great man. I basically stopped my bulk anyway since I’m having a dramatic improvement in my quality of life.

Basically, still on the cycle, but not actively trying to gain anything.

Care to elaborate on the QOL? Is this related to your spinal issues and, perhaps, the NPP giving relief in that department?

Im not positive on the exact specifics of your spinal problems but you may want to consider looking into Pentosan Polysulphate Sodium, do some googling around about it, i read a guy claiming he pins his wife with it and its a major QOL improvement for her joint issues. Just throwing that out there, since it seems QOL is becoming your primary focus so you might want to leave no stone unturned in pursuit of improvements.

 

[Megadick3000]

PPS

The pathobiology of osteoarthritis and the rationale for the use of pentosan polysulfate for its treatment​

P Ghosh 1
Affiliations expand

• PMID: 10073500
• DOI: 10.1016/s0049-0172(99)80021-3

Abstract​

Objectives: Structure-modifying osteoarthritis (OA) drugs (SMOADs) may be defined as agents that reverse, retard, or stabilize the underlying pathology of OA, thereby providing symptomatic relief in the long-term. The objective of this review was to evaluate the literature on sodium pentosan polysulfate (NaPPS) and calcium pentosan polysulfate (CaPPS), with respect to the pathobiology of OA to ascertain whether these agents should be classified as SMOADs.
Methods: Published studies on NaPPS and CaPPS were selected on the basis of their relevance to the known pathobiology of OA, which also was reviewed.
Results: Both NaPPS and CaPPS exhibit a wide range of pharmacological activities. Of significance was the ability of these agents to support chondrocyte anabolic activities and attenuate catabolic events responsible for loss of components of the cartilage extracellular matrix in OA joints. Although some of the anti-catabolic activities may be mediated through direct enzyme inhibition, NaPPS and CaPPS also have been shown to enter chondrocytes and bind to promoter proteins and alter gene expression of matrix metalloproteinases and possibly other mediators. In rat models of arthritis, NaPPS and CaPPS reduced joint swelling and inflammatory mediator levels in pouch fluids. Moreover, synoviocyte biosynthesis of high-molecular-weight hyaluronan, which is diminished in OA, was normalized when these cells were incubated with NaPPS and CaPPS or after intraarticular injection of NaPPS into arthritic joints. In rabbit, canine, and ovine models of OA, NaPPS and CaPPS preserved cartilage integrity, proteoglycan synthesis, and reduced matrix metalloproteinase activity. NaPPS and CaPPS stimulated the release of tissue plasminogen activator (t-PA), superoxide dismutase, and lipases from vascular endothelium while concomitantly decreasing plasma levels of the endogenous plasminogen activator inhibitor PAI-1. The net thrombolytic and lipolytic effects exhibited by NaPPS and CaPPS may serve to improve blood flow through subchondral capillaries of OA joints and improve bone cell nutrition. In geriatric OA dogs, NaPPS and CaPPS reduced symptoms, as well as normalized their thrombolytic status, threshold for platelet activation, and plasma triglyceride levels. These hematologic parameters were shown to be abnormal in OA animals before drug treatment. Similar outcomes were observed in OA patients when CaPPS or NaPPS were given orally or parenterally in both open and double-blind trials.
Conclusions: The data presented in this review support the contention that NaPPS and CaPPS should be classified as SMOADs. However, additional long-term clinical studies employing methods of assessing joint structural changes will be needed to confirm this view.

 

[Gigantic]

Care to elaborate on the QOL? Is this related to your spinal issues and, perhaps, the NPP giving relief in that department?

Im not positive on the exact specifics of your spinal problems but you may want to consider looking into Pentosan Polysulphate Sodium, do some googling around about it, i read a guy claiming he pins his wife with it and its a major QOL improvement for her joint issues. Just throwing that out there, since it seems QOL is becoming your primary focus so you might want to leave no stone unturned in pursuit of improvements.

Yeah, it’s mostly my back. The pain is gone, and I can actually stand up and walk correctly. I can go around and do anything.

It’s been a problem since I was around 17, and I figured I’d need a lot more time to repair the back… apparently I don’t. Between Test, NPP, HGH, BPC-157 and TB-500, I got some amazing healing. My shoulder and wrist injury are also gone. They had been giving me trouble for years.

I am down to 150 NPP/week, still no pain. Could NPP be masking it? Maybe. We’ll see. For now, I’m really just running around right now enjoying life without pain and fucking my women.

For sure, I’ll check out PPS if it gets worse.

 

[cdoubleu]

Thatsy awesome the healing ended up coming around for yah.

 

[MFAAS]

Wake up, sandwich. Mayo, meats, cheese, homemade bread. Glass of milk with fiber to prevent roid constipation.

Lunch… same. Right now there’s no variation, but everything else looks disgusting.

Dinner: whatever the wife cooks. Usually very very healthy and has plenty of meat. Wait 3-4 hours after eating, then take HGH.


Previously I’d be desperate to eat 4x as much… I’m afraid to eat carbs while taking HGH so I’ve completely cut bullshit out of my diet to avoid diabetes… maybe this is it? It’s at least a contributing factor.

If you take HGH at night then your insulin response is pretty normal by the next day. Carbs are your friend! I had a homemade sourdough bagel with 5 eggs and zucchini and broccoli this morning.

 

[Para_33]

I recently started my bulk cycle. 4 days in and I have zero appetite. Why? I used to be able to eat everything.

Current cycle:

500mg/week of Test C
450mg/week of NPP
50mg/day Clomid (prescription)
5.77iu/day of HGH
100mg/day of T4 (prescription)

I’m eating two meals a day, if that. At one point I was lifting fasted, and just had no energy.

I am just not hungry at all… I didn’t even touch my dinner. Anyone have insight into why based on my above compound list?

Did you start the HGH recently ?

I’m betting your T4 is too low, the increased conversion from HGH may have caused you to deplete your t4 reserve.

Solutions could be go in for thyroid panel, Free T4, Free T3, and TSH just for extra data.

Or you could just try increasing to 150T4 or something and try that for a few days. If that improves it quickly, I think that was your issue

 

[Gigantic]

Did you start the HGH recently ?

I’m betting your T4 is too low, the increased conversion from HGH may have caused you to deplete your t4 reserve.

Solutions could be go in for thyroid panel, Free T4, Free T3, and TSH just for extra data.

Or you could just try increasing to 150T4 or something and try that for a few days. If that improves it quickly, I think that was your issue

T4 is pretty good now, I think. I take Synthroid with it.

 

[Rido]

Did you start the HGH recently ?

I’m betting your T4 is too low, the increased conversion from HGH may have caused you to deplete your t4 reserve.

Solutions could be go in for thyroid panel, Free T4, Free T3, and TSH just for extra data.

Or you could just try increasing to 150T4 or something and try that for a few days. If that improves it quickly, I think that was your issue

your body typically adapts to it. it just increases conversion. I know we have talked about t4 being broscience and not typically applicable to HGH usage.


I have done some blood work and atleast for someone who has a baseline functioning thyroid. It wasnt necessary.

 

[Gigantic]

your body typically adapts to it. it just increases conversion. I know we have talked about t4 being broscience and not typically applicable to HGH usage.


I have done some blood work and atleast for someone who has a baseline functioning thyroid. It wasnt necessary.

Yeah, unfortunately my thyroid isn't working correctly, so I need it regardless.