Inquiring Mind
Member
God willing. Thank you brother!
MESO-Rx
Anabolic Steroids
chronic lymphocytic leukemia
- Thread starter Inquiring Mind
- Start date
God willing. Thank you brother!
Inquiring Mind
Member
Can’t tell you how much everything you said means to me. Thank you for the link.
@Inquiring Mind I also am very sorry to learn about your diagnosis. It's good CLL tends to progress slowly in most folks but suspect it's also frustrating not to push forward now with treatment that might resolve the problem. Your blood counts and genetic analysis results can produce a reasonable prediction of how aggressive the disease will be and your doc was likely quoting those statistics to you.
Those statistics were drawn from looking at how the disease behaved in a large number of people. How well those folks took care of themselves, their other medical problems, their attitude and the amount of support they had are only some of the factors the model can't really take into account. You have a good attitude and a strong support system. I know you'll take very good care of yourself. I suspect you'll do much better than the model predicts.
My best wishes to you sir.
Those statistics were drawn from looking at how the disease behaved in a large number of people. How well those folks took care of themselves, their other medical problems, their attitude and the amount of support they had are only some of the factors the model can't really take into account. You have a good attitude and a strong support system. I know you'll take very good care of yourself. I suspect you'll do much better than the model predicts.
My best wishes to you sir.
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Inquiring Mind
Member
You hit it right in th nose...like we have to just wait till something or nothing happens and live life wondering anything it can hit with full force.
Besides reading up on diets and lifestyle changes, me and my wife are also talking about getting our wills drawn and reviewing our life insurances..things we avoided taking about cause it was uncomfortable. I have to take advantage while I have some time! I can’t leave them unsecured.
My wife have been up late researching, she is a bright young lady. Smarter than I am. LOL.
Anyway, she was telling the same thing about statistics and how they can be severely misleading.
Onething I will mention, and I hope everyone reading pays close attention. I only learned about my disease because I privately draw floods so often, and because I frequently go to my doctors. If I fart wrong I’m gonna see a doctor. LOL.
Anyway, for a few years now I’ve noticed my white count was always higher and so were my lymphocytes (also a form of wbc). I had bright it up to my primary, but he was always dismissive. I even rly dropped his ass and got a new primary. When I showed him my reports he immediately sent me to a
hematologist-oncologist, were upon I get the fatal news.
Takeaway from this is that while we are on anabolics, we should no doubt be pulling bloods, but more importantly, we should strive to learn how to read and interpret them, and most importantly, be able to discuss ANY AND ALL concerns with our doctors.
Msl3862, I’m going to do the best I can for my family! I have to. I owe it to my wife and my two little kids.
Thank you for taking the time to speak to me.
Be well and God bless.
IM
Statins, common drugs used for the treatment of high cholesterol, may have found another potential application. In addition to their effects on the cholesterol pathway, statins can also inhibit the activity of BCL2 and related proteins, which interfere with apoptosis in many cancer types. In light of this connection, Lee et al. examined the effects of statins on several types of leukemias and lymphomas. The authors determined that statins prime cancer cells for apoptosis and work in synergy with drugs such as venetoclax, an inhibitor of BCL2. In addition to demonstrating this synergy in mouse models, the authors provided data from three studies of patients with chronic lymphocytic leukemia, showing that patients receiving statins had better clinical responses to venetoclax.
Lee JS, Roberts A, Juarez D, et al. Statins enhance efficacy of venetoclax in blood cancers. Science Translational Medicine 2018;10. Statins enhance efficacy of venetoclax in blood cancers
Statins have shown promise as anticancer agents in experimental and epidemiologic research. However, any benefit that they provide is likely context-dependent, for example, applicable only to certain cancers or in combination with specific anticancer drugs. We report that inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) using statins enhances the proapoptotic activity of the B cell lymphoma-2 (BCL2) inhibitor venetoclax (ABT-199) in primary leukemia and lymphoma cells but not in normal human peripheral blood mononuclear cells. By blocking mevalonate production, HMGCR inhibition suppressed protein geranylgeranylation, resulting in up-regulation of proapoptotic protein p53 up-regulated modulator of apoptosis (PUMA). In support of these findings, dynamic BH3 profiling confirmed that statins primed cells for apoptosis. Furthermore, in retrospective analyses of three clinical studies of chronic lymphocytic leukemia, background statin use was associated with enhanced response to venetoclax, as demonstrated by more frequent complete responses. Together, this work provides mechanistic justification and clinical evidence to warrant prospective clinical investigation of this combination in hematologic malignancies.
Lee JS, Roberts A, Juarez D, et al. Statins enhance efficacy of venetoclax in blood cancers. Science Translational Medicine 2018;10. Statins enhance efficacy of venetoclax in blood cancers
Statins have shown promise as anticancer agents in experimental and epidemiologic research. However, any benefit that they provide is likely context-dependent, for example, applicable only to certain cancers or in combination with specific anticancer drugs. We report that inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) using statins enhances the proapoptotic activity of the B cell lymphoma-2 (BCL2) inhibitor venetoclax (ABT-199) in primary leukemia and lymphoma cells but not in normal human peripheral blood mononuclear cells. By blocking mevalonate production, HMGCR inhibition suppressed protein geranylgeranylation, resulting in up-regulation of proapoptotic protein p53 up-regulated modulator of apoptosis (PUMA). In support of these findings, dynamic BH3 profiling confirmed that statins primed cells for apoptosis. Furthermore, in retrospective analyses of three clinical studies of chronic lymphocytic leukemia, background statin use was associated with enhanced response to venetoclax, as demonstrated by more frequent complete responses. Together, this work provides mechanistic justification and clinical evidence to warrant prospective clinical investigation of this combination in hematologic malignancies.
Inquiring Mind
Member
I just want to thank everyone for taking the time to come in and express positive messages and offer prayers.
This place became my 2nd home so to say. I know most can relate, so when I say I appreciate everyone, I’m speaking from the bottom of my heart. Thank you all and God bless!!
This place became my 2nd home so to say. I know most can relate, so when I say I appreciate everyone, I’m speaking from the bottom of my heart. Thank you all and God bless!!
I realize this is an old post. Hope OP is doing well. @Inquiring Mind make sure you know all about ibrutinib.
Inquiring Mind
Member
Thank you for taking the time to go through my thread and for your suggestion. I will look further into this. Currently I have been in remission. Whatever happens will happen..I took the time to get my life in order to the best of my ability. The rest is at the gym and in God’s hands. LOL.
And no doubt, all you guys here at Meso...like a second family.
It'
It's a miracle drug for CLL if you ever need it! Good luck!
Genuinely I wish you the best of luck with all this. And you are without a doubt one strong fella for keeping all this together, so respect for that man!
I seen in your earlier posts that you mentioned growth hormone. I would stay far clear of it until you are 100% sure that you wont get the crap end of the odds.
From my understanding its pretty well documented that growth hormone will cause exponential growth of cancer.
If someone more knowledgeable disagrees please correct me. Just speaking from what I have read in research.
Inquiring Mind
Member
Thank you my brother...I have asked this directly to my oncologist and his advise to stay clear is consistent with yours..so no GH for me. And thank you very, very much for your time and interest..
I missed your original posts but just came across this thread. I was diagnosed a few years ago with large granular lymphocytes leukaemia. I had to have my spleen removed due to low rbc’s but otherwise I have been healthy. I can tell you for sure it had nothing to do with AAS or any hormones for that matter because I had never used them prior to my diagnosis. About a year and half ago I went on TRT and feel way better and my blood markers have been perfectly steady and in some respects are better since starting. I also cleared this with my hematologist before starting, she was perfectly fine with it. I don’t know how your condition compares to mine but don’t beat yourself up about it. It’s doubtful anything you did contributed to it, and if so it’s virtually impossible to know what the cause is anyway. Good luck!
Inquiring Mind
Member
It’s encouraging to hear about others doing well from disease..I’m glad you are doing well, and thank you for the words or encouragement..I’m in remission..so all is well so far.
