HGH Anything you wish you knew before you got started?

[Benf15harp]

That’s why we’re all on hgh. All the 18 year olds are just finally figuring out our secrets!

Little bastards. Can’t we micro-penises have one GD thing to ourselves lol

 

[Bronze6Actual]

This is the most comprehensive guide to HGH… Type2 and Havens have nothing on this

H

Thread 'Practical Application of HGH'

Sep 25, 2024

Hi all

I've been working tirelessly on an e-book the last few months, summarized on all my formal and informal education, practical experience coaching athletes of various demographics and backgrounds, and tireless effort on developing an understanding of the practical application of growth hormone. Theres and enormous volume of info out there about growth hormone, but nothing that was to the point on "how do I actually use this stuff?!" so I decided to fill that gap.

Please, give me your feedback after reading and let me know what you think.

• Helix
• growth hormone hgh hgh beginner human growth hormone
• Replies: 34
• Forum: Human Growth Hormone and Peptides

• 
• 
• 

 

[egruberman]

I heard someone say the other day that 6mg was the dose at which maximal hyperplasia occurs and that beyond that is diminishing returns, thus the use of that dose for HIV patients.

I quick review of the literature yielded nothing about hyperplasia. The 6mg dose was settled upon because it was the maximum tolerable dose on average for patients that needed an acute increase in lean body mass.

It seems there's a linear, dose dependent response with regard to reduction in body fat and an increase in lean muscle tissue anywhere from 1-6mg.

 

[Sam312xx]

Why the hate on qsc?

I'm looking to buy their HGH and I have seen nothing so far that would make me doubt their authenticity.

 

[egruberman]

Why the hate on qsc?

Where did you see hate for QSC? HGH is one of their most well-regarded products and if you catch a deal, it's a cheap as there is.

 

[Sam312xx]

Where did you see hate for QSC? HGH is one of their most well-regarded products and if you catch a deal, it's a cheap as there is.

I'm poor because I choose pharmaceutical somatropin, covered by my insurance, over your shitty chinese HGH? You buy unbranded HGH from QSC, who's poor?

That's just one example but it's all over the forum. I just want to understand what specifically is the complaint about generic hgh? What does it lack compared to pharma?

 

[egruberman]

That's just one example but it's all over the forum. I just want to understand what specifically is the complaint about generic hgh? What does it lack compared to pharma?

Yeah, I have that fucktwit on ignore, so I have no idea.

There is no scientific basis for a distinction between what QSC produces and pharma HGH. I use the word "pharma" loosely as there are different production methods. Serostim is the only HGH made in the USA. People claim anecdotally that it hits differently. I believe them, but there is no measurable difference that I can find.

All commonly available HGH is 22kDa 191aa peptide. There are various excipients used, but usually it's some kind of sugar-based filler and a buffering agent. Serostim is derived from mammalian cells. Most generic pharma is derived from E. Coli, I believe that most UGL HGH is also derived from E. Coli. The purification process is different, the former being more complex. Regardless, the end result yields similar purity and dimer across Serostim, generic pharma, and UGL HGH.

There may be some differences in bioavailability, but the literature shows a similar rise in IGF-1 and similar growth outcomes between Serostim and generic pharma HGH. UGL HGH yields a similar rise in IGF-1.

There may be other mechanisms that we are unaware of, but the primary driver of anabolism from HGH is a result of the fact that it stimulates secretion of IGF-1. Many people have reported a similar dose dependent response in serum IGF-1 between Serostim, generic pharma, and UGL HGH.

In light of all this, we can use Serostim, which is hard to source and an order of magnitude more costly than UGL HGH, we could use generic "pharma" HGH from a Turkish vendor that is likely counterfeit, or we could use QSC HGH at a fraction of the cost and achieve the same levels of IGF-1 secretion or use the money we saved to get more HGH and increase the dose.

The rational choice seems obvious to me, which explains why I'm sitting here typing this after just having injected 12iu of QSC HGH. People may chime in with feelz or they may chime in with some personal anecdotal experience, but I haven't seen one single shred of evidence of a measurable difference between the various options.

To be clear, I believe those that say "it hits differently", I'm open to the possibility that there may be a difference in bioavailability or some mechanism of action I don't understand, but it's not represented in the literature nor has anyone shown me a difference in blood values.

 

[Sam312xx]

Yeah, I have that fucktwit on ignore, so I have no idea.

There is no scientific basis for a distinction between what QSC produces and pharma HGH. I use the word "pharma" loosely as there are different production methods. Serostim is the only HGH made in the USA. People claim anecdotally that it hits differently. I believe them, but there is no measurable difference that I can find.

All commonly available HGH is 22kDa 191aa peptide. There are various excipients used, but usually it's some kind of sugar-based filler and a buffering agent. Serostim is derived from mammalian cells. Most generic pharma is derived from E. Coli, I believe that most UGL HGH is also derived from E. Coli. The purification process is different, the former being more complex. Regardless, the end result yields similar purity and dimer across Serostim, generic pharma, and UGL HGH.

There may be some differences in bioavailability, but the literature shows a similar rise in IGF-1 and similar growth outcomes between Serostim and generic pharma HGH. UGL HGH yields a similar rise in IGF-1.

There may be other mechanisms that we are unaware of, but the primary driver of anabolism from HGH is a result of the fact that it stimulates secretion of IGF-1. Many people have reported a similar dose dependent response in serum IGF-1 between Serostim, generic pharma, and UGL HGH.

In light of all this, we can use Serostim, which is hard to source and an order of magnitude more costly than UGL HGH, we could use generic "pharma" HGH from a Turkish vendor that is likely counterfeit, or we could use QSC HGH at a fraction of the cost and achieve the same levels of IGF-1 secretion or use the money we saved to get more HGH and increase the dose.

The rational choice seems obvious to me, which explains why I'm sitting here typing this after just having injected 12iu of QSC HGH. People may chime in with feelz or they may chime in with some personal anecdotal experience, but I haven't seen one single shred of evidence of a measurable difference between the various options.

To be clear, I believe those that say "it hits differently", I'm open to the possibility that there may be a difference in bioavailability or some mechanism of action I don't understand, but it's not represented in the literature nor has anyone shown me a difference in blood values.

I was thinking that maybe although the end product is generally the same (22kDa 191 amino acids), the purification process might vary between manufacturers, and this could lead to subtle differences in impurities or degradation products. Some people may be more sensitive to these differences, even if the core HGH molecule remains the same across brands. These subtle impurities could affect bioavailability or provoke an immune response in a small number of users, leading to different “feelings” after injection.

Just a wild guess, who knows. I want to try it myself but I'm a bit worried because I'm in Canada and the Canadian warehouse is sold out. I've never ordered from China and since it's a large number of vials I worry that if it gets caught in customs they might press charges against me.

 

[readalot]

Yeah, I have that fucktwit on ignore, so I have no idea.

There is no scientific basis for a distinction between what QSC produces and pharma HGH. I use the word "pharma" loosely as there are different production methods. Serostim is the only HGH made in the USA. People claim anecdotally that it hits differently. I believe them, but there is no measurable difference that I can find.

All commonly available HGH is 22kDa 191aa peptide. There are various excipients used, but usually it's some kind of sugar-based filler and a buffering agent. Serostim is derived from mammalian cells. Most generic pharma is derived from E. Coli, I believe that most UGL HGH is also derived from E. Coli. The purification process is different, the former being more complex. Regardless, the end result yields similar purity and dimer across Serostim, generic pharma, and UGL HGH.

There may be some differences in bioavailability, but the literature shows a similar rise in IGF-1 and similar growth outcomes between Serostim and generic pharma HGH. UGL HGH yields a similar rise in IGF-1.

There may be other mechanisms that we are unaware of, but the primary driver of anabolism from HGH is a result of the fact that it stimulates secretion of IGF-1. Many people have reported a similar dose dependent response in serum IGF-1 between Serostim, generic pharma, and UGL HGH.

In light of all this, we can use Serostim, which is hard to source and an order of magnitude more costly than UGL HGH, we could use generic "pharma" HGH from a Turkish vendor that is likely counterfeit, or we could use QSC HGH at a fraction of the cost and achieve the same levels of IGF-1 secretion or use the money we saved to get more HGH and increase the dose.

The rational choice seems obvious to me, which explains why I'm sitting here typing this after just having injected 12iu of QSC HGH. People may chime in with feelz or they may chime in with some personal anecdotal experience, but I haven't seen one single shred of evidence of a measurable difference between the various options.

To be clear, I believe those that say "it hits differently", I'm open to the possibility that there may be a difference in bioavailability or some mechanism of action I don't understand, but it's not represented in the literature nor has anyone shown me a difference in blood values.

Thank you for taking the portion of your life you used to type that up to type that up. Very useful information written in tight and accessible English.

 

[bighunanballs]

There are theories as to why serostim may have slightly different side effects profile than high quality generics. We've seen sero tested at Jano in the 98% and very low if none detected dimer. Also seen similar produced from QSC. All generics use mannitol in the lyophilization process. Serostim does not.... Mannitol acts a a diuretic.

There are also theories that the mammalian derived serostim molecules might be helically shaped differently than the ecoli derived generics. As far as I know, no one has used high power microscopy to check

 

[deadbeef]

Here's my anecdotal evidence to add to the pile: I've been alternating between QSC HGH and serostim. My IGF-1 is sky high on both, and I have no sides on either. Basically, I can't tell any difference between them. I'm only on 2 IU, though.

 

[Sam312xx]

If there are differences in the folding, they seem to be subtle enough that they do not cause significant differences in IGF-1 secretion or overall growth outcomes. Also, proteins produced in mammalian cells can undergo glycosylation or other modifications that bacteria like E. coli are incapable of performing which could alter stability or bioavaliability.

I find it fascinating that there is no published research that has used microscopy methods to compare the helical shapes of HGH from mammalian cells versus E. coli. This would cost somewhere between 200k to 1mil. All sorts of money is being thrown at the most ridiculous things, but research that could provide valuable insights into the structural differences between mammalian-derived HGH and E. coli-derived HGH is not of interest.

 

[eery]

There are theories as to why serostim may have slightly different side effects profile than high quality generics. We've seen sero tested at Jano in the 98% and very low if none detected dimer. Also seen similar produced from QSC. All generics use mannitol in the lyophilization process. Serostim does not.... Mannitol acts a a diuretic.

There are also theories that the mammalian derived serostim molecules might be helically shaped differently than the ecoli derived generics. As far as I know, no one has used high power microscopy to check

is that dosage of mannitol high enough to have an effect on dieuresis though? i wouldnt think so but i might be wrong. Its like <30mg mannitol in if i remember correctly

 

[AlexDavis43]

Mannitol acts a a diuretic.

The dose of mannitol as a diuretic is orders of magnitude higher than that used as a filler. Like 100s x more (ref) (many refs).

 

[bighunanballs]

The dose of mannitol as a diuretic is orders of magnitude higher than that used as a filler. Like 100s x more (ref) (many refs).

See what happens when folks (me) parrot stuff we hear off YouTube without doing research. Lol

 

[robert3]

This is the most comprehensive guide to HGH… Type2 and Havens have nothing on this

H

Thread 'Practical Application of HGH'

Sep 25, 2024

Hi all

I've been working tirelessly on an e-book the last few months, summarized on all my formal and informal education, practical experience coaching athletes of various demographics and backgrounds, and tireless effort on developing an understanding of the practical application of growth hormone. Theres and enormous volume of info out there about growth hormone, but nothing that was to the point on "how do I actually use this stuff?!" so I decided to fill that gap.

Please, give me your feedback after reading and let me know what you think.

• Helix
• growth hormone hgh hgh beginner human growth hormone
• Replies: 34
• Forum: Human Growth Hormone and Peptides

• 
• 
• 

i fell for this shit twice

 

[Bronze6Actual]

i fell for this shit twice

This is the best and most comprehensive material on GH

 

[Carlo84]

Maybe try the “Glow” Peptide protocol, it’s a mix of Ghk-Cu, Bpc 157x, TB500, I and many others I know have had great anti-aging results. Also, I’m less experienced in this one but if you’re over 40 then consider looking into NAD+.

I’ve seen that glow mix come in 10mg vials, how do you dose it?

 

[Carlo84]

BGL checks, metformin could be helpful. Also, check your TSH, T4:T3, as GH increases the conversion, therefore causing a hypothyroidism due to negative feedback.

Do you supplement with T4?

 

[SpicyMeatball]

BGL checks, metformin could be helpful. Also, check your TSH, T4:T3, as GH increases the conversion, therefore causing a hypothyroidism due to negative feedback.

My most recent labs showed:
- Free Testosterone (Direct) fell from 10.1 in September (right before starting HGH) to 6.3 (reference range 6.8-21.5) a few weeks ago.
- TSH/Free T4/Free T3 are all in-range.
- Insulin jumped from 11 to 19.8, which is in reference range but a significant jump.

I started on metformin about 3 weeks ago to help avoid insulin resistance (I'm hovering just below pre-diabetic A1C threshold, 5.6, and have family history of diabetes).

Any thoughts on what might be going on here? Taking 2.5iu daily in the morning, 3 hours before any food. Metformin 500mg after breakfast and again after dinner. IGF-1 is 325, up from a pre-GH baseline of 132.